Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tokushige Nakano"'
Autor:
Hiroo Sasaki, Hidetaka Suga, Kazuhito Takeuchi, Yuichi Nagata, Hideyuki Harada, Tatsuma Kondo, Eiji Ito, Sachi Maeda, Mayu Sakakibara, Mika Soen, Tsutomu Miwata, Tomoyoshi Asano, Hajime Ozaki, Shiori Taga, Atsushi Kuwahara, Tokushige Nakano, Hiroshi Arima, Ryuta Saito
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe pituitary gland, regulating various hormones, is central in the endocrine system. As spontaneous recovery from hypopituitarism is rare, and exogenous-hormone substitution is clumsy, pituitary replacement via regenerative medicine, usi
Externí odkaz:
https://doaj.org/article/fa3826946c674bf6a78055b9986694d5
Autor:
Koichi Saito, Noriyuki Suzuki, Tokushige Nakano, Kiyoshi Higashi, Atsushi Kuwahara, Satoshi Ando, Takashi Mori
Publikováno v:
Toxicology. 378:1-9
Some chemicals are harmful in to light-exposed tissues such as skin and eyes. The 3T3 Neutral Red Uptake Phototoxicity Test has been validated and adopted by the Organization of Economic and Community Development (OECD) as a method of evaluating chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53d8e5c376facc22338c6238ac108fd
https://doi.org/10.1016/j.tox.2017.01.003
https://doi.org/10.1016/j.tox.2017.01.003
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1597
A three-dimensional (3D) tissue generated in vitro is a promising source to study developmental biology and regenerative medicine. In the last decade, Yoshiki Sasai's group have developed a 3D stem cell culture technique known as SFEBq and demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8637f3b2cefdd671edb55add2976682
https://pubmed.ncbi.nlm.nih.gov/28361307
https://pubmed.ncbi.nlm.nih.gov/28361307
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969470
A three-dimensional (3D) tissue generated in vitro is a promising source to study developmental biology and regenerative medicine. In the last decade, Yoshiki Sasai's group have developed a 3D stem cell culture technique known as SFEBq and demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::128f159efffa6b66af088b54ba88f078
https://doi.org/10.1007/978-1-4939-6949-4_2
https://doi.org/10.1007/978-1-4939-6949-4_2
Autor:
Nozomu Takata, Kiyotoshi Sekiguchi, Keiko Muguruma, Mototsugu Eiraku, Tokushige Nakano, Shigenobu Yonemura, Masako Kawada, Yoshiki Sasai, Koichi Saito, Satoshi Ando
Publikováno v:
Cell Stem Cell. 10:771-785
SummaryIn this report, we demonstrate that an optic cup structure can form by self-organization in human ESC culture. The human ESC-derived optic cup is much larger than the mouse ESC-derived one, presumably reflecting the species differences. The ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddedf4c11614d4c4e8c0f98648b6f2e5
https://doi.org/10.1016/j.stem.2012.05.009
https://doi.org/10.1016/j.stem.2012.05.009
Autor:
Ayaka Nishiyama, Tokushige Nakano, Hidetaka Suga, Kazuhiro Murakami, Keiko Muguruma, Shuh Narumiya, Hitoshi Niwa, Mototsugu Eiraku, Toshihiro Aramaki, Masatoshi Ohgushi, Hirofumi Suemori, Toshimasa Ishizaki, Michiru Matsumura, Morio Ueno, Yoshiki Sasai
Publikováno v:
Cell Stem Cell. 7:225-239
Summary Human embryonic stem cells (hESCs), unlike mouse ones (mESCs), are vulnerable to apoptosis upon dissociation. Here, we show that the apoptosis, which is of a nonanoikis type, is caused by ROCK-dependent hyperactivation of actomyosin and effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45ecee9a98f80f863a848be4823e044
https://doi.org/10.1016/j.stem.2010.06.018
https://doi.org/10.1016/j.stem.2010.06.018
Autor:
Keizo Matsushita, Mototsugu Eiraku, Tokushige Nakano, Hiroko Terasaki, Juthaporn Assawachananont, Hiroshi Shirai, Yoshiki Sasai, Shigenobu Yonemura, Atsushi Kuwahara, Koichi Saito, Toru Kimura, Michiko Mandai, Masayo Takahashi
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Retinal transplantation therapy for retinitis pigmentosa is increasingly of interest due to accumulating evidence of transplantation efficacy from animal studies and development of techniques for the differentiation of human embryonic stem cells (hES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7f0643396f2f298385db47eae5f124
https://doi.org/10.1073/pnas.1512590113
https://doi.org/10.1073/pnas.1512590113
Autor:
Akishi Onishi, Tokushige Nakano, Keizo Matsushita, Mototsugu Eiraku, Masayo Takahashi, Yuki Maekawa, Michiko Mandai, Atsushi Kuwahara, Naoshi Koide, Takashi Kitaoka, Kiyoshi Suzuma, Chikafumi Ozone
Publikováno v:
Current eye research. 41(4)
To establish a practical research tool for studying the pathogenesis of retinal ganglion cell (RGC) diseases, we optimized culture procedures to induce neurite outgrowth from three-dimensional self-organizing optic vesicles (3D-retinas) differentiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1619a0603e37cf7a304fccbaa66be4
https://pubmed.ncbi.nlm.nih.gov/25880804
https://pubmed.ncbi.nlm.nih.gov/25880804
Autor:
Atsushi Kuwahara, Yoshiki Sasai, Tokushige Nakano, Koichi Saito, Chikafumi Ozone, Mototsugu Eiraku
Publikováno v:
Nature communications. 6
In the developing neural retina (NR), multipotent stem cells within the ciliary margin (CM) contribute to de novo retinal tissue growth. We recently reported the ability of human embryonic stem cells (hESCs) to self-organize stratified NR using a thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728ab96cfbf5e5f325d4bd3b98652cd2
https://pubmed.ncbi.nlm.nih.gov/25695148
https://pubmed.ncbi.nlm.nih.gov/25695148
Autor:
Satoshi Ando, Mototsugu Eiraku, Yoshiki Sasai, Tokushige Nakano, Hideya Sakaguchi, Mika Soen, Taisuke Kadoshima
Here, using further optimized 3D culture that allows highly selective induction and long-term growth of human ES cell (hESC)-derived cortical neuroepithelium, we demonstrate unique aspects of self-organization in human neocorticogenesis. Self-organiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3f55954d2ce7085f5d2469ad475116
https://europepmc.org/articles/PMC3864329/
https://europepmc.org/articles/PMC3864329/