Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tomàs Jordà-Siquier"'
Autor:
Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Mutations in presenilin, which cleaves amyloid precursor protein, cause familial Alzheimer’s Disease. Here, the authors show that loss of presenilin leads to loss of synaptotagmin 7, leading to impaired presynaptic release.
Externí odkaz:
https://doaj.org/article/9141dd69adf04d1c8a0ace613a53f522
Autor:
Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
The use of human post-mortem brain material is of great value when investigating which pathological mechanisms occur in human brain, and to avoid translational problems which have for example been evident when translating animal research into Alzheim
Externí odkaz:
https://doaj.org/article/e2b58afc23234ecf8a2fb5d7b085315d
Autor:
Tomàs Jordà‐Siquier, Melina Petrel, Vladimir Kouskoff, Una Smailovic, Fabrice Cordelières, Susanne Frykman, Ulrike Müller, Christophe Mulle, Gaël Barthet
Publikováno v:
Alzheimer's & Dementia. 18:2099-2116
In Alzheimer's disease (AD), the distribution of the amyloid precursor protein (APP) and its fragments other than amyloid beta, has not been fully characterized. Here, we investigate the distribution of APP and its fragments in human AD brain samples
Autor:
Christophe Mulle, Bengt Winblad, Gaël Barthet, Hazal Haytural, Ann-Charlotte Granholm, Tomàs Jordà-Siquier, Lars O. Tjernberg, Susanne Frykman
Publikováno v:
Brain Communications
Synaptic degeneration has been reported as one of the best pathological correlates of cognitive deficits in Alzheimer’s disease. However, the location of these synaptic alterations within hippocampal sub-regions, the vulnerability of the presynapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca77ca697574e08647d08308d911f1a
https://doi.org/10.1101/2020.10.06.327833
https://doi.org/10.1101/2020.10.06.327833
Autor:
Susanne Frykman, Christophe Mulle, Melina Petrel, Vladimir Kouskoff, Tomàs Jordà-Siquier, Ulrike Müller, Gaël Barthet, Fabrice P. Cordelières
SummaryIn Alzheimer’s disease (AD), a central role is given to the extracellular deposition of Aβ peptides, remotely produced by the proteolysis of the amyloid precursor protein (APP). This contrasts with other neurodegenerative diseases which are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18d574af74cfcf7b8cbebde048bf4be
Autor:
Tomàs Jordà-Siquier, Erik Sundström, Hazal Haytural, Susanne Frykman, Jolanta L. Lundgren, Bengt Winblad, Marinela Kalcheva, Mohammed Seed Ahmed, Lars O. Tjernberg, Gaël Barthet, Tansu B. Köse
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
The use of human post-mortem brain material is of great value when investigating which pathological mechanisms occur in human brain, and to avoid translational problems which have for example been evident when translating animal research into Alzheim
Autor:
A.M. Thierry, Tomàs Jordà Siquier, Angela Engel, Jean-Michel Deniau, Henk J. Groenewegen, Floris G. Wouterlood, Yvette C van Dongen, Aileen Meinderts, Jørgen Scheel-Krüger, Mariah Daal, Jeroen A.M. Beliën, Gertjan Houwen
Publikováno v:
Journal of Neuroscience Research, 96(9), 1518-1542. Wiley-Liss Inc.
Wouterlood, F G, Engel, A, Daal, M, Houwen, G, Meinderts, A, Jordà Siquier, T, Beliën, J A M, van Dongen, Y C, Scheel-Krüger, J, Thierry, A-M, Groenewegen, H J & Deniau, J-M 2018, ' Mesencephalic dopamine neurons interfacing the shell of nucleus accumbens and the dorsolateral striatum in the rat ', Journal of Neuroscience Research, vol. 96, no. 9, pp. 1518-1542 . https://doi.org/10.1002/jnr.24242
Journal of Neuroscience Research
Wouterlood, F G, Engel, A, Daal, M, Houwen, G, Meinderts, A, Jordà Siquier, T, Beliën, J A M, van Dongen, Y C, Scheel-Krüger, J, Thierry, A-M, Groenewegen, H J & Deniau, J-M 2018, ' Mesencephalic dopamine neurons interfacing the shell of nucleus accumbens and the dorsolateral striatum in the rat ', Journal of Neuroscience Research, vol. 96, no. 9, pp. 1518-1542 . https://doi.org/10.1002/jnr.24242
Journal of Neuroscience Research
Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional‐motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1b6dcfd667ce48049eecf74ce4885a
https://research.vumc.nl/en/publications/51b2dab0-1335-41ea-99bb-96ba7462ffdb
https://research.vumc.nl/en/publications/51b2dab0-1335-41ea-99bb-96ba7462ffdb