Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Tomás R Guilarte"'
Autor:
Xiao-Lei Zhang, Sara R Guariglia, Jennifer L McGlothan, Kirstie H Stansfield, Patric K Stanton, Tomás R Guilarte
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127461 (2015)
Childhood lead (Pb2+) intoxication is a global public health problem and accounts for 0.6% of the global burden of disease associated with intellectual disabilities. Despite the recognition that childhood Pb2+ intoxication contributes significantly t
Externí odkaz:
https://doaj.org/article/90ee2cdab21e4b898a47a1fe5ef3fb92
Publikováno v:
International journal of molecular sciences. 23(21)
Over the last decade, several clinical reports have outlined cases of childhood-onset manganese (Mn)-induced dystonia-parkinsonism, resulting from loss-of-function mutations in the Mn influx transporter gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::776bf411ccd6ef3e4f5300f9dd84c67e
https://pubmed.ncbi.nlm.nih.gov/36361624
https://pubmed.ncbi.nlm.nih.gov/36361624
Publikováno v:
Curr Opin Toxicol
Lead (Pb(2+)) exposure is a global public health problem of major proportion with an alarming number of children with blood Pb(2+) levels > 10 >g/dL, twice the current CDC reference level for Pb(2+) exposure. Mounting evidence from population-based s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14de41d9e96649548b18d99a9300928a
https://doi.org/10.1016/j.cotox.2021.03.007
https://doi.org/10.1016/j.cotox.2021.03.007
Autor:
Damaris Albores-Garcia, Kirstie H. Stansfield, Jennifer L. McGlothan, Zoran Bursac, Tomás R. Guilarte
Publikováno v:
Frontiers in Molecular Neuroscience. 15
Exposure to heavy metals has been associated with psychiatric disorders and recent studies suggest an association between childhood lead (Pb2+) intoxication and schizophrenia (SZ). In animal models, Pb2+ exposure recapitulates key neuropathological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c0c3cd3c64faaaf225226e20e5a90d
https://doi.org/10.3389/fnmol.2022.946726
https://doi.org/10.3389/fnmol.2022.946726
Publikováno v:
Neurotoxicology. 93
Over the last decade, several clinical reports have outlined cases of early-onset manganese (Mn)-induced dystonia-parkinsonism, resulting from loss of function mutations of the Mn transporter gene SLC39A14. Previously, we have performed characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25bc8ff57e64217275b2f96f80b0888
https://pubmed.ncbi.nlm.nih.gov/36152728
https://pubmed.ncbi.nlm.nih.gov/36152728
Autor:
Arlet Maria Acanda de la Rocha, Maggie Fader, Ebony R. Coats, Joseph Dunn, Leat Perez, Carolina Velasquez, Jeanette Galano, Cima Saghira, Ileana Sotto, Yana Vorontsova, Ziad Khatib, Haneen Abdella, Cristina M. Andrade-Feraud, Alexa Jacome, Victoria Reis, Lilliam Rimblas, Nicole Tomas, Paula S. Espinal, Noah Berlow, Tomás R. Guilarte, Jennifer McCafferty-Fernandez, Daria Salyakina, Diana J. Azzam
Publikováno v:
Cancer Research. 83:LB358-LB358
Personalized medicine often serves as the first salvage therapy strategy when standard oncology treatments fail. However, most precision oncology approaches rely on molecular profiling which, unfortunately, provides therapeutic options for less than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57c7ba3b7f62553b6d80a76193d4d6b
https://doi.org/10.1158/1538-7445.am2023-lb358
https://doi.org/10.1158/1538-7445.am2023-lb358
Autor:
Maximilian Schlecht, Tomás R. Guilarte, Maanasa Jayachandran, Nathan W. Schultheiss, Timothy A. Allen, Deborah R. Brooks, Jennifer L. McGlothan
Publikováno v:
Behav Neurosci
Delta-frequency network activity is commonly associated with sleep or behavioral disengagement accompanied by a dearth of cortical spiking, but delta in awake behaving animals is not well understood. We show that hippocampal (HC) synchronization in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0523fb77115b0d57d9a17d9df5682f33
https://doi.org/10.1037/bne0000409
https://doi.org/10.1037/bne0000409
Publikováno v:
Journal of Leukocyte Biology. 110:123-140
Translocator protein 18 kDa (TSPO) is a well-known outer mitochondrial membrane protein and it is widely used as a biomarker of neuroinflammation and brain injury. Although it is thought that TSPO plays key roles in a multitude of host cell functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d13f4c032fd84e3b8e601db2515b6d2
https://doi.org/10.1002/jlb.3a1219-729rr
https://doi.org/10.1002/jlb.3a1219-729rr
Autor:
Deborah A. Cory-Slechta, Anika L. Dzierlenga, Jonathan A. Hollander, Edward D. Levin, Steven T. Szabo, Mady Hornig, Staci D. Bilbo, Julia L. Zehr, Cindy P. Lawler, Felice N. Jacka, Sheryl S. Moy, Ebrahim Haroon, Kimberly A. McAllister, Christine Ladd-Acosta, Mikhail V. Pletnikov, Amanda E. Garton, Tomás R. Guilarte, Carolyn J. Mattingly
Publikováno v:
Neuropsychopharmacology
The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5ba591cd65e7336c87bd63e84a769e
https://doi.org/10.1038/s41386-020-0648-5
https://doi.org/10.1038/s41386-020-0648-5
Publikováno v:
Neurobiology of Disease, Vol 158, Iss, Pp 105467-(2021)
Neurobiol Dis
Neurobiol Dis
Inherited autosomal recessive mutations of the manganese (Mn) transporter gene SLC39A14 in humans, results in elevated blood and brain Mn concentrations and childhood-onset dystonia-parkinsonism. The pathophysiology of this disease is unknown, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c432c16199839b731375ea03ef8f799
http://www.sciencedirect.com/science/article/pii/S0969996121002163
http://www.sciencedirect.com/science/article/pii/S0969996121002163