Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Tolrestat"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Elham Tavanai, Fahimeh Hajiabolhassan
Publikováno v:
European Archives of Oto-Rhino-Laryngology. 278:3653-3665
Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, which, over time, lead to major chronic complications in various organs of the body. A growing body of research suggests that diabetes could also result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3973fc61e36f1df8e16e5be65b46104d
https://doi.org/10.1007/s00405-021-06630-x
https://doi.org/10.1007/s00405-021-06630-x
Structural Basis for the High all-trans-Retinaldehyde Reductase Activity of the Tumor Marker AKR1B10
Autor:
Gallego, Oriol, Ruiz, F. Xavier, Ardèvol, Albert, Domínguez, Marta, Alvarez, Rosana, de Lera, Angel R., Rovira, Carme, Farrés, Jaume, Fita, Ignacio, Parés, Xavier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2007 Dec . 104(52), 20764-20769.
Externí odkaz:
https://www.jstor.org/stable/25450975
Autor:
Yasuhide Sasajima, Yoshifumi Morikawa, Satoshi Endo, Toshiyuki Matsunaga, Koichi Suenami, Kiyohito Sato, Kyoko Kamase, Hidetoshi Miyazono, Akira Ikari, Yuji Takekoshi, Yasunari Monguchi
Publikováno v:
Neurotoxicity research. 39(4)
Chronic exposure to cathinone derivatives increases the risk of severe health hazards, whereas little is known about the detailed pathogenic mechanisms triggered by the derivatives. We have recently shown that treatment with α-pyrrolidinononanopheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f76b7910d5d039a659da200ea07b8df
https://pubmed.ncbi.nlm.nih.gov/34043181
https://pubmed.ncbi.nlm.nih.gov/34043181
Publikováno v:
Current drug metabolism. 21(14)
Background: Aldol reductase (AR) is the polyol pathway's main enzyme that portrays a crucial part in developing ‘complications of diabetes’ involving cataract, retinopathy, nephropathy, and neuropathy. These diabetic abnormalities are triggered t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d8d9953d6e75520ada93cee37cc10d
https://pubmed.ncbi.nlm.nih.gov/33069193
https://pubmed.ncbi.nlm.nih.gov/33069193
Autor:
Zhenzhen Min, Zhiguo Wang, Wanrong Tang, Xin Zhang, Chao Wang, Jiejie Shen, Chenyun Zhang, Xuemeng Liu, Xiaoling Xu, Dan Liu
Publikováno v:
FEBS lettersReferences. 594(3)
Tolrestat and epalrestat have been characterized as noncompetitive inhibitors of aldo-ketone reductase 1B1 (AKR1B1), a leading drug target for the treatment of type 2 diabetes complications. However, clinical applications are limited for most AKR1B1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219b59bf7bc3ec1e7ae7a0825d49020b
https://pubmed.ncbi.nlm.nih.gov/31573681
https://pubmed.ncbi.nlm.nih.gov/31573681
Autor:
Arpita Devi
Publikováno v:
Current computer-aided drug design. 16(6)
Background: Cancer is a well-known and well-studied disease. There are environmental as well as genetic factors that trigger cancer. All forms of cancer are associated with the deregulation of genes and proteins. Aldose reductase, Aldose Reductase li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639ff7c83ada32155b5a2e6c246c4199
https://pubmed.ncbi.nlm.nih.gov/31749429
https://pubmed.ncbi.nlm.nih.gov/31749429
Autor:
Viney Lather, Ajmer Singh Grewal, Bhupinder Singh Sekhon, Shashikant Bhardwaj, Deepti Pandita
Publikováno v:
Scopus-Elsevier
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often accompanied by several long-term complications, namely neuropathy, nephropathy, retinopathy, cataract, and cardiovascular. Aldose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cbc5ad2296fa939bbc270bff5376cc
https://doi.org/10.2174/1389557515666150909143737
https://doi.org/10.2174/1389557515666150909143737
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.