Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Tom, Alber"'
Autor:
Adam R. Offenbacher, Shenshen Hu, Erin M. Poss, Cody A. M. Carr, Alexander D. Scouras, Daniil M. Prigozhin, Anthony T. Iavarone, Ali Palla, Tom Alber, James S. Fraser, Judith P. Klinman
Publikováno v:
ACS Central Science, Vol 3, Iss 6, Pp 570-579 (2017)
Externí odkaz:
https://doaj.org/article/9e694d41cae949cb94870565b513e6ae
Autor:
Jacob E. Corn, Frank DiMaio, Tom Alber, Daniil M. Prigozhin, Yue Zhang, Terrence E. O’Brien, Dean J. Tantillo, Lisa M. Prach, Justin B. Siegel
Publikováno v:
Biochemistry, vol 59, iss 47
Terpenes make up the largest class of natural products, with extensive chemical and structural diversity. Diterpenes, mostly isolated from plants and rarely prokaryotes, exhibit a variety of important biological activities and valuable applications,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d6f8982da4f2c4677d4a11206a9202
https://doi.org/10.1021/acs.biochem.0c00762
https://doi.org/10.1021/acs.biochem.0c00762
Publikováno v:
eLife, Vol 3 (2014)
Superelongation complexes (SECs) are essential for transcription elongation of many human genes, including the integrated HIV-1 genome. At the HIV-1 promoter, the viral Tat protein binds simultaneously to the nascent TAR RNA and the CycT1 subunit of
Externí odkaz:
https://doaj.org/article/41299cae61c448059c6429a27fbd39af
Autor:
Daniil M Prigozhin, Inna V Krieger, John P Huizar, Daniela Mavrici, Geoffrey S Waldo, Li-Wei Hung, James C Sacchettini, Thomas C Terwilliger, Tom Alber
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116249 (2014)
Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the
Externí odkaz:
https://doaj.org/article/1bbc03da4e664bf7ae5ff99510a4bd03
Autor:
Ursula Schulze-Gahmen, Heather Upton, Andrew Birnberg, Katherine Bao, Seemay Chou, Nevan J Krogan, Qiang Zhou, Tom Alber
Publikováno v:
eLife, Vol 2 (2013)
Human positive transcription elongation factor b (P-TEFb) phosphorylates RNA polymerase II and regulatory proteins to trigger elongation of many gene transcripts. The HIV-1 Tat protein selectively recruits P-TEFb as part of a super elongation complex
Externí odkaz:
https://doaj.org/article/a103a5737bf84775859868c0bfa4b5b2
Autor:
Michael C Chao, Karen J Kieser, Shoko Minami, Daniela Mavrici, Bree B Aldridge, Sarah M Fortune, Tom Alber, Eric J Rubin
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003197 (2013)
Peptidoglycan hydrolases are a double-edged sword. They are required for normal cell division, but when dysregulated can become autolysins lethal to bacteria. How bacteria ensure that peptidoglycan hydrolases function only in the correct spatial and
Externí odkaz:
https://doaj.org/article/30ff609cce2e49018fc57f5688d1a709
Autor:
Yue, Zhang, Lisa M, Prach, Terrence E, O'Brien, Frank, DiMaio, Daniil M, Prigozhin, Jacob E, Corn, Tom, Alber, Justin B, Siegel, Dean J, Tantillo
Publikováno v:
Biochemistry
Terpenes make up the largest class of natural products, with extensive chemical and structural diversity. Diterpenes, mostly isolated from plants and rarely prokaryotes, exhibit a variety of important biological activities and valuable applications,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa502b77a189a159f84af9257c6a7cee
https://pubmed.ncbi.nlm.nih.gov/33182997
https://pubmed.ncbi.nlm.nih.gov/33182997
Autor:
Roberta Cozzi, Daniil Prigozhin, Roberto Rosini, Francesca Abate, Matthew J Bottomley, Guido Grandi, John L Telford, C Daniela Rinaudo, Domenico Maione, Tom Alber
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49048 (2012)
Gram-positive bacteria assemble pili through class C sortase enzymes specialized in polymerizing pilin subunits into covalently linked, high-molecular-weight, elongated structures. Here we report the crystal structures of two class C sortases (SrtC1
Externí odkaz:
https://doaj.org/article/e5a5c9bd38f241e79d383985c730baf0
Autor:
Monica Totir, Nathaniel Echols, Max Nanao, Christine L Gee, Alisa Moskaleva, Scott Gradia, Anthony T Iavarone, James M Berger, Andrew P May, Chloe Zubieta, Tom Alber
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32498 (2012)
Structural biology and structural genomics projects routinely rely on recombinantly expressed proteins, but many proteins and complexes are difficult to obtain by this approach. We investigated native source proteins for high-throughput protein cryst
Externí odkaz:
https://doaj.org/article/cc3126fe522b4f69b54358fa7ed9d33c
Autor:
Andrew E Greenstein, Jason A MacGurn, Christina E Baer, Arnold M Falick, Jeffery S Cox, Tom Alber
Publikováno v:
PLoS Pathogens, Vol 3, Iss 4, p e49 (2007)
Receptor Ser/Thr protein kinases are candidates for sensors that govern developmental changes and disease processes of Mycobacterium tuberculosis (Mtb), but the functions of these kinases are not established. Here, we show that Mtb protein kinase (Pk
Externí odkaz:
https://doaj.org/article/9bd8349551f84deeb318054388395c9b