Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tomáš Racek"'
Autor:
Gino Kwon, Annika Wiedemann, Lisa M. Steinheuer, Ana-Luisa Stefanski, Franziska Szelinski, Tomas Racek, Andreas Philipp Frei, Klas Hatje, Tony Kam-Thong, David Schubert, Thomas Schindler, Thomas Dörner, Kevin Thurley
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) share clinical as well as pathogenic similarities. Although previous studies suggest various abnormalities in different immune cell compartments, dedicated cell-type
Externí odkaz:
https://doaj.org/article/d842d9b1ede44c8c9b4c539caeb38071
Publikováno v:
Journal of Biological Chemistry. 283:34305-34314
The endoplasmic reticulum chaperone GRP78/BIP plays a central role in the prosurvival machinery, and its enhanced expression has been implicated in drug resistance, carcinogenesis, and metastasis. E2F1, as part of an antitumor safeguard mechanism, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d64eff9f0bc1073572f3e48d4b29e4
https://doi.org/10.1074/jbc.m803925200
https://doi.org/10.1074/jbc.m803925200
Publikováno v:
Journal of Molecular Biology. 378:20-30
Hepatitis B virus (HBV) is a causative agent of chronic hepatitis and hepatocellular carcinoma. Recent findings demonstrating p73 and specifically N-terminally truncated p73 (DeltaTAp73) accumulation in hepatocellular carcinoma suggest that p73 plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38493ff2a9a200b2c1a7b7d45176aea
https://doi.org/10.1016/j.jmb.2008.02.021
https://doi.org/10.1016/j.jmb.2008.02.021
Publikováno v:
Virus Research. 114:45-53
Adult neural stem cells (aNSCs) represent an attractive source for the production of specific types of neurons in degenerative CNS diseases and for the development of new regenerative gene therapies. However, the use of adult NSCs for transplantation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389d25abe40589fe2734a13373e7b172
https://doi.org/10.1016/j.virusres.2005.05.010
https://doi.org/10.1016/j.virusres.2005.05.010
Autor:
Ondřej Schindler, Tomáš Raček, Aleksandra Maršavelski, Jaroslav Koča, Karel Berka, Radka Svobodová
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Background Partial atomic charges find many applications in computational chemistry, chemoinformatics, bioinformatics, and nanoscience. Currently, frequently used methods for charge calculation are the Electronegativity Equalization Method (
Externí odkaz:
https://doaj.org/article/169dbc18d0964272ae4286310036a6f8
Autor:
Steve Hildebrandt, Gerd Kempermann, Tomáš Racek, Johanna Scheibe, Anke Schmidt, Andreas Wree, Brigitte M. Pützer, Stefan Jean-Pierre Haas, Birthe Eckhoff
Publikováno v:
Stem cells (Dayton, Ohio). 25(11)
The adult brain contains neural precursor cells (NPC) that are attracted to brain lesions, such as areas of neurodegeneration, ischemia, and cancer. This suggests that NPC engineered to promote lineage-specific differentiation or to express therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a10e518c49c93162ac0900332290cfa
https://pubmed.ncbi.nlm.nih.gov/17641242
https://pubmed.ncbi.nlm.nih.gov/17641242
Publikováno v:
Oncogene. 25(50)
Distinct dominant activating mutations in the RET proto-oncogene are responsible for the development of multiple endocrine neoplasia type 2 (MEN 2). Concise examination of the mutated codons led to the detection of a striking genotype-phenotype corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ea90873cb3da68988a8efe3463ffda
https://pubmed.ncbi.nlm.nih.gov/16715139
https://pubmed.ncbi.nlm.nih.gov/16715139
Adenovirus-mediated TA-p73beta gene transfer increases chemosensitivity of human malignant melanomas
Autor:
Annett Niemetz, Brigitte M. Pützer, Sebastian Tuve, Maria S. Soengas, Julia Schultz, Tomáš Racek
Publikováno v:
Apoptosis : an international journal on programmed cell death. 11(2)
Malignant melanoma is the most aggressive form of skin cancer and has proven to be highly resistant to conventional chemotherapy. Intriguingly, the p53 tumor suppressor, a main mediator of chemoresistance in other tumor types, is rarely mutated in me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cc41586c87bf8c8526a9bc6f61ea78
https://pubmed.ncbi.nlm.nih.gov/16502261
https://pubmed.ncbi.nlm.nih.gov/16502261
Publikováno v:
The Journal of biological chemistry. 280(49)
Activation of telomerase is linked to tumorigenesis and has been observed in a variety of human tumors. Previous reports demonstrated that p53 represses human telomerase reverse transcriptase (hTERT), a key component for telomerase activity. The p73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f1ab44af76e0572bd08a9e675c0dd7
https://pubmed.ncbi.nlm.nih.gov/16234237
https://pubmed.ncbi.nlm.nih.gov/16234237
Autor:
Andrea Luk, Qiudi Jiang, Katerina Glavini, Miriam Triyatni, Na Zhao, Tomas Racek, Yonghong Zhu, Joseph F. Grippo
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 5, Pp 985-993 (2020)
Toll‐like receptor 7 (TLR7) agonists modulate broad spectrum immune activity and are evaluated in the treatment of human diseases, including cancer and chronic viral infection. RO7020531, an oral prodrug of a TLR7 agonist, is in clinical developmen
Externí odkaz:
https://doaj.org/article/990068dfb2064601bbfcaf7fd7ba5971