Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tomáš Cihlář"'
Autor:
Nadine A. Peart Akindele, Laharika Dasharath Katamoni, Jacqueline Brockhurst, Shristi Ghimire, San Suwanmanee, Lisa Pieterse, Kelly A. Metcalf Pate, Elaine Bunyan, Roy Bannister, Tomas Cihlar, Danielle P. Porter, Diane E. Griffin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Measles is a systemic disease initiated in the respiratory tract with widespread measles virus (MeV) infection of lymphoid tissue. Mortality can be substantial, but no licensed antiviral therapy is available. We evaluated both post-exposure
Externí odkaz:
https://doaj.org/article/76a85a9a195b495cbfb6351adcec7877
Autor:
Sheli R. Radoshitzky, Patrick Iversen, Xianghan Lu, Jing Zou, Suzanne J. F. Kaptein, Kelly S. Stuthman, Sean A. Van Tongeren, Jesse Steffens, Ruoyu Gong, Hoa Truong, Annapurna A. Sapre, Huiling Yang, Xiaodong Xie, Jia Jun Chia, Zhijuan J. Song, Stacey M. Leventhal, Josolyn Chan, Alex Shornikov, Xin Zhang, David Cowfer, Helen Yu, Travis Warren, Tomas Cihlar, Danielle P. Porter, Johan Neyts, Pei-Yong Shi, Jay Wells, John P. Bilello, Joy Y. Feng
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells and metabolized in multiple steps to form the active nucleoside triphosphate (GS-44
Externí odkaz:
https://doaj.org/article/ee7f5fe788f0477a9009a8f32e4eeffd
Autor:
Jan Konvalinka, Tomáš Cihlář, Dorien de Jong, Kirsten M. Stray, Jiří Brynda, Noortje M van Maarseveen, Milan Kožíšek, Pavlína Řezáčová, Monique Nijhuis, Klára Grantz Šašková
Publikováno v:
Journal of Virology. 88:3586-3590
Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ba262e3a3a6bcd9e4f345c7962320d
https://doi.org/10.1128/jvi.02688-13
https://doi.org/10.1128/jvi.02688-13
Autor:
Gina Bahador, Pavla Perlíková, Tomáš Cihlář, Petr Nauš, Aurelie Bourderioux, Radek Pohl, Michal Hocek, Ivan Votruba, Gabriel Birkus, Lenka Poštová Slavětínská
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5202-5214
A series of novel sugar-modified derivatives of cytostatic 7-hetaryl-7-deazaadenosines (2 ′ - C -methylribonucleosides, 2 ′ -deoxy-2 ′ -fluoroarabinonucleosides, arabinonucleosides and 2 ′ -deoxyribonucleosides) was prepared and screened for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd2625cf81b00dc81a142adebddee74
https://doi.org/10.1016/j.bmc.2012.07.003
https://doi.org/10.1016/j.bmc.2012.07.003
Autor:
Elizabeth E. Zumbrun, Carly B. Garvey, Jay B. Wells, Ginger C. Lynn, Sean Van Tongeren, Jesse T. Steffens, Kelly S. Wetzel, Laura M. Gomba, Kristan A. O’Brien, Franco D. Rossi, Xiankun Zeng, Eric D. Lee, Jo Lynne W. Raymond, Diana A. Hoffman, Alexandra N. Jay, Elizabeth S. Brown, Paul A. Kallgren, Sarah L. Norris, Jean Cantey-Kiser, Humza Kudiya, Chris Arthur, Christiana Blair, Darius Babusis, Victor C. Chu, Bali Singh, Roy Bannister, Danielle P. Porter, Tomas Cihlar, John M. Dye
Publikováno v:
Viruses, Vol 15, Iss 12, p 2335 (2023)
Marburg virus (MARV) causes severe disease and high mortality in humans. The objective of this study was to characterize disease manifestations and pathogenesis in cynomolgus macaques exposed to MARV. The results of this natural history study may be
Externí odkaz:
https://doaj.org/article/888ce560fbcf4156b170e652f06b91dc
Autor:
Robert M. Cox, Josef D. Wolf, Carolin M. Lieber, Julien Sourimant, Michelle J. Lin, Darius Babusis, Venice DuPont, Julie Chan, Kim T. Barrett, Diane Lye, Rao Kalla, Kwon Chun, Richard L. Mackman, Chengjin Ye, Tomas Cihlar, Luis Martinez-Sobrido, Alexander L. Greninger, John P. Bilello, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2
Externí odkaz:
https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f4683
Autor:
Travis K. Warren, Christopher D. Kane, Jay Wells, Kelly S. Stuthman, Sean A. Van Tongeren, Nicole L. Garza, Ginger Donnelly, Jesse Steffens, Laura Gomba, Jessica M. Weidner, Sarah Norris, Xiankun Zeng, Roy Bannister, Tomas Cihlar, Sina Bavari, Danielle P. Porter, Patrick L. Iversen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory l
Externí odkaz:
https://doaj.org/article/8b24a8ac056941f5a1d728fbbaf1db9c
Autor:
Ivan Rosenberg, Tomáš Cihlář
Publikováno v:
Journal of Chromatography A. 644:299-305
Chromatographic conditions for the separation of twelve purine and pyrimidine ribonucleotides (mono-, di- and triphosphates) by ion- exchange chromatography were investigated. Two types of anion exchangers with tertiary or quaternary ammonium functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02b75770e6e3cc1f9d1035b6bd9d24de
https://doi.org/10.1016/0021-9673(93)80712-h
https://doi.org/10.1016/0021-9673(93)80712-h
Autor:
Pavla Perlíková, Ivan Votruba, Tomáš Cihlář, Michal Hocek, Radek Pohl, Gabriel Birkus, Robert Shih
Publikováno v:
Bioorganicmedicinal chemistry. 19(1)
A series of O-phenyl methyl-, ethyl- and benzylalanyl phosphoramidate pronucleotides derived from cytostatic 6-aryl-7-deazapurine ribonucleosides were prepared by the cross-coupling reactions of the 2',3'-isopropylidene protected 6-chloro-7-deazapuri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7803cb378cddeb861d8cc7d3c652a76
https://pubmed.ncbi.nlm.nih.gov/21134754
https://pubmed.ncbi.nlm.nih.gov/21134754
Autor:
Xuping Xie, Antonio E. Muruato, Xianwen Zhang, Kumari G. Lokugamage, Camila R. Fontes-Garfias, Jing Zou, Jianying Liu, Ping Ren, Mini Balakrishnan, Tomas Cihlar, Chien-Te K. Tseng, Shinji Makino, Vineet D. Menachery, John P. Bilello, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
A high-throughput platform would greatly facilitate coronavirus disease 2019 (COVID-19) serological testing and antiviral screening. To address this, Shi and colleagues present a high-throughput nanoluciferase severe respiratory syndrome coronavirus
Externí odkaz:
https://doaj.org/article/2bbb94f095f34ea1ad62d72c16d57318