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An engineered cereblon optimized for high throughput screening and molecular glue discovery.

Autor: Bailey HJ; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main and Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany; Max Planck Institute of Biophysics, Max-von-Laue-Strasse 3, 60439 Frankfurt am Main, Germany., Eisert J; Merck Healthcare KGaA, Discovery and Development Technologies, Frankfurter Straße 250, 64293 Darmstadt, Germany., Kazi R; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main and Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany., Gerhartz J; Institute of Structural Biology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany., Pieńkowska DE; Institute of Structural Biology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany., Dressel I; Institute of Structural Biology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany., Vollrath J; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main and Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany; Max Planck Institute of Biophysics, IMPRS on Cellular Biophysics, Max-von-Laue-Strasse 3, 60439 Frankfurt am Main, Germany; Max Planck Institute of Biophysics, Max-von-Laue-Strasse 3, 60439 Frankfurt am Main, Germany., Kondratov I; Enamine Ltd., Winston Churchill Street 78, 02094 Kyiv, Ukraine; Enamine Germany GmbH, Industriepark Hoechst, G837, 65926 Frankfurt am Main, Germany; V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Akademik Kukhar Street 1, 02094 Kyiv, Ukraine., Matviyuk T; Enamine Ltd., Winston Churchill Street 78, 02094 Kyiv, Ukraine., Tolmachova N; Enamine Ltd., Winston Churchill Street 78, 02094 Kyiv, Ukraine., Shah VJ; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main and Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany., Giuliani G; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main and Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany., Mosler T; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main and Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany., Geiger TM; Institute of Structural Biology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany., Esteves AM; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal., Santos SP; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal., Sousa RL; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal., Bandeiras TM; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal., Leibrock EM; Merck Healthcare KGaA, Discovery and Development Technologies, Frankfurter Straße 250, 64293 Darmstadt, Germany., Bauer U; Merck Healthcare KGaA, Discovery and Development Technologies, Frankfurter Straße 250, 64293 Darmstadt, Germany., Leuthner B; Merck Healthcare KGaA, Discovery and Development Technologies, Frankfurter Straße 250, 64293 Darmstadt, Germany., Langer JD; Max Planck Institute of Biophysics, Max-von-Laue-Strasse 3, 60439 Frankfurt am Main, Germany; Max Planck Institute for Brain Research, Max-von-Laue-Strasse 4, 60439 Frankfurt am Main, Germany., Wegener AA; Merck Healthcare KGaA, Discovery and Development Technologies, Frankfurter Straße 250, 64293 Darmstadt, Germany., Nowak RP; Institute of Structural Biology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany., Sorrell FJ; Merck Healthcare KGaA, Discovery and Development Technologies, Frankfurter Straße 250, 64293 Darmstadt, Germany. Electronic address: fiona.sorrell@merckgroup.com., Dikic I; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main and Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany; Max Planck Institute of Biophysics, Max-von-Laue-Strasse 3, 60439 Frankfurt am Main, Germany. Electronic address: dikic@biochem2.uni-frankfurt.de.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.