A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic.

Autor: Cohen JR; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA. jcohen02@amgen.com., Brych SR; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Prabhu S; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Bi V; The Department of Biosimilars, Amgen Inc, Thousand Oaks, CA, 91320, USA., Elbaradei A; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Tokuda JM; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Xiang C; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Hokom M; The Department of Clinical Immunology, Amgen Inc, Thousand Oaks, CA, 91320, USA.; Department of BioAnalytical Sciences, Genentech, Inc, South San Francisco, CA, 94080, USA., Cui X; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Ly C; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Amos N; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Sun J; Translational Safety and Bioanalytical Sciences, Amgen Inc, Thousand Oaks, CA, 91320, USA., Calamba D; Translational Safety and Bioanalytical Sciences, Amgen Inc, Thousand Oaks, CA, 91320, USA., Herskovitz J; The Department of Clinical Immunology, Amgen Inc, Thousand Oaks, CA, 91320, USA.; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Capili A; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Nourbakhsh K; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Merlo A; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Carreon J; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Wypych J; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Narhi LO; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA., Jawa V; The Department of Clinical Immunology, Amgen Inc, Thousand Oaks, CA, 91320, USA.; Department of Pharmacometrics, Disposition & Bioanalysis, Bristol Myers Squibb, Princeton, NJ, 08543, USA., Joubert MK; The Department of Process Development, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA, 91320, USA. mjoubert@amgen.com.

Publikováno v: Pharmaceutical research [Pharm Res] 2024 Apr; Vol. 41 (4), pp. 651-672. Date of Electronic Publication: 2024 Mar 22.

Local DNA Sequence Controls Asymmetry of DNA Unwrapping from Nucleosome Core Particles.

Autor: Mauney AW; School of Applied and Engineering Physics, Cornell University, Ithaca, New York., Tokuda JM; School of Applied and Engineering Physics, Cornell University, Ithaca, New York., Gloss LM; School of Molecular Biosciences, Washington State University, Pullman, Washington., Gonzalez O; Department of Mathematics, University of Texas, Austin, Texas., Pollack L; School of Applied and Engineering Physics, Cornell University, Ithaca, New York. Electronic address: lp26@cornell.edu.

Publikováno v: Biophysical journal [Biophys J] 2018 Sep 04; Vol. 115 (5), pp. 773-781. Date of Electronic Publication: 2018 Jul 31.

Structural changes of tailless bacteriophage ΦX174 during penetration of bacterial cell walls.

Autor: Sun Y; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907., Roznowski AP; The BIO5 Institute, University of Arizona, Tucson, AZ 85721., Tokuda JM; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853., Klose T; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907., Mauney A; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853., Pollack L; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853., Fane BA; The BIO5 Institute, University of Arizona, Tucson, AZ 85721., Rossmann MG; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907; mr@purdue.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Dec 26; Vol. 114 (52), pp. 13708-13713. Date of Electronic Publication: 2017 Dec 11.

Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.

Autor: Yan M; T. C. Jenkins Department of Biophysics, Johns Hopkins University , Baltimore, Maryland 21218, United States.; Department of Biology, Johns Hopkins University , Baltimore, Maryland 21218, United States., Chakravarthy S; Biophysics Collaborative Access Team, Argonne National Laboratory , Argonne, Illinois 60439, United States., Tokuda JM; School of Applied and Engineering Physics, Cornell University , Ithaca, New York 14853, United States., Pollack L; School of Applied and Engineering Physics, Cornell University , Ithaca, New York 14853, United States., Bowman GD; T. C. Jenkins Department of Biophysics, Johns Hopkins University , Baltimore, Maryland 21218, United States., Lee YS; Department of Biology, Johns Hopkins University , Baltimore, Maryland 21218, United States.

Publikováno v: Biochemistry [Biochemistry] 2016 Aug 23; Vol. 55 (33), pp. 4731-6. Date of Electronic Publication: 2016 Aug 11.

Revealing transient structures of nucleosomes as DNA unwinds.

Autor: Chen Y; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA., Tokuda JM; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA., Topping T; School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA., Sutton JL; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA., Meisburger SP; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA., Pabit SA; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA., Gloss LM; School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA., Pollack L; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA lp26@cornell.edu.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2014 Jul; Vol. 42 (13), pp. 8767-76. Date of Electronic Publication: 2014 Jul 02.