Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomáš Janovič"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-stranded breaks (DSBs) in vertebrates. However, due to challenges in detecting DSBs in living cells, the repair capacity of the NHEJ pathway is unknown. The
Externí odkaz:
https://doaj.org/article/762942600f0844a6ad8f1db2cc791d1d
Autor:
Pavel Veverka, Tomáš Brom, Tomáš Janovič, Martin Stojaspal, Matyáš Pinkas, Jiří Nováček, Ctirad Hofr
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 731-741 (2023)
The RE1-Silencing Transcription factor (REST) is essential for neuronal differentiation. Here, we report the first 18.5-angstrom electron microscopy structure of human REST. The refined electron map suggests that REST forms a torus that can accommoda
Externí odkaz:
https://doaj.org/article/b48056cabad64263a7e4df55e6f78ad0
Autor:
Jiri Novacek, Pavel Veverka, Tomas Brom, Matyas Pinkas, Ctirad Hofr, Tomáš Janovič, Martin Stojaspal
The RE1-Silencing Transcription factor (REST) is essential for neuronal differentiation. Here, we report the first 18.5-angstrom electron microscopy structure of human REST. The refined electron map suggests that REST forms a torus that can accommoda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6c97ccb64b22458d0a54f6dc81d45d
https://doi.org/10.1101/2022.10.06.511111
https://doi.org/10.1101/2022.10.06.511111
Publikováno v:
NAR cancer. 4(1)
Transcription is often the first biosynthetic event of viral infection. Viruses produce preferentially viral transcriptional regulators (vTRs) essential for expressing viral genes and regulating essential host cell proteins to enable viral genome rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5206de95e3d64d175b9b33b74bf52753
https://pubmed.ncbi.nlm.nih.gov/35252867
https://pubmed.ncbi.nlm.nih.gov/35252867
Autor:
Lenka Kubinyiová, Ján Tóth, Ctirad Hofr, Štěpán Káňa, Petr Táborský, Tomáš Janovič, Josef Kučera, Ondřej Peš
Publikováno v:
Sensors and Actuators B: Chemical. 352:131029
The fluorescence signal increase in deuterated water - D2O is relevant to many methods used in chemical and biological research. We performed fluorescence spectroscopy measurements combined with evaluations of fluorescence-based methods to describe a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abfbb34ff349a392ad672d4f44834bfb
https://doi.org/10.1016/j.snb.2021.131029
https://doi.org/10.1016/j.snb.2021.131029
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3186 (2019)
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3186 (2019)
The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8614c28b69e858dd73ca5bfa3e8ea9c5
https://pubmed.ncbi.nlm.nih.gov/31261825
https://pubmed.ncbi.nlm.nih.gov/31261825
Human telomeric repeat binding factors TRF1, TRF2 along with TIN2 form a core of shelterin complex that protects chromosome ends against unwanted end-joining and DNA repair. We applied a single-molecule approach to assess TRF1-TIN2-TRF2 complex forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbd90f358d65664adee4db92228ae15