Inferring disease course from differential exon usage in the wide titinopathy spectrum.

Autor: Di Feo MF; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; Folkhälsan Research Center, Helsinki, Uusimaa, Finland., Oghabian A; Folkhälsan Research Center, Helsinki, Uusimaa, Finland., Nippala E; Folkhälsan Research Center, Helsinki, Uusimaa, Finland., Gautel M; Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, King's College London BHF Centre of Research Excellence, London, UK., Jungbluth H; Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, King's College London BHF Centre of Research Excellence, London, UK.; Paediatric Neurology, Neuromuscular Service, Evelina's Children Hospital, Guy's and St Thomas' Hospitals NHS Trust, London, UK., Forzano F; Clinical Genetics Department, Guy's and St Thomas NHS Foundation Trust, London, SE1 9RT, UK., Malfatti E; Université Paris Est Créteil, INSERM, U955, IMRB, and Reference Center for Neuromuscular Disorders, APHP Henri Mondor University Hospital, Créteil, France., Castiglioni C; Clinica MEDS, Santiago de Chile, Chile., Krey I; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, 4275, Germany., Gomez Andres D; Child Neurology Unit. Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain., Brady AF; North West Thames Regional Service, Northwick Park and St. Mark's Hospitals, Harrow, London, UK., Iascone M; Medical Genetics Laboratory, ASST Papa Giovanni XXIII, Bergamo, Italy., Cereda A; Clinical Genetics Service, Pediatria 1-ASST Papa Giovanni XXIII, Bergamo, Italy., Pezzani L; Clinical Genetics Service, Pediatria 1-ASST Papa Giovanni XXIII, Bergamo, Italy., Natera De Benito D; Neuropaediatrics Department, Hospital Sant Joan De Déu, Institut De Recerca Sant Joan De Déu, Barcelona, 08950, Spain., Nascimiento Osorio A; Neuropaediatrics Department, Hospital Sant Joan De Déu, Institut De Recerca Sant Joan De Déu, Barcelona, 08950, Spain., Estévez Arias B; Neuromuscular Unit, Department of Neurology, Hospital Sant Joan De Déu, Barcelona, Spain., Kurbatov SA; Voronezh NN Burdenko State Medical University, Voronezh, 394036, Russia.; Saratov State Medical University, Saratov, 410012, Russia., Attie-Bitach T; Unité D'embryofoetopathologie, Service D'histologie-Embryologie-Cytogénétique, Hôpital Necker-Enfants Malades, Paris, France., Nampoothiri S; Department of Pediatric Genetics, Amrita Institute of Medical Sciences & Research Centre, Kochi, Kerala, India., Ryan E; GeneDx, Gaithersburg, Maryland, USA., Morrow M; GeneDx, Gaithersburg, Maryland, USA., Gorokhova S; Marseille Medical Genetics, Aix Marseille Université, Faculté Des Sciences Médicales Et Paramédicales, Marseille, France., Chabrol B; Reference Center for Inherited Metabolic Diseases, Marseille University Hospital, Marseille, France., Sinisalo J; Helsinki University Central Hospital, Helsinki, Finland., Tolppanen H; Helsinki University Central Hospital, Helsinki, Finland., Tolva J; Transplantation Laboratory, Department of Pathology, University of Helsinki, Helsinki, Finland., Munell F; Unitat De Malalties Neuromusculars Pediàtriques, Hospital Universitari Vall D'Hebron, Barcelona, Spain., Camacho Soriano J; Histology Department, Vall D'Hebron University Hospital, Barcelona, Spain., Sanchez Duran MA; Maternal Fetal Medicine Unit, Department of Obstetrics, Universitat Autònoma de Barcelona, Hospital Vall D'Hebron, Barcelona, Spain., Johari M; Folkhälsan Research Center, Helsinki, Uusimaa, Finland.; Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, Western Australia, Australia., Tajsharghi H; Division of Biomedicine, School of Health Sciences, University of Skovde, Skovde, Sweden., Hackman P; Folkhälsan Research Center, Helsinki, Uusimaa, Finland., Udd B; Folkhälsan Research Center, Helsinki, Uusimaa, Finland.; Department of Musculoskeletal Diseases, Tampere University Hospital, Tampere, Pirkanmaa, Finland., Savarese M; Folkhälsan Research Center, Helsinki, Uusimaa, Finland.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 Oct; Vol. 11 (10), pp. 2745-2755. Date of Electronic Publication: 2024 Aug 28.

Amiodarone accumulates two cholesterol precursors in myocardium: A controlled clinical study.

Autor: Simonen P; Heart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Lommi J; Heart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Lemström K; Heart and Lung Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Tolva J; Transplantation Laboratory, Department of Pathology, University of Helsinki, Helsinki, Finland., Sinisalo J; Heart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Gylling H; Heart and Lung Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Publikováno v: Journal of internal medicine [J Intern Med] 2023 Oct; Vol. 294 (4), pp. 506-514. Date of Electronic Publication: 2023 Jul 06.

Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure.

Autor: Wang H; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland., Segersvärd H; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland., Siren J; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland., Perttunen S; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland., Immonen K; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland., Kosonen R; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland., Chen YC; Zebrafish Unit, HiLIFE and Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland., Tolva J; Transplantation Laboratory, Department of Pathology, University of Helsinki, 00014 Helsinki, Finland., Laivuori M; Department of Vascular Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, 00014 Helsinki, Finland., Mäyränpää MI; Department of Pathology, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland., Kovanen PT; Atherosclerosis Research Laboratory, Wihuri Research Institute, 00290 Helsinki, Finland., Sinisalo J; Heart and Lung Center, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland., Laine M; Heart and Lung Center, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland., Tikkanen I; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland., Lakkisto P; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland.; Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 02; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 02.

Osteoid Metaplasia in Femoral Artery Plaques Is Associated With the Clinical Severity of Lower Extremity Artery Disease in Men.

Autor: Laivuori M; Department of Vascular Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Tolva J; Transplantation Laboratory, Department of Pathology, University of Helsinki, Helsinki, Finland., Lokki AI; Transplantation Laboratory, Department of Pathology, University of Helsinki, Helsinki, Finland.; Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland., Linder N; Institute for Molecular Medicine Finland, HILIFE, University of Helsinki, Helsinki, Finland., Lundin J; Institute for Molecular Medicine Finland, HILIFE, University of Helsinki, Helsinki, Finland.; Department of Global Public Health, Global Health/IHCAR, Karolinska Institutet, Stockholm, Sweden., Paakkanen R; Transplantation Laboratory, Department of Pathology, University of Helsinki, Helsinki, Finland.; Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Albäck A; Department of Vascular Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Venermo M; Department of Vascular Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Mäyränpää MI; Department of Pathology, HUSLAB, Meilahti Central Laboratory of Pathology, University of Helsinki, Helsinki, Finland., Lokki ML; Transplantation Laboratory, Department of Pathology, University of Helsinki, Helsinki, Finland., Sinisalo J; Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2020 Dec 10; Vol. 7, pp. 594192. Date of Electronic Publication: 2020 Dec 10 (Print Publication: 2020).

Soluble HLA-DR serum levels are associated with smoking but not with acute coronary syndrome.

Autor: Tolva J; Transplantation Laboratory, University of Helsinki, Helsinki, Finland. Electronic address: johanna.m.tolva@gmail.com., Paakkanen R; Transplantation Laboratory, University of Helsinki, Helsinki, Finland; HUH Heart and Lung Center, Division of Cardiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Jarva H; Department of Bacteriology and Immunology and Research Programs Unit, University of Helsinki, and HUSLAB, Helsinki, Finland., Pussinen P; Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Havulinna AS; National Institute for Health and Welfare, Helsinki, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Sinisalo J; HUH Heart and Lung Center, Division of Cardiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Lokki ML; Transplantation Laboratory, University of Helsinki, Helsinki, Finland.

Publikováno v: Atherosclerosis [Atherosclerosis] 2017 Nov; Vol. 266, pp. 58-63. Date of Electronic Publication: 2017 Sep 21.