Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Tomáš Pekárek"'
Publikováno v:
J Pharm Anal
The properties of dry-coated paracetamol particles (fast-dissolving model drug) with carnauba wax particles as the coating agent (dissolution retardant) were investigated. Raman mapping technique was used to non-destructively examine the thickness an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadd4a84cb655e8f21b5640cc3d262e2
https://europepmc.org/articles/PMC10124118/
https://europepmc.org/articles/PMC10124118/
Publikováno v:
Journal of Solution Chemistry. 50:315-339
Bedaquiline (trade name Sirturo) is an antibiotic used to treat pulmonary tuberculosis that is resistant to other antibiotics. The pH-spectrophotometric and pH-potentiometric titrations allowed the measurement of two near successive and one distant d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bee71c5ae7a5633c649c02dcc5cbc640
https://doi.org/10.1007/s10953-021-01055-w
https://doi.org/10.1007/s10953-021-01055-w
Autor:
Bohumil Kratochvíl, Hana Brusová, Jaroslav Havlíček, Izabela Jendrzejewska, Christelle Kadlec, Filip Kadlec, Lucie Krumbholcová, Tomáš Pekárek, Lukáš Plaček, Anna Řezáčová, Dita Spálovská
The textbook provides an overview of the main techniques applied in pharmaceutical industry, with the focus on solid-state analysis. It discusses spectral methods, thermal analysis, and dissolution testing, explains the theoretical background for eac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f20d1354d680d80305de4bb45c95223d
https://doi.org/10.5817/cz.muni.o280-0193-2022
https://doi.org/10.5817/cz.muni.o280-0193-2022
Publikováno v:
Journal of Solution Chemistry. 48:1266-1286
Valsartan is used for treating high blood pressure, congestive heart failure and to increase the chances of living longer after a heart attack and to reduce the mortality rate for people with left ventricular dysfunction following a heart attack. Reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddca5e24c4085b9f0c1ea8466d02b59f
https://doi.org/10.1007/s10953-019-00913-y
https://doi.org/10.1007/s10953-019-00913-y
Publikováno v:
Journal of Solution Chemistry. 48:702-731
Nilotinib hydrochloride (AMN107, TASIGNA, Novartis) is used to treat adults with chronic myeloid leukemia (CML), a type of leukemia. It is a novel, orally active BCR-ABL tyrosine kinase inhibitor derived from aminopyrimidine that is 30 times more eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3eb592fe3b13b66b5a677775268d434
https://doi.org/10.1007/s10953-019-00882-2
https://doi.org/10.1007/s10953-019-00882-2
Autor:
Tereza Školáková, Dominika Smržová, Tomáš Pekárek, Miloslav Lhotka, Andrea Školáková, Vojtěch Klimša, Alena Kadeřábková, Petr Zámostný
Publikováno v:
International Journal of Pharmaceutics. 623:121955
The aim of this study was to investigate the molecular structures of tadalafil solid dispersions prepared by different techniques and further to relate them to surface free energy information indicating the final amorphousness of the product. Thus, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d5a23a423b7d5ce7732126c220ec93
https://doi.org/10.1016/j.ijpharm.2022.121955
https://doi.org/10.1016/j.ijpharm.2022.121955
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 209:114496
Raman micro-spectroscopy technique offers a combination of relatively high spatial resolution with identification of components or mixtures of components in different sample areas, e.g. on the surface or the cross-section of a sample. This study is f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2830b82869442aa9a384690c4b23d9c
https://doi.org/10.1016/j.jpba.2021.114496
https://doi.org/10.1016/j.jpba.2021.114496
Publikováno v:
Journal of Drug Delivery Science and Technology. 47:386-394
Pharmaceutical tablets contain a variety of active substances and excipients which could be monitored by Raman spectroscopy/microscopy. Raman microscopic spectra are affected not only by the sample composition but also by preparation/measurement cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29e38b260d206dc98efd9548fc2bce1
https://doi.org/10.1016/j.jddst.2018.08.002
https://doi.org/10.1016/j.jddst.2018.08.002
Publikováno v:
Journal of Molecular Liquids. 268:386-402
The dissociation constant pKa of the Roxadustat with UV-VIS spectra, molar absorption coefficients and protonation equilibria are the key physicochemical parameters influencing many biopharmaceutical characteristics. Roxadustat is an orally bioavaila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510d297aba346978f76e4403c3ca486c
https://doi.org/10.1016/j.molliq.2018.07.076
https://doi.org/10.1016/j.molliq.2018.07.076
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 158:236-246
Potentiometric and spectrophotometric pH-titrations of the lesinurad for three consecutive dissociation constants determination were compared. Lesinurad is a selective inhibitor of uric acid reabsorption as part of a combination of medicines to treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a09371ef40cc930f0aad6bca7a4064
https://doi.org/10.1016/j.jpba.2018.05.047
https://doi.org/10.1016/j.jpba.2018.05.047