Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Tom A, Gardiner"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxida
Externí odkaz:
https://doaj.org/article/17360d8065aa40858299d7f9800c1b56
Publikováno v:
International Journal of Translational Medicine, Vol 3, Iss 1, Pp 120-159 (2023)
Exacerbation of the vascular pathology in radiation retinopathy as a result of pre-existing diabetes has been recognized for many years, as reflected by clinical reports and a few early experimental studies. However, the underlying pathogenetic mecha
Externí odkaz:
https://doaj.org/article/36e0eb3a7bd24400b70b169c2b4795df
Autor:
Tom A. Gardiner, Alan W. Stitt
Publikováno v:
International Journal of Translational Medicine, Vol 2, Iss 1, Pp 26-40 (2022)
Diabetic retinopathy (DR) is the most common complication of diabetes and a major cause of vision loss worldwide. The premature death of the microvascular mural cells represents both a pathological hallmark of vasodegeneration in DR and a basis for t
Externí odkaz:
https://doaj.org/article/be76b930f4544fc5a1c11b7f0a5da2ad
Autor:
Tom A. Gardiner, Alan W. Stitt
Publikováno v:
International Journal of Translational Medicine, Vol 2, Iss 1, Pp 41-50 (2022)
Diabetic retinopathy (DR) remains a prevalent complication of diabetes and a major cause of vision loss among the working population. Selective loss of pericytes and vascular smooth muscle cells (SMCs), the mural cells of the retinal blood vessels, i
Externí odkaz:
https://doaj.org/article/31dded412da34c058fe53976944b2c89
Markers of Hypoxia and Metabolism Correlate With Cell Differentiation in Retina and Lens Development
Publikováno v:
Gardiner, T A, Branagh, T, Tipping, N & McDonald, D M 2022, ' Markers of Hypoxia and Metabolism Correlate With Cell Differentiation in Retina and Lens Development ', Frontiers in Ophthalmology, vol. 2, 867326. . https://doi.org/10.3389/fopht.2022.867326
Recent studies have provided novel insights of co-development of the neural and vascular elements of the retina. Knowledge of these relationships are crucial to understand the impact of therapeutic measures in Retinopathy of Prematurity (ROP). ROP is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa262e991b60953670d2a01b12d33b4f
Autor:
Carmel M McVicar, Liza M Colhoun, Jodie L Abrahams, Claire L Kitson, Ross Hamilton, Reinhold J Medina, Dash Durga, Tom A Gardiner, Pauline M Rudd, Alan W Stitt
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11870 (2010)
BackgroundErythropoiesis stimulating agents (ESAs) are widely used to treat anaemia but concerns exist about their potential to promote pathological angiogenesis in some clinical scenarios. In the current study we have assessed the angiogenic potenti
Externí odkaz:
https://doaj.org/article/1885caee1bc448fabe094558a6c735e6
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2584 (2008)
BackgroundCurrent guidelines encourage the use of statins to reduce the risk of cardiovascular disease in diabetic patients; however the impact of these drugs on diabetic retinopathy is not well defined. Moreover, pleiotropic effects of statins on th
Externí odkaz:
https://doaj.org/article/a2ff1159eaff41ea86bf0e760e742072
Water vapour continuum absorption is potentially important for both closure of the Earth’s energy budget and remote sensing applications. Currently, there are significant uncertainties in its characteristics in the near-infrared atmospheric windows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cdb9bafcd664e58e50ff0da1281023f
https://doi.org/10.5194/amt-2019-403
https://doi.org/10.5194/amt-2019-403
Autor:
Santhi Radha Krishnan, Minu Jenifer Anto, Sudha Priya Soundara Pandi, Anand Rajendran, Tom A. Gardiner, Muthukkaruppan Veerappan, Usha Chakravarthy
Publikováno v:
Indian Journal of Ophthalmology
Indian Journal of Ophthalmology, Vol 69, Iss 3, Pp 642-646 (2021)
Soundara Pandi, S P, Rajendran, A, Radha Krishnan, S, Anto, M J, Gardiner, T, Chakravarthy, U & Veerappan, M 2021, ' Characterization of age-related macular degeneration in Indian donor eyes ', Indian journal of ophthalmology, vol. 69, no. 3, pp. 642-646 . https://doi.org/10.4103/ijo.IJO_291_20
Indian Journal of Ophthalmology, Vol 69, Iss 3, Pp 642-646 (2021)
Soundara Pandi, S P, Rajendran, A, Radha Krishnan, S, Anto, M J, Gardiner, T, Chakravarthy, U & Veerappan, M 2021, ' Characterization of age-related macular degeneration in Indian donor eyes ', Indian journal of ophthalmology, vol. 69, no. 3, pp. 642-646 . https://doi.org/10.4103/ijo.IJO_291_20
Purpose: The purpose of this study was to test the reliability of fundus stereomicroscopy in postmortem eyes to assign severity of age-related macular degeneration (AMD) using the Minnesota grading and confirmation by histology using Alabama and Sark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e162edc4777d109acd146183a4db01
https://doi.org/10.4103/ijo.ijo_291_20
https://doi.org/10.4103/ijo.ijo_291_20