Cognitive training and neuroplasticity in mild cognitive impairment (COG-IT): protocol for a two-site, blinded, randomised, controlled treatment trial

Autor: D'Antonio, Jessica, Simon-Pearson, Laura, Goldberg, Terry E., Sneed, Joel R., Rushia, Sara, Kerner, Nancy Allison, Andrews, Howard F., Hellegers, Caroline, Tolbert, Sierra, Perea, Elena, Petrella, Jeffrey, Doraiswamy, P. Murali, Devanand, Devangere P.

Introduction: Mild cognitive impairment (MCI) is common in older adults and represents a high-risk group for progression to Alzheimer's disease (AD). Medication trials in MCI have generally failed, but new discoveries with brain plasticity in ageing

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Cognitive training and neuroplasticity in mild cognitive impairment (COG-IT): protocol for a two-site, blinded, randomised, controlled treatment trial.

Autor: D'Antonio J; Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, New York, USA., Simon-Pearson L; Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, New York, USA., Goldberg T; Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, New York, USA.; Department of Psychiatry, Columbia University Medical Center, New York, New York, USA., Sneed JR; Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, New York, USA.; Department of Psychology, Queens College, City University of New York, Flushing, New York, USA., Rushia S; Department of Psychology, Queens College, City University of New York, Flushing, New York, USA.; Department of Psychology, The Graduate Center, City University of New York, New York, New York, USA., Kerner N; Department of Psychiatry, Columbia University Medical Center, New York, New York, USA., Andrews H; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA., Hellegers C; Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA., Tolbert S; Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA., Perea E; Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA., Petrella J; Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA., Doraiswamy PM; Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA., Devanand D; Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, New York, USA dpd3@cumc.columbia.edu.; Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.

Publikováno v: BMJ open [BMJ Open] 2019 Aug 30; Vol. 9 (8), pp. e028536. Date of Electronic Publication: 2019 Aug 30.