Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Tomáš, Křížek"'
Autor:
Jan Bosák, Martin Šíma, Tereza Krejčí, Iva Obadalová, Jaroslava Šmardová, Petr Kozlík, Tomáš Křížek, Josef Beránek, Tomáš Hauser, Ondřej Slanař
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract The bioavailability of rivaroxaban at the higher doses (15 and 20 mg) is considerably reduced when the drug is administered on an empty stomach. This can lead to inadequate anticoagulant effect, and therefore, it is recommended to use the hi
Externí odkaz:
https://doaj.org/article/a5bac16325a84301bee9ca4ced8a4c8a
Autor:
Jiří Pozniak, Pavel Ryšánek, David Smrčka, Petr Kozlík, Tomáš Křížek, Jaroslava Šmardová, Anežka Nováková, Debanjan Das, Daniel Bobek, Mahak Arora, Jiří Hofmann, Tereza Doušová, Martin Šíma, Ondřej Slanař
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Ivacaftor is a modern drug used in the treatment of cystic fibrosis. It is highly lipophilic and exhibits a strong positive food effect. These characteristics can be potentially connected to a pronounced lymphatic transport after oral adm
Externí odkaz:
https://doaj.org/article/a97021bba87c4ffb97563ac5f4adf948
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101336- (2024)
This article demonstrates the potential of electrochemical oxidation as an alternative approach to studying the effect of oxidation on active pharmaceutical ingredients. The performance and the outcomes of the electrochemical approach are compared to
Externí odkaz:
https://doaj.org/article/32b986cfd48e48689357b5b069df5e83
Autor:
Alena Libánská, Tomáš Špringer, Lucie Peštová, Kevin Kotalík, Rafał Konefał, Alice Šimonová, Tomáš Křížek, Jiří Homola, Eva Randárová, Tomáš Etrych
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Nanomedicines, including polymer nanocarriers with controlled drug release, are considered next-generation therapeutics with advanced therapeutic properties and reduced side effects. To develop safe and efficient nanomedicines, it is crucial
Externí odkaz:
https://doaj.org/article/f26bc3d23c05402cb6b63f3b3eeaded9
Autor:
Veronika Hýsková, Michal Jakl, Jana Jaklová Dytrtová, Sanja Ćavar Zeljković, Ondřej Vrobel, Kateřina Bělonožníková, Daniel Kavan, Tomáš Křížek, Alice Šimonová, Marie Vašková, Ishak Kovač, Antoniana Račko Žufić, Helena Ryšlavá
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 268, Iss , Pp 115729- (2023)
Several 1,2,4-triazoles are widely used as systemic fungicides in agriculture because they inhibit fungal 14ɑ-demethylase. However, they can also act on many non-target plant enzymes, thereby affecting phytohormonal balance, free amino acid content,
Externí odkaz:
https://doaj.org/article/f5d2cf4eac374ed59c93ff93a6ab9bee
Autor:
Alexander Dushkov, Zuzana Vosáhlová, Alexander Tzintzarov, Květa Kalíková, Tomáš Křížek, Iva Ugrinova
Publikováno v:
Molecules, Vol 28, Iss 19, p 6824 (2023)
The fungus Amanita muscaria is universally recognizable for its iconic appearance; it is also widely regarded as poisonous, inedible, and even deadly. In spite of that, there have been documented cases of use of A. muscaria-containing preparations ag
Externí odkaz:
https://doaj.org/article/dd49214e8e634d2fade31201bbbe87fe
Autor:
Veronika Hýsková, Michal Jakl, Jana Jaklová Dytrtová, Sanja Ćavar Zeljković, Ondřej Vrobel, Kateřina Bělonožníková, Daniel Kavan, Tomáš Křížek, Alice Šimonová, Marie Vašková, Ishak Kovač, Antoniana Račko Žufić, Helena Ryšlavá
Publikováno v:
Metabolites, Vol 13, Iss 9, p 988 (2023)
Triazole fungicides can threaten plants as abiotic stressors but can also positively affect plant defense by inducing priming. Thus, plant yield is also both protected and endangered by triazoles that may influence several metabolic pathways during m
Externí odkaz:
https://doaj.org/article/9c8db5fa6d8b4b1b9eae7a3c47e7e067
Autor:
Viktor Kožich, Bernd C Schwahn, Jitka Sokolová, Michaela Křížková, Tamas Ditroi, Jakub Krijt, Youssef Khalil, Tomáš Křížek, Tereza Vaculíková-Fantlová, Blanka Stibůrková, Philippa Mills, Peter Clayton, Kristýna Barvíková, Holger Blessing, Jolanta Sykut-Cegielska, Carlo Dionisi-Vici, Serena Gasperini, Ángeles García-Cazorla, Tobias B Haack, Tomáš Honzík, Pavel Ješina, Alice Kuster, Lucia Laugwitz, Diego Martinelli, Francesco Porta, René Santer, Guenter Schwarz, Peter Nagy
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102517- (2022)
Regulation of H2S homeostasis in humans is poorly understood. Therefore, we assessed the importance of individual enzymes in synthesis and catabolism of H2S by studying patients with respective genetic defects. We analyzed sulfur compounds (including
Externí odkaz:
https://doaj.org/article/c104284c656d4baba6f0fc3dc95350b4
Publikováno v:
Prague Medical Report, Vol 121, Iss 4, Pp 244-253 (2020)
The post-mortem toxicological findings may be misinterpreted, if the drug undergoes substantial post-mortem redistribution. As alprazolam is one of the most frequently evaluated drug for legal/forensic reasons in drug-related fatalities, we studied p
Externí odkaz:
https://doaj.org/article/f7ec6188efd84794b1fd3d892355da40
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 25 (2021)
Purpose: Statin therapy should be considered in children with familial hypercholesterolemia and sustained high LDL-C levels. There are no data on rosuvastatin exposure in patients
Externí odkaz:
https://doaj.org/article/97b925433d01477cbd0fb2daef112c9c