Discovery of a Potent, Orally Bioavailable β3 Adrenergic Receptor Agonist, (R)-N-[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Autor: Lawrence F. Colwell, William P. Feeney, Liping Deng, Michael J. Forrest, Randy R. Miller, Ralph A. Stearns, Ann E. Weber, Mari R. Candelore, Gary J Hom, D. E. Macintyre, Mathew J. Wyvratt, Dawn Chitty, Robert J. Mathvink, Tolman Js, Laurie Tota, Margaret A. Cascieri, M. H. Fisher

Publikováno v: Journal of Medicinal Chemistry. 43:3832-3836

As part of our investigation into the development of orally bioavailable beta(3) adrenergic receptor agonists, we have identified a series of pyridylethanolamine analogues possessing a substituted thiazole benzenesulfonamide pharmacophore that are po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac50fd493c10b70259b4e092537228b
https://doi.org/10.1021/jm000286i

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Global changes in gene expression by the opportunistic pathogen Burkholderia cenocepacia in response to internalization by murine macrophages.

Autor: Tolman JS; Infectious Diseases Research Group, Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, N6A 5C1, Canada., Valvano MA

Publikováno v: BMC genomics [BMC Genomics] 2012 Feb 09; Vol. 13, pp. 63. Date of Electronic Publication: 2012 Feb 09.