Enantiospecific tritium labeling of 28-homocastasterone

Autor: Mahadeo R. Patil, Aleš Marek, Tomáš Elbert

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 60:176-182

A regiospecific and enantiospecific synthesis of tritium-labeled 28-homocastasterone is reported. Appropriate chlorocarbonate, efficiently synthesized from the starting 28-homocastasterone in an overall yield of 46%, undergoes catalytic tritium dechl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e29b65b0b0754116d76d0b9d6d85fd4
https://doi.org/10.1002/jlcr.3488

The labeling of unsaturated γ-hydroxybutyric acid by heavy isotopes of hydrogen: iridium complex-mediated H/D exchange by C─H bond activation vs reduction by boro-deuterides/tritides

Autor: Tomáš Elbert, Bente Frølund, Stine B. Vogensen, Aleš Marek, Martin Holst Friborg Pedersen, Rasmus P. Clausen

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 59:476-483

3-Hydroxycyclopent-1-ene-1-carboxylic acid (HOCPCA (1)) is a potent ligand for high-affinity γ-hydroxybutyric acid binding sites in the central nervous system. Various approaches to the introduction of a hydrogen label onto the HOCPCA skeleton are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06c44578302342bc8eeefa64e643a1d7
https://doi.org/10.1002/jlcr.3432

Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand

Autor: Anne Cathrine Nøhr, Hans Bräuner-Osborne, Anders B. Klein, Sebastiaan Kuhne, Aleš Marek, Daniel Sejer Pedersen, Tomáš Elbert, Petrine Wellendorph

Publikováno v: Kuhne, S, Nøhr, A C, Marek, A, Elbert, T, Klein, A B, Bräuner-Osborne, H, Wellendorph, P & Pedersen, D S 2016, ' Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand ', RSC Advances, vol. 6, no. 2, pp. 947-952 . https://doi.org/10.1039/c5ra21326f
RSC Advances, 6(2), 947-952. Royal Society of Chemistry

Compound 1 is a selective and potent agonist of the G protein-coupled receptor GPR139 (EC50 = 39 nM). In this study, we describe the synthesis, radiolabelling and in vitro evaluation of [3H]-1 for the characterisation of GPR139 and its spatial expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be350878a5bb43c9a7d4bbb0afe878e
https://hdl.handle.net/1871.1/1fd3df13-53a0-4819-8975-bb6261679431

A facile method for steroid labeling by heavy isotopes of hydrogen

Autor: Blanka Klepetářová, Tomáš Elbert, Aleš Marek

Publikováno v: Tetrahedron. 71:4874-4882

A new catalytic enantiospecific approach to the synthesis of epibrassinosteroids (and other polyhydroxylated steroids) regiospecifically labeled by heavy isotopes of hydrogen is reported. Chlorocarbonate, efficiently synthesized from α-hydroxy keton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23f9d7e2decc711d94a838d3bb479cb9
https://doi.org/10.1016/j.tet.2015.04.099

Labelling of brassinosteroids by isotopes of hydrogen and carbon

Autor: Mahadeo R. Patil, Tomáš Elbert, Rangappa S. Keri

Publikováno v: RSC Advances. 5:39726-39745

The brassinosteroids (BRs) are a class of native plant growth regulating substances with high biological activity even at very low concentration. These compounds have been rigorously explored and it has been found that they are not only growth regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd6f37b84e9a7bf5a1b5274006b6d909
https://doi.org/10.1039/c5ra04081g