Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tokuwa Kanno"'
Autor:
Jocelyn M. Choo, Alyce M. Martin, Steven L. Taylor, Emily Sun, Fredrick M. Mobegi, Tokuwa Kanno, Alyson Richard, Lucy D. Burr, Stevie Lingman, Megan Martin, Damien J. Keating, A. James Mason, Geraint B. Rogers
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Long-term low-dose macrolide therapy is now widely used in the treatment of chronic respiratory diseases for its immune-modulating effects, although the antimicrobial properties of macrolides can also have collateral impacts on the gut micro
Externí odkaz:
https://doaj.org/article/8d63491e09574059afe8fa5c75bca7a8
Autor:
Salvina Laura Tammaccaro, Philippe Prigent, Jean-Christophe Le Bail, Odette Dos-Santos, Laurent Dassencourt, Myriam Eskandar, Armelle Buzy, Olivier Venier, Jean-Claude Guillemot, Yaligara Veeranagouda, Michel Didier, Emmanuel Spanakis, Tokuwa Kanno, Matteo Cesaroni, Stephane Mathieu, Luc Canard, Alhassan Casse, Fanny Windenberger, Loreley Calvet, Laurence Noblet, Sukhvinder Sidhu, Laurent Debussche, Jurgen Moll, Iris Valtingojer
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 553 (2023)
KRASG12C is one of the most common mutations detected in non-small cell lung cancer (NSCLC) patients, and it is a marker of poor prognosis. The first FDA-approved KRASG12C inhibitors, sotorasib and adagrasib, have been an enormous breakthrough for pa
Externí odkaz:
https://doaj.org/article/7e2f740d0cd742fc8a87d89a6ecacddd
Autor:
Flavia Flaviani, Natasha L. Hezelgrave, Tokuwa Kanno, Erica M. Prosdocimi, Evonne Chin-Smith, Alexandra E. Ridout, Djuna K. von Maydell, Vikash Mistry, William G. Wade, Andrew H. Shennan, Konstantina Dimitrakopoulou, Paul T. Seed, A. James Mason, Rachel M. Tribe
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The syndrome of spontaneous preterm birth (sPTB) presents a challenge to mechanistic understanding, effective risk stratification, and clinical management. Individual associations between sPTB, self-reported ethnic ancestry, vaginal microbiota, metab
Externí odkaz:
https://doaj.org/article/2cb446a32e994b038f2a02ad6794749e
Autor:
DeDe Kwun-Wai Man, Tokuwa Kanno, Giorgia Manzo, Brian D. Robertson, Jenny K. W. Lam, A. James Mason
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT The mycobacterial cell wall affords natural resistance to antibiotics. Antimicrobial peptides (AMPs) modify the surface properties of mycobacteria and can act synergistically with antibiotics from differing classes. Here, we investigate the
Externí odkaz:
https://doaj.org/article/30e2623b09474f2a90ca386387fab3dd
Autor:
Gabriella Honeth, Tommaso Schiavinotto, Federico Vaggi, Rebecca Marlow, Tokuwa Kanno, Ireneusz Shinomiya, Sara Lombardi, Bharath Buchupalli, Rosalind Graham, Patrycja Gazinska, Vernie Ramalingam, Joy Burchell, Anand D. Purushotham, Sarah E. Pinder, Attila Csikasz-Nagy, Gabriela Dontu
Publikováno v:
Stem Cell Reports, Vol 4, Iss 4, Pp 699-711 (2015)
Characterization of normal breast stem cells is important for understanding their role in breast development and in breast cancer. However, the identity of these cells is a subject of controversy and their localization in the breast epithelium is not
Externí odkaz:
https://doaj.org/article/bbeca0c301214be8a16770bbe217e578
Autor:
Jocelyn M. Choo, Tokuwa Kanno, Nur Masirah Mohd Zain, Lex E. X. Leong, Guy C. J. Abell, Julie E. Keeble, Kenneth D. Bruce, A. James Mason, Geraint B. Rogers
Publikováno v:
mSphere, Vol 2, Iss 1 (2017)
ABSTRACT The intestinal microbiome plays an essential role in regulating many aspects of host physiology, and its disruption through antibiotic exposure has been implicated in the development of a range of serious pathologies. The complex metabolic r
Externí odkaz:
https://doaj.org/article/298777f0fab047ae93c981850e0e4905
Autor:
Alexandra Le Bras, Shirin Issa Bhaloo, Wenduo Gu, Jingjing Cai, Yao Lu, Alka Saxena, Jiacheng Deng, Efthymios Fidanis, Hong Yuan, A. James Mason, Witold Nowak, Tokuwa Kanno, Jozef Dulak, Yao Xie, Qingbo Xu, Yanhua Hu
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Perivascular adipose tissue (PVAT) plays a vital role in maintaining vascular homeostasis. However, most studies ascribed the function of PVAT in vascular remodeling to adipokines
Objective: Perivascular adipose tissue (PVAT) plays a vital role in maintaining vascular homeostasis. However, most studies ascribed the function of PVAT in vascular remodeling to adipokines
Autor:
Natasha L. Hezelgrave, Erica M Prosdocimi, Alexandra Ridout, Vikash Mistry, Rachel M. Tribe, Konstantina Dimitrakopoulou, Evonne C. Chin-Smith, William G. Wade, Tokuwa Kanno, Djuna K von Maydell, Andrew Shennan, Paul T. Seed, A. James Mason, Flavia Flaviani
Publikováno v:
JCI Insight
The syndrome of spontaneous preterm birth (sPTB) presents a challenge to mechanistic understanding, effective risk stratification, and clinical management. Individual associations between sPTB, self-reported ethnic ancestry, vaginal microbiota, metab
Autor:
Karen Urtishak, Gerhardt Attard, Tokuwa Kanno, Shibu Thomas, Gary E. Mason, Byron Espina, Eugene Zhu, Natalie Hutnick, Mary Guckert, Adam del Corral, Mark Li, Angela Lopez-Gitlitz, Kim Chi, William Kevin Kelly, Evan Y. Yu, Karim Fizazi, Matthew Smith
Publikováno v:
Cancer Research. 82:4133-4133
In the phase 2 GALAHAD study (NCT02854436), the PARP inhibitor (PARPi) niraparib, was evaluated in heavily pre-treated patients with mCRPC and DNA-repair gene defects (DRD) who progressed after androgen-receptor (AR) targeted therapy and taxane-based
Autor:
Jeffrey Silber, Jason Norman, Tokuwa Kanno, Emily Crossette, Rose Szabady, Rajita Menon, Melissa Marko, Bernat Olle, Esi Lamousé-Smith
Publikováno v:
Inflammatory Bowel Diseases. 28:S65-S66
IBD patients can have reduced gut commensal abundance, relative expansion of pro-inflammatory taxa, and reduced microbial diversity and short-chain fatty acid production. FMT leads to clinical remission in some UC patients, but is a complex, nonscala