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Akademický článek

Analysis of 1386 epileptogenic brain lesions reveals association with DYRK1A and EGFR

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

Abstract Lesional focal epilepsy (LFE) is a common and severe seizure disorder caused by epileptogenic lesions, including malformations of cortical development (MCD) and low-grade epilepsy-associated tumors (LEAT). Understanding the genetic etiology

Externí odkaz: https://doaj.org/article/70232dfff20a4c2b91b969f5ee771baa

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Akademický článek

Age‐dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy

Autor: Annika Lehner, Lucas Hoffmann, Stefan Rampp, Roland Coras, Friedrich Paulsen, Renato Frischknecht, Hajo Hamer, Katrin Walther, Sebastian Brandner, Wiebke Hofer, Tom Pieper, Lea‐Marie Reisch, Christian G. Bien, Ingmar Blumcke

Publikováno v: Epilepsia Open, Vol 9, Iss 4, Pp 1372-1381 (2024)

Abstract Objective Perineuronal nets (PNN) are specialized extracellular matrix (ECM) components of the central nervous system, frequently accumulating at the surface of inhibitory GABAergic interneurons. While an altered distribution of PNN has been

Externí odkaz: https://doaj.org/article/3930e1b8c68e483ca7b812230031882d

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Akademický článek

Deep histopathology genotype–phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-11 (2023)

Abstract Focal cortical dysplasia type II (FCDII) is the most common cause of drug-resistant focal epilepsy in children. Herein, we performed a deep histopathology-based genotype–phenotype analysis to further elucidate the clinico-pathological and

Externí odkaz: https://doaj.org/article/4bef610997d24176a5d187b82505fdf0

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Akademický článek

Generation of Chimeric Antigen Receptors against Tetraspanin 7

Autor: Tom Pieper, Kristian Daniel Ralph Roth, Viktor Glaser, Tobias Riet, Laura Elisa Buitrago-Molina, Maike Hagedorn, Maren Lieber, Michael Hust, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski

Publikováno v: Cells, Vol 12, Iss 11, p 1453 (2023)

Adoptive transfer of antigen-specific regulatory T cells (Tregs) has shown promising results in the treatment of autoimmune diseases; however, the use of polyspecific Tregs has limited effects. However, obtaining a sufficient number of antigen-specif

Externí odkaz: https://doaj.org/article/2290f40ad4254c9d8cd3659fc1a59533

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Hypothalamic hamartoma associated with polymicrogyria and periventricular nodular heterotopia in children: report of three cases and discussion of the origin of the seizures

Autor: Martine Fohlen, Delphine Taussig, Jerry Blustajn, Serge Rivera, Tom Pieper, Sarah Ferrand-Sorbets, Georg Dorfmuller

Publikováno v: Child's Nervous System. 38:1965-1975

Hypothalamic hamartomas (HH) are malformations responsible for drug-resistant epilepsy. HH are usually isolated or part of a genetic syndrome, such as Pallister-Hall. Exceptionally they can be associated with other brain malformations such as polymic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59074db3a43375ac4b524eafd3f2682
https://doi.org/10.1007/s00381-022-05573-w

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Multilobar unilateral hypoplasia with emphasis on the posterior quadrant and severe epilepsy in children with FCD ILAE Type 1A

Autor: Roland Coras, Lily Bai, Ingmar Blümcke, Irene Wang, Samir Jabari, Peter A. Winkler, Wiebke Hofer, Tom Pieper, Manfred Kudernatsch, Till Hartlieb, Martin Staudt, Yingying Tang, Hans Holthausen, Katja Kobow

Publikováno v: Epilepsia. 63:42-60

Objective Focal cortical dysplasia (FCD) Type 1 and its three subtypes have yet not been fully characterized at the clinical, anatomopathological, and molecular level (International League Against Epilepsy [ILAE] FCD classification from 2011). We aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046aa1a8aca220d938bd5c135eef9515
https://doi.org/10.1111/epi.17114

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