Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

Autor: Ernest Y. Lee, Mandy Hung, Michel Gilliet, Changsheng Zhang, Veronica Veksler, Jeremy Di Domizio, Fan Jin, Will Connell, Pengyu Ren, Gerard C. L. Wong, Nicolas Malkoff

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012

Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune

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https://escholarship.org/uc/item/0388t0qm