Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Toloo Taghian"'
Autor:
Hector Ribeiro Benatti, Rachel D. Prestigiacomo, Toloo Taghian, Rachael Miller, Robert King, Matthew J. Gounis, Ugur Celik, Stephanie Bertrand, Susan Tuominen, Lindsey Bierfeldt, Elizabeth Parsley, Jillian Gallagher, Erin F. Hall, Abigail W. McElroy, Miguel Sena-Esteves, Anastasia Khvorova, Neil Aronin, Heather L. Gray-Edwards
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101122- (2023)
Oligonucleotide therapeutics offer great promise in the treatment of previously untreatable neurodegenerative disorders; however, there are some challenges to overcome in pre-clinical studies. (1) They carry a well-established dose-related acute neur
Externí odkaz:
https://doaj.org/article/47746a402a8d49c9b29336720b82daae
Autor:
Toloo Taghian, Ana Rita Batista, Sarah Kamper, Michael Caldwell, Laura Lilley, Hao Li, Paola Rodriguez, Katerina Mesa, Shaokuan Zheng, Robert M. King, Matthew J. Gounis, Sophia Todeasa, Anne Maguire, Douglas R. Martin, Miguel Sena-Esteves, Thomas J. Meade, Heather L. Gray-Edwards
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 128-134 (2021)
Transformative results of adeno-associated virus (AAV) gene therapy in patients with spinal muscular atrophy and Leber’s congenital amaurosis led to approval of the first two AAV products in the United States to treat these diseases. These extraord
Externí odkaz:
https://doaj.org/article/c16bf88485644845ad32d3c283989ad8
Autor:
Chantal M. Ferguson, Bruno M.D.C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew Hassler, Dimas Echeverria, James W. Gilbert, Emily G. Knox, Jillian Caiazzi, Reka A. Haraszti, Robert M. King, Toloo Taghian, Ajit Puri, Richard P. Moser, Matthew J. Gounis, Neil Aronin, Heather Gray-Edwards, Anastasia Khvorova
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs (di-siRNAs), which support robust and long-term efficacy in rodent and nonhuman primate brains
Externí odkaz:
https://doaj.org/article/6446b294c4ec4d69983aef3f4ec8e137
Autor:
Brett D. Story, Matthew E. Miller, Allison M. Bradbury, Emily D. Million, Dongsheng Duan, Toloo Taghian, Dominik Faissler, Deborah Fernau, Sidney J. Beecy, Heather L. Gray-Edwards
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally oc
Externí odkaz:
https://doaj.org/article/e95df927e9164cefbe9d29cd9a8a6d7c
Autor:
Abdul Q Sheikh, Jennifer R Hurley, Wei Huang, Toloo Taghian, Andrei Kogan, Hongkwan Cho, Yigang Wang, Daria A Narmoneva
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36840 (2012)
Diabetic cardiomyopathy (DCM) is a diabetic complication, which results in myocardial dysfunction independent of other etiological factors. Abnormal intracellular calcium ([Ca(2+)](i)) homeostasis has been implicated in DCM and may precede clinical m
Externí odkaz:
https://doaj.org/article/b1df6052fb4446c88a61bed77e0fd405
Autor:
Laura M. Lilley, Sarah G. Kamper, Thomas J. Meade, Ana Rita Batista, Miguel Sena-Esteves, Hao Li, Matthew J. Gounis, Douglas R. Martin, Shaokuan Zheng, Katerina Mesa, Robert M. King, Paola Rodriguez, Toloo Taghian, Heather L. Gray-Edwards, Michael A. Caldwell, Anne S Maguire, Sophia H. Todeasa
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 128-134 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Transformative results of adeno-associated virus (AAV) gene therapy in patients with spinal muscular atrophy and Leber’s congenital amaurosis led to approval of the first two AAV products in the United States to treat these diseases. These extraord
Autor:
Toloo Taghian, Jillian Gallagher, Erin Batcho, Caitlin Pullan, Tim Kuchel, Thomas Denney, Raj Perumal, Shamika Moore, Robb Muirhead, Paul Herde, Daniel Johns, Chris Christou, Amanda Taylor, Thomas Passler, Sanjana Pulaparthi, Erin Hall, Sundeep Chandra, Charles A. O’Neill, Heather Gray-Edwards
Publikováno v:
Journal of Huntington's disease. 11(4)
Background: Huntington’s disease (HD) is a fatal neurodegenerative autosomal dominant disorder with prevalence of 1 : 20000 that has no effective treatment to date. Translatability of candidate therapeutics could be enhanced by additional testing i
Autor:
Stephanie G Bertrand, Mohammed Salman Shazeeb, Erin Horn, Deborah Fernau, Miguel Sena-Esteves, Toloo Taghian, Lindsey J Bierfeldt, Aly Abayazeed, Oguz Cataltepe, Stephen Frey, Susan M Tuominen, Jennifer W. Koehler, Heather L. Gray-Edwards, Terence R. Flotte, Matthew J. Gounis
Publikováno v:
Human Gene Therapy. 31:617-625
Thalamic infusion of adeno-associated viral (AAV) vectors has been shown to have therapeutic effects in neuronopathic lysosomal storage diseases. Preclinical studies in sheep model of Tay-Sachs disease demonstrated that bilateral thalamic injections
Publikováno v:
FASEB J
Early pro-inflammatory signaling in the endocrine pancreas involves activation of NF-κB, which is believed to be important for determining the ultimate fate of β−cells and hence progression of Type 1 diabetes (T1D). Thus, early non-invasive detec
Autor:
Priya Kumthekar, Hector Benatti, Toloo Taghian, William B Gormley, Seema Nagpal, William C Baker, Rajan Patel, Emma Brown, Marcie Glicksman, Heather Gray-Edwards
Publikováno v:
Neuro-Oncology. 24:vii94-vii94
Background Appropriate drug distribution is needed for effective treatment of brain metastases and leptomeningeal carcinomatosis. Lack of proper drug bioavailability in the CNS contributes to the poor outcome in these patients. EnClear Therapies has