Zobrazeno 1 - 10 of 384 pro vyhledávání: '"Tolosa, L."'
1
Akademický článek
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3
A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action
Autor: Escher SE, Aguayo-Orozco A, Benfenati E, Bitsch A, Braunbeck T, Brotzmann K, Bois F, van der Burg B, Castel J, Exner T, Gadaleta D, Gardner I, Goldmann D, Hatley O, Golbamaki N, Graepel R, Jennings P, Limonciel A, Long A, Maclennan R, Mombelli E, Norinder U, Jain S, Capinha LS, Taboureau OT, Tolosa L, Vrijenhoek NG, van Vugt-Lussenburg BMA, Walker P, van de Water B, Wehr M, White A, Zdrazil B, Fisher C
Publikováno v: TOXICOLOGY IN VITRO
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
This read-across case study characterises thirteen, structurally similar carboxylic acids demonstrating the application of in vitro and in silico human-based new approach methods, to determine biological similarity. Based on data from in vivo animal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::8c5dd590086ef2c34763ed7dac442b62
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15208
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4
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes
Autor: Moreno-Torres M, Kumar M, García-Llorens G, Quintás G, Tricot T, Boon R, Tolosa L, Toprakhisar B, Chesnais F, Verfaillie C, Castell JV
Publikováno v: JOURNAL OF PROTEOME RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Typical protocols to differentiate induced pluripotent stem cells (iPSCs) from hepatocyte-like cells (HLCs) imply complex strategies that include transfection with key hepatic transcription factors and the addition to culture media of nutrients, grow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::9a76b4ad50d7525022c71a4ee84fb918
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15446
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6
Akademický článek
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8
Cell Models and Omics Techniques for the Study of Nonalcoholic Fatty Liver Disease: Focusing on Stem Cell-Derived Cell Models
Autor: Pelechá M, Villanueva-Bádenas E, Timor-López E, Donato MT, Tolosa L
Publikováno v: Antioxidants (Basel, Switzerland)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in western countries. The molecular mechanisms leading to NAFLD are only partially understood, and effective therapeutic interventions are clearly needed. Ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::51d2787f64c3522809987854a6df23eb
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15360
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9
High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells
Autor: Donato M, Tolosa L
Publikováno v: Antioxidants (Basel, Switzerland)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Drug-induced liver injury (DILI) remains a major cause of drug development failure, post-marketing warnings and restriction of use. An improved understanding of the mechanisms underlying DILI is required for better drug design and development. Enhanc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::24380cdc4a9c08c57e53f61c2785ca6a
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13625
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10
Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology
Autor: Donato MT, Tolosa L
Publikováno v: FOOD AND CHEMICAL TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Safety evaluation of thousands of chemicals that are directly added to or come in contact with food is needed. Due to the central role of the liver in intermediary and energy metabolism and in the biotransformation of foreign compounds, the hepatotox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::32293f5cbe0c4fe9f5aee12135583f52
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13558
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