Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tokushi Hanano"'
Autor:
Jun-ichi Eguchi, Shinsuke Hiki, Masatake Fujimura, Satoshi Yuki, Shinji Sunada, Tokushi Hanano, Masahiro Okuyama, Fumiaki Uehara, Toshiyuki Kohara, Hiroshi Tanaka, Keiichi Aritomo, Susumu Tsuchiya, Ken-Ichi Saito, Kenji Fukunaga, Kazutoshi Watanabe, Shoichi Asano, Koichi Yamakoshi, Hiroshi Baba, Shinji Tanaka, Takashi Horikawa, Yoshihiro Usui, Aya Shoda, Akiko Mori, Keiji Yamagami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6933-6937
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g
Autor:
Tetsuro Fujita, Masatoshi Kiuchi, Yoshiyuki Aoki, Koji Teshima, Yukio Hoshino, Tadashi Mishina, Kunitomo Yoshitomi Phar Adachi, Masanori Minoguchi, Tokushi Hanano, Masafumi Arita, Toshiyuki Yoshitomi Pharmaceutical Ind.Ltd. Kohara, Makio Ohtsuki, Noriyoshi Nakao, Kenji Chiba, Shigeo Sasaki
Publikováno v:
Journal of Medicinal Chemistry. 43:2946-2961
A series of 2-substituted 2-aminopropane-1,3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat skin allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, whic
Autor:
Hiroshi Morimoto, Tokushi Hanano, Kunitomo Adachi, Masao Hisadome, Tetsuko Fukuda, Hiroshi Sumichika, Yoshiyuki Aoki, Yoichi Naka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:881-884
A series of arylpiperazine derivatives was synthesized to obtain agents showing apparent therapeutic effects in a chronic inflammatory animal model, starting from a lead possessing potent dual cytokine regulatory activity in vivo. We found a pyrimidy
Autor:
Hiroshi Morimoto, Yoshiyuki Aoki, Tetsuko Fukuda, Tokushi Hanano, Yoichi Naka, Hiroshi Sumichika, Kunitomo Adachi, Masao Hisadome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:875-879
Phenylpiperazine derivatives were synthesized as dual cytokine regulators with TNF-α suppressing and IL-10 augmenting activity. Lead optimization led to compound 5k Scheme 2. Reagents and conditions: (a) Ac2O, NaOH, H2O, rt (87%); (b) cH2SO4, MeOH,
Autor:
Tokushi Hanano, Tetsuko Fukuda, Hiroshi Sumichika, Kunitomo Adachi, Masao Hisadome, Meguru Murata
Publikováno v:
European Journal of Pharmacology. 391:317-320
A pyrimidylpiperazine derivative, N-[1-(4-¿[4-(pyrimidin-2-yl)piperazin-1-yl]methyl¿phenyl)cycloprop yl] acetamide (Y-39041), is a dual cytokine regulator of tumor necrosis factor (TNF)-alpha and interleukin-10 production. Lipopolysaccharide-induce
Publikováno v:
Tetrahedron. 53:6825-6834
α-Iodination reaction of 4-alkenylamide with a β-chiral center proceeds with high diastereoselectivity to give syn α-iodoalkenamide through the formation of cyclic ketene N , O -acetal and subsequent α-iodination from the opposite side of a β-su
Autor:
Osamu Kitagawa, Tomomi Yamazaki, Takeo Taguchi, Tokushi Hanano, Norihiko Kikuchi, Midori Okada, Katsuyuki Aoki
Publikováno v:
The Journal of Organic Chemistry. 60:7161-7165
Publikováno v:
Tetrahedron Letters. 34:2165-2168
The α-iodination reaction of chiral enamides 1 possessing (2R,5R)-2,5-bis(methoxymethyl)pyrrolidine as a chiral auxiliary proceeded with high diastereoselectivity in the presence of I 2 and s-collidine. The chiral iodides 2 thus obtained were conver
Publikováno v:
ChemInform. 24
The α-iodination reaction of chiral enamides 1 possessing (2R,5R)-2,5-bis(methoxymethyl)pyrrolidine as a chiral auxiliary proceeded with high diastereoselectivity in the presence of I 2 and s-collidine. The chiral iodides 2 thus obtained were conver
Publikováno v:
ChemInform. 23
Enantioselective halocyclizations of diallyl-2-hydroxyacetic acid 1 and 2-hydroxymethylpent-4-en-1-ol 6 have been developed using a chiral titanium complex.