Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Tomáš Šimůnek"'
Autor:
Pavlína Hašková, Lenka Applová, Hana Jansová, Pavel Homola, Katherine J. Franz, Kateřina Vávrová, Jaroslav Roh, Tomáš Šimůnek
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Labile redox-active iron ions have been implicated in various neurodegenerative disorders, including the Parkinson's disease (PD). Iron chelation has been successfully used in clinical practice to manage iron overload in diseases such as tha
Externí odkaz:
https://doaj.org/article/99dcb27e005f4befb537f7248b8ef357
Autor:
Hana Bavlovič Piskáčková, Hana Jansová, Jan Kubeš, Galina Karabanovich, Nela Váňová, Petra Kollárová-Brázdová, Iuliia Melnikova, Anna Jirkovská, Olga Lenčová-Popelová, Jaroslav Chládek, Jaroslav Roh, Tomáš Šimůnek, Martin Štěrba, Petra Štěrbová-Kovaříková
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 has been previously identified as a more potent analog of dexrazoxane (ICRF-187), a drug used in clinical practice against anthracycline cardiotoxicity. However, the poor aqueous s
Externí odkaz:
https://doaj.org/article/5b4e58f79de6467488f64f6509b130b3
Autor:
Eliška Potůčková, Jaroslav Roh, Miloslav Macháček, Sumit Sahni, Ján Stariat, Vít Šesták, Hana Jansová, Pavlína Hašková, Anna Jirkovská, Kateřina Vávrová, Petra Kovaříková, Danuta S Kalinowski, Des R Richardson, Tomáš Šimůnek
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139929 (2015)
Cancer cells have a high iron requirement and many experimental studies, as well as clinical trials, have demonstrated that iron chelators are potential anti-cancer agents. The ligand, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT), demonstrat
Externí odkaz:
https://doaj.org/article/32e0e5c048be40ea9b144abca457a50c
Publikováno v:
Acta Medica, Vol 48, Iss 3, Pp 127-135 (2005)
Iron is an essential element involved in many life-necessary processes. Interestingly, in mammals there is no active excretion mechanism for iron. Therefore iron kinetics has to be meticulously regulated. The most important step for regulation of iro
Externí odkaz:
https://doaj.org/article/1a1e5f77b63c436393cdde93a75a1b73
Autor:
Michaela Adamcová, Martin Štěrba, Ivona Klimtová, Tomáš Šimůnek, Radomír Hrdina, Vladimír Geršl, Přemysl Poňka
Publikováno v:
Acta Medica, Vol 46, Iss 4, Pp 171-174 (2003)
Both cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are considered to be reliable biomarkers with sufficient sensitivity and specificity for cardiac injury in the majority of laboratory animals. The aim of our study was to compare the diagno
Externí odkaz:
https://doaj.org/article/60abc12410fc4255a2de72aabe65f890
Autor:
Ivona Klimtová, Tomáš Šimůnek, Yvona Mazurová, Jana Kaplanová, Martin Štěrba, Radomír Hrdina, Vladimír Geršl, Michaela Adamcová, Přemysl Poňka
Publikováno v:
Acta Medica, Vol 46, Iss 4, Pp 163-170 (2003)
Salicylaldehyde Isonicotinoyl Hydrazone (SIH) – a Pyridoxal Isonicotinoyl Hydrazone (PIH) analogue – is an effective iron chelator with antioxidant and antimalarial effects, as documented in numerous in vitro studies. However, no toxicological da
Externí odkaz:
https://doaj.org/article/5d7f21374a1f4a71a5ef14fcc1d36e6d
Autor:
Michaela Adamcová, Vladimír Geršl, Jarmila Macháčková, Radomír Hrdina, Ivona Klimtová, Tomáš Šimůnek, Jaroslava Vávrová, Josef Bukač
Publikováno v:
Acta Medica, Vol 45, Iss 1, Pp 29-32 (2002)
The aim of our study was to compare the diagnostic performance of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in three groups of rabbits: 1) control (saline 1 ml/kg i.v.); 2) daunorubicin (3 mg/kg i.v.); 3) daunorubicin (3 mg/kg i.v.) + d
Externí odkaz:
https://doaj.org/article/80199461503d40b8af0c77ccf4f7dfaf
Autor:
Radomír Hrdina, Vladimír Geršl, Ivona Klimtová, Tomáš Šimůnek, Yvona Mazurová, Jarmila Macháčková, Michaela Adamcová
Publikováno v:
Acta Medica, Vol 45, Iss 3, Pp 99-105 (2002)
A possible protective action of DMPS (a dithiol chelating agent) against chronic daunorubicin toxicity in rabbits in comparison with dexrazoxane was investigated. The rabbits were divided into five groups: control (saline, 1 ml/kg i.v.), daunorubicin
Externí odkaz:
https://doaj.org/article/f247b4fcceab4ee5b6f3e11f5be3ab93
Publikováno v:
Pharmacy, Vol 5, Iss 4, p 54 (2017)
The PHARMINE (“Pharmacy Education in Europe”) project studied the organisation of pharmacy education, practice and legislation in the European Union (EU) with the objectives of evaluating to what degree harmonisation had taken place with the EU,
Externí odkaz:
https://doaj.org/article/ba5d5fd582454aec82244a73fc4798fa
Autor:
Olga Lenčová-Popelová, Eduard Jirkovský, Yvona Mazurová, Juraj Lenčo, Michaela Adamcová, Tomáš Šimůnek, Vladimír Geršl, Martin Štěrba
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96055 (2014)
Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular determinants of the toxic damage and associated myocardial remodeling remain to be established. Fu
Externí odkaz:
https://doaj.org/article/657045e254634bf9a8a3e66542998055