Výsledky vyhledávání - "Tomáš Hauser"

Akademický článek

Development of immediate‐release formulation with reliable absorption of rivaroxaban in various meal regimes

Autor: Jan Bosák, Martin Šíma, Tereza Krejčí, Iva Obadalová, Jaroslava Šmardová, Petr Kozlík, Tomáš Křížek, Josef Beránek, Tomáš Hauser, Ondřej Slanař

Publikováno v: Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)

Abstract The bioavailability of rivaroxaban at the higher doses (15 and 20 mg) is considerably reduced when the drug is administered on an empty stomach. This can lead to inadequate anticoagulant effect, and therefore, it is recommended to use the hi

Externí odkaz: https://doaj.org/article/a5bac16325a84301bee9ca4ced8a4c8a

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Akademický článek

Crushing tablets or sprinkling capsules: Implications for clinical strategy and study performance based on BE studies of rivaroxaban and deferasirox

Autor: Jan Sus, Jan Bosak, Tomas Hauser

Publikováno v: Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)

Abstract Administration of oral medicinal products as crushed tablets or open capsules is an important delivery option for patients suffering from dysphagia. To obtain full interchangeability of generics with the original products, demonstration of b

Externí odkaz: https://doaj.org/article/a6dbdee55289494680ab7998ca68d139

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Akademický článek

The bioequivalence of fixed‐dose combination tablets of bisoprolol and ramipril and its drug‐drug interaction potential

Autor: Jan Sus, Jade Huguet, Jan Bosak, Beatrice Setnik, Tomas Hauser, Eric Sicard

Publikováno v: Clinical and Translational Science, Vol 15, Iss 1, Pp 158-171 (2022)

Abstract Chronic antihypertensive treatment often includes combination of two or more therapies with complementary mechanism of action targeting different blood pressure (BP) control system. If available, these components are recommended to be admini

Externí odkaz: https://doaj.org/article/01aeca5cff574e07b9bc6d15176b77c4

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Single-dose, 2-way crossover, bioequivalence study of two rosuvastatin formulations in normal healthy subjects under fasting conditions

Autor: Raphaël Vlavonou, Tomáš Hauser, Fethi Trabelsi, Lucie Navrátilová, Mario Tanguay, Charlotte Dubé, Aleš Bartůnek

Publikováno v: Int. Journal of Clinical Pharmacology and Therapeutics.

Background Rosuvastatin, a synthetic lipid-lowering agent acts selectively by competitive inhibition of 3-hydroxy- 3-methylglutaryl-coenzyme A. It is indicated as an adjunct to diet in patients with hypercholesterolemia and mixed dyslipidemia. Object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79322da2a1e5a7035c22d9cd7d100f30
https://doi.org/10.5414/cp201687

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