Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Autor: Clayton, Emma L., Mancuso, Renzo, Tolstrup Nielsen, Troels, Mizielinska, Sarah, Holmes, Holly, Powell, Nicholas, Norona, Frances, Overgaard Larsen, Jytte, Milioto, Carmelo, Wilson, Katherine M., Lythgoe, Mark F., Ourselin, Sebastian, Nielsen, Jörgen E., Johannsen, Peter, Holm, Ida, Collinge, John, Oliver, Peter L., Gomez-Nicola, Diego, Isaacs, Adrian M., Gade, Anders, Englund, Elisabet, Fisher, Elizabeth, Brown, Jeremy, Stockholm, Jette, Roos, Peter, Gydesen, Susanne, Lindquist, Suzanne, Thusgaard, Tove

Publikováno v: Clayton, E L, Mancuso, R, Tolstrup Nielsen, T, Mizielinska, S, Holmes, H, Powell, N, Norona, F, Overgaard Larsen, J, Milioto, C, Wilson, K M, Lythgoe, M F, Ourselin, S, Nielsen, J E, Johannsen, P, Holm, I, Collinge, J, Oliver, P L, Gomez-Nicola, D, Isaacs, A M, Gade, A, Englund, E, Fisher, E, Brown, J, Stockholm, J, Roos, P, Gydesen, S & Lindquist, S & Thusgaard, T 2017, ' Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation ', Human Molecular Genetics, vol. 26, no. 5, ddx003, pp. 873-887 . https://doi.org/10.1093/hmg/ddx003

Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset brain volume loss ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::a2506fd546a068927470a7ca9de1ceea
https://kclpure.kcl.ac.uk/en/publications/f98319eb-b042-47ad-9b58-219ea66de6fa