Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tom S. Suhar"'
Autor:
Christine A. Collins, Mei Liu, Hongyu Zhao, Rich S. Janis, Heidi S. Camp, Teresa K. Surowy, Gang Liu, Bo Liu, Nelson Lissa T, Harriet T. Smith, Ning Cao, Tom S. Suhar, Michael D. Serby, Zhili Xin, Hing L. Sham, Bruce G. Szczepankiewicz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4298-4302
A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055af8cecf34aa640b107ce18838c33e
https://doi.org/10.1016/j.bmcl.2008.06.088
https://doi.org/10.1016/j.bmcl.2008.06.088
Autor:
Teresa K. Surowy, Hing L. Sham, Tom S. Suhar, Ning Cao, Michael D. Serby, Heidi S. Camp, Christine A. Collins, Hongyu Zhao, Gang Liu, Harriet T. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3388-3391
A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d07ddf5293e2d8a201e8adcc12320f
https://doi.org/10.1016/j.bmcl.2007.03.099
https://doi.org/10.1016/j.bmcl.2007.03.099
Autor:
Ning Cao, Zhili Xin, Jennifer L. Freeman, Bo Liu, Teresa K. Surowy, Rich S. Janis, Hongyu Zhao, Christine A. Collins, Ruojing Yang, Michael D. Serby, Heidi S. Camp, Tom S. Suhar, Philip R. Kym, David W A Beno, Lynch John K, Gang Liu, Steven P Cepa, Harriet T. Smith, Hing L. Sham, Joel A. Krauser
Publikováno v:
Journal of Medicinal Chemistry. 50:3086-3100
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42af278811a494ed64ae2d19357a5e53
https://doi.org/10.1021/jm070219p
https://doi.org/10.1021/jm070219p
Autor:
Gang Liu, John K. Lynch, Jennifer Freeman, Bo Liu, Zhili Xin, Hongyu Zhao, Michael D. Serby, Philip R. Kym, Tom S. Suhar, Harriet T. Smith, Ning Cao, Ruojing Yang, Rich S. Janis, Joel A. Krauser, Steven P. Cepa, David W. A. Beno, Hing L. Sham, Christine A. Collins, Teresa K. Surowy, Heidi S. Camp
Publikováno v:
Journal of Medicinal Chemistry; Jun2007, Vol. 50 Issue 13, p3086-3100, 15p