Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Autor: Rozman, Jan, Rathkolb, Birgit, Meehan, Terrence F, Codner, Gemma F, Fiegel, Tanja, Ring, Natalie, Westerberg, Henrik, Greenaway, Simon, Sneddon, Duncan, Morgan, Hugh, Loeffler, Jorik, Stewart, Michelle E, Ramirez-Solis, Ramiro, Mason, Jeremy, Bradley, Allan, Skarnes, William C, Steel, Karen P, Maguire, Simon A, Dench, Joshua, Lafont, David, Vancollie, Valerie E, Pearson, Selina A, Gates, Amy S, Sanderson, Mark, Haselimashhadi, Hamed, Shannon, Carl, Anthony, Lauren F E, Sumowski, Maksymilian T, McLaren, Robbie S B, Doe, Brendan, Wardle-Jones, Hannah, Griffiths, Mark N D, Galli, Antonella, Swiatkowska, Agnieszka, Isherwood, Christopher M, Consortium, IMPC, Speak, Anneliese O, Cambridge, Emma L, Wilson, Heather M, Caetano, Susana S, Maguire, Anna Karin B, Adams, David J, Bottomley, Joanna, Ryder, Ed, Gleeson, Diane, Pouilly, Laurent, Hough, Tertius, Rousseau, Stephane, Auburtin, Aurélie, Reilly, Patrick, Ayadi, Abdel, Selloum, Mohammed, Wood, Joshua A, Clary, Dave, Havel, Peter, Tolentino, Todd, Tolentino, Heather, Mallon, Ann-Marie, Schuchbauer, Mike, Pedroia, Sheryl, Trainor, Amanda, Djan, Esi, Pham, Milton, Huynh, Alison, De Vera, Vincent, Seavitt, John, Gallegos, Juan, Garza, Arturo, Wells, Sara, Mangin, Elise, Senderstrom, Joel, Lazo, Iride, Mowrey, Kate, Bohat, Ritu, Samaco, Rodney, Veeraragavan, Surabi, Beeton, Christine, Kalaga, Sowmya, Kelsey, Lois, Santos, Luis, Vukobradovic, Igor, Berberovic, Zorana, Owen, Celeste, Qu, Dawei, Guo, Ruolin, Newbigging, Susan, Morikawa, Lily, Law, Napoleon, Shang, Xueyuan, Feugas, Patricia, Lelliott, Christopher J, Wang, Yanchun, Eskandarian, Mohammad, Zhu, Yingchun, Penton, Patricia, Laurin, Valerie, Clarke, Shannon, Lan, Qing, Sleep, Gillian, Creighton, Amie, Jacob, Elsa, White, Jacqueline K, Danisment, Ozge, Gertsenstein, Marina, Pereira, Monica, MacMaster, Suzanne, Tondat, Sandra, Carroll, Tracy, Cabezas, Jorge, Hunter, Jane, Clark, Greg, Bubshait, Mohammed, Oestereicher, Manuela A, Sorg, Tania, Miller, David, Sohel, Khondoker, Adissu, Hibret, Ganguly, Milan, Bezginov, Alexandr, Chiani, Francesco, Di Pietro, Chiara, Di Segni, Gianfranco, Ermakova, Olga, Ferrara, Filomena, Champy, Marie-France, Fruscoloni, Paolo, Gambadoro, Aalessia, Gastaldi, Serena, Golini, Elisabetta, La Sala, Gina, Mandillo, Silvia, Marazziti, Daniela, Massimi, Marzia, Matteoni, Rafaele, Orsini, Tiziana, Bower, Lynette R, Pasquini, Miriam, Raspa, Marcello, Rauch, Aline, Rossi, Gianfranco, Rossi, Nicoletta, Putti, Sabrina, Scavizzi, Ferdinando, Tocchini-Valentini, Giuseppe D, Wakana, Shigeharu, Suzuki, Tomohiro, Reynolds, Corey L, Tamura, Masaru, Kaneda, Hideki, Furuse, Tamio, Kobayashi, Kimio, Miura, Ikuo, Yamada, Ikuko, Obata, Yuichi, Yoshiki, Atsushi, Ayabe, Shinya, Chambers, J Nicole, Flenniken, Ann M, Chalupsky, Karel, Seisenberger, Claudia, Bürger, Antje, Beig, Joachim, Kühn, Ralf, Hörlein, Andreas, Schick, Joel, Oritz, Oskar, Giesert, Florian, Graw, Jochen, Murray, Stephen A, Ollert, Markus, Schmidt-Weber, Carsten, Stoeger, Tobias, Önder Yildirim, Ali, Eickelberg, Oliver, Klopstock, Thomas, Busch, Dirk H, Bekeredjian, Raffi, Zimmer, Andreas, Jacobsen, Jules O, Nutter, Lauryl M J, Smedley, Damian, Dickinson, Mary E, Benso, Frank, Morse, Iva, Kim, Hyoung-Chin, Lee, Ho, Cho, Soo Young, Svenson, Karen L, West, David, Tocchini-Valentini, Glauco P, Schütt, Christine, Beaudet, Arthur L, Bosch, Fatima, Braun, Robert B, Dobbie, Michael S, Gao, Xiang, Herault, Yann, Moshiri, Ala, Moore, Bret A, Kent Lloyd, K. C., McKerlie, Colin, Ravindranath, Aakash Chavan, Masuya, Hiroshi, Tanaka, Nobuhiko, Flicek, Paul, Parkinson, Helen E, Sedlacek, Radislav, Seong, Je Kyung, Wang, Chi-Kuang Leo, Moore, Mark, Brown, Steve D, Tschöp, Matthias H, Leuchtenberger, Stefanie, Wurst, Wolfgang, Klingenspor, Martin, Wolf, Eckhard, Beckers, Johannes, Machicao, Fausto, Peter, Andreas, Staiger, Harald, Häring, Hans-Ulrich, Grallert, Harald, Campillos, Monica, Sharma, Sapna, Maier, Holger, Fuchs, Helmut, Gailus-Durner, Valerie, Werner, Thomas, Hrabe de Angelis, Martin, Aguilar-Pimentel, Antonio, Becker, Lore, Treise, Irina, Moreth, Kristin, Garrett, Lillian, Kistler, Martin, Hölter, Sabine M, Zimprich, Annemarie, Marschall, Susan, Amarie, Oana V, Calzada-Wack, Julia, Neff, Frauke, Brachthäuser, Laura, Lengger, Christoph, Stoeger, Claudia, Zapf, Lilly, Willershäuser, Monja, Cho, Yi-Li, da Silva-Buttkus, Patricia, Kraiger, Markus J, Mayer-Kuckuk, Philipp, Gampe, Karen Kristine, Wu, Moya, Conte, Nathalie, Warren, Jonathan, Chen, Chao-Kung, Tudose, Ilinca, Brommage, Robert, Relac, Mike, Matthews, Peter, Cater, Heather L, Natukunda, Helen P, Cleak, James, Teboul, Lydia M, Clementson-Mobbs, Sharon, Szoke-Kovacs, Zsombor, Walling, Alison P, Johnson, Sara J

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature communications, vol 9, iss 1
Rozman, J, Rathkolb, B, Oestereicher, M A, Schütt, C, Ravindranath, A C, Leuchtenberger, S, Sharma, S, Kistler, M, Willershäuser, M, Brommage, R, Meehan, T F, Mason, J, Haselimashhadi, H, Aguilar-Pimentel, A, Becker, L, Treise, I, Moreth, K, Garrett, L, Hölter, S M, Zimprich, A, Marschall, S, Amarie, O V, Calzada-Wack, J, Neff, F, Brachthäuser, L, Lengger, C, Stoeger, C, Zapf, L, Cho, Y L, Da Silva-Buttkus, P, Kraiger, M J, Mayer-Kuckuk, P, Gampe, K K, Wu, M, Conte, N, Warren, J, Chen, C K, Tudose, I, Relac, M, Matthews, P, Cater, H L, Natukunda, H P, Cleak, J, Teboul, L M, Clementson-Mobbs, S, Szoke-Kovacs, Z, Walling, A P, Johnson, S J, Codner, G F, Fiegel, T, Ring, N, Westerberg, H, Greenaway, S, Sneddon, D, Morgan, H, Loeffler, J, Stewart, M E, Ramirez-Solis, R, Bradley, A, Skarnes, W C, Steel, K P, Maguire, S A, Dench, J, Lafont, D, Vancollie, V E, Pearson, S A, Gates, A S, Sanderson, M, Shannon, C, Anthony, L F E, Sumowski, M T, McLaren, R S B, Doe, B, Wardle-Jones, H, Griffiths, M N D, Galli, A, Swiatkowska, A, Isherwood, C M, Speak, A O, Cambridge, E L, Wilson, H M, Caetano, S S, Maguire, A K B, Adams, D J, Bottomley, J, Ryder, E, Gleeson, D, Pouilly, L, Rousseau, S, Auburtin, A, Reilly, P, Ayadi, A, Selloum, M, Wood, J A, Clary, D, Havel, P, Tolentino, T, Tolentino, H, Schuchbauer, M, Pedroia, S, Trainor, A, Djan, E, Pham, M, Huynh, A, De Vera, V, Seavitt, J, Gallegos, J, Garza, A, Mangin, E, Senderstrom, J, Lazo, I, Mowrey, K, Bohat, R, Samaco, R, Veeraragavan, S, Beeton, C, Kalaga, S, Kelsey, L, Vukobradovic, I, Berberovic, Z, Owen, C, Qu, D, Guo, R, Newbigging, S, Morikawa, L, Law, N, Shang, X, Feugas, P, Wang, Y, Eskandarian, M, Zhu, Y, Penton, P, Laurin, V, Clarke, S, Lan, Q, Sleep, G, Creighton, A, Jacob, E, Danisment, O, Gertsenstein, M, Pereira, M, MacMaster, S, Tondat, S, Carroll, T, Cabezas, J, Hunter, J, Clark, G, Bubshait, M, Miller, D, Sohel, K, Adissu, H, Ganguly, M, Bezginov, A, Chiani, F, Di Pietro, C, Di Segni, G, Ermakova, O, Ferrara, F, Fruscoloni, P, Gambadoro, A, Gastaldi, S, Golini, E, La Sala, G, Mandillo, S, Marazziti, D, Massimi, M, Matteoni, R, Orsini, T, Pasquini, M, Raspa, M, Rauch, A, Rossi, G, Rossi, N, Putti, S, Scavizzi, F, Tocchini-Valentini, G D, Wakana, S, Suzuki, T, Tamura, M, Kaneda, H, Furuse, T, Kobayashi, K, Miura, I, Yamada, I, Obata, Y, Yoshiki, A, Ayabe, S, Chambers, J N, Chalupsky, K, Seisenberger, C, Bürger, A, Beig, J, Kühn, R, Hörlein, A, Schick, J, Oritz, O, Giesert, F, Graw, J, Ollert, M, Schmidt-Weber, C, Stoeger, T, Önder Yildirim, A, Eickelberg, O, Klopstock, T, Busch, D H, Bekeredjian, R, Zimmer, A, Jacobsen, J O, Smedley, D, Dickinson, M E, Benso, F, Morse, I, Kim, H C, Lee, H, Cho, S Y, Hough, T, Mallon, A M, Wells, S, Santos, L, Lelliott, C J, White, J K, Sorg, T, Champy, M F, Bower, L R, Reynolds, C L, Flenniken, A M, Murray, S A, Nutter, L M J, Svenson, K L, West, D, Tocchini-Valentini, G P, Beaudet, A L, Bosch, F, Braun, R B, Dobbie, M S, Gao, X, Herault, Y, Moshiri, A, Moore, B A, Kent Lloyd, K C, McKerlie, C, Masuya, H, Tanaka, N, Flicek, P, Parkinson, H E, Sedlacek, R, Seong, J K, Wang, C K L, Moore, M, Brown, S D, Tschöp, M H, Wurst, W, Klingenspor, M, Wolf, E, Beckers, J, MacHicao, F, Peter, A, Staiger, H, Häring, H U, Grallert, H, Campillos, M, Maier, H, Fuchs, H, Gailus-Durner, V, Werner, T & De Angelis, M H 2018, ' Identification of genetic elements in metabolism by high-throughput mouse phenotyping ', Nature Communications, vol. 9, 288 . https://doi.org/10.1038/s41467-017-01995-2
Nature Communications 9(1), 288 (2018). doi:10.1038/s41467-017-01995-2
Nat. Commun. 9:288 (2018)

Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b0e532914292040e57c2e66d31b14e
http://europepmc.org/articles/PMC5773596