Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Tohru Sugawara"'
Publikováno v:
Regenerative Therapy, Vol 21, Iss , Pp 37-45 (2022)
Introduction: In a diploid organism, two alleles from a single genetic locus are expressed to generate a normal phenotype. Heterozygous deleterious mutation causes a reduction of functional proteins to a half dose and insufficient amounts of function
Externí odkaz:
https://doaj.org/article/b6a954a58de245248d7c20196754fcdc
Publikováno v:
Regenerative Therapy, Vol 15, Iss , Pp 1-9 (2020)
Introduction: Recent studies have revealed that microRNAs (miRNAs, miRs) are important for self-renewal, differentiation, and cellular reprogramming of somatic cells into induced pluripotent stem cells (iPSC); however, their functional roles and targ
Externí odkaz:
https://doaj.org/article/0b6fa968a6424e48ac08760a0cd061c7
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100811- (2021)
Summary: We recently demonstrated that the zygotic gene Zscan5b is involved in maintaining the genomic integrity of pluripotent stem cells (PSCs) during mitosis and that Zscan5b gene expression can prevent chromosomal abnormalities. Here, we provide
Externí odkaz:
https://doaj.org/article/307412d1808d4afbb8cc01cf6daea95c
Autor:
Seiji Ogawa, Mitsutoshi Yamada, Akihiro Nakamura, Tohru Sugawara, Akari Nakamura, Shoko Miyajima, Yuichirou Harada, Reina Ooka, Ryuichiro Okawa, Jun Miyauchi, Hideki Tsumura, Yasunori Yoshimura, Kenji Miyado, Hidenori Akutsu, Mamoru Tanaka, Akihiro Umezawa, Toshio Hamatani
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1366-1379 (2019)
Summary: Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA genes prevent mitotic errors. Here we show that knockout of the ZGA gene Zscan5b,
Externí odkaz:
https://doaj.org/article/67cc7691016f4a3ab0a87d7145974e7f
Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors
Autor:
Koichiro Nishino, Yoshikazu Arai, Ken Takasawa, Masashi Toyoda, Mayu Yamazaki-Inoue, Tohru Sugawara, Hidenori Akutsu, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Akihiro Umezawa
Publikováno v:
Regenerative Therapy, Vol 9, Iss , Pp 71-78 (2018)
Human induced pluripotent stem cells (iPSCs) are established by introducing several reprogramming factors, such as OCT3/4, SOX2, KLF4, c-MYC. Because of their pluripotency and immortality, iPSCs are considered to be a powerful tool for regenerative m
Externí odkaz:
https://doaj.org/article/89e5fef2aed349748299b4161679e9d0
Autor:
Takumi Miura, Tohru Sugawara, Atsushi Fukuda, Ryo Tamoto, Tomoyuki Kawasaki, Akihiro Umezawa, Hidenori Akutsu
Publikováno v:
Biology Open, Vol 4, Iss 11, Pp 1595-1607 (2015)
In mice, leukemia inhibitory factor (LIF)-dependent primitive neural stem cells (NSCs) have a higher neurogenic potential than bFGF-dependent definitive NSCs. Therefore, expandable primitive NSCs are required for research and for the development of t
Externí odkaz:
https://doaj.org/article/ae766291b4a4476e8f0fdea335ee28c2
Autor:
Hidenori Akutsu, Masakazu Machida, Seiichi Kanzaki, Tohru Sugawara, Takashi Ohkura, Naoko Nakamura, Mayu Yamazaki-Inoue, Takumi Miura, Mohan C. Vemuri, Mahendra S. Rao, Kenji Miyado, Akihiro Umezawa
Publikováno v:
Regenerative Therapy, Vol 1, Iss C, Pp 18-29 (2015)
The potential applications of human embryonic stem cells (hESCs) in regenerative medicine and developmental research have made stem cell biology one of the most fascinating and rapidly expanding fields of biomedicine. The first clinical trial of hESC
Externí odkaz:
https://doaj.org/article/ff9fe3a75f5746b88b5dd394039fb3d7
Autor:
Noriko Okumura, Hidenori Akutsu, Tohru Sugawara, Takumi Miura, Youki Takezawa, Akihiro Hosoda, Keiichi Yoshida, Justin K Ichida, Mitsutoshi Yamada, Toshio Hamatani, Naoaki Kuji, Kenji Miyado, Yasunori Yoshimura, Akihiro Umezawa
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout embryogenesis and tissue homeostasis. β-Catenin, encoded by the Ctnnb1 gene, mediates an intra
Externí odkaz:
https://doaj.org/article/043296df482f44cb8877cb30e7e9b803
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43277 (2012)
Chimpanzees (Pan troglodytes) have region-specific difference in dietary repertoires from East to West across tropical Africa. Such differences may result from different genetic backgrounds in addition to cultural variations. We analyzed the sequence
Externí odkaz:
https://doaj.org/article/b18643706b38459bbcea29a8d53a9c9f
Autor:
Yohey Terai, Ole Seehausen, Takeshi Sasaki, Kazuhiko Takahashi, Shinji Mizoiri, Tohru Sugawara, Tetsu Sato, Masakatsu Watanabe, Nellie Konijnendijk, Hillary D J Mrosso, Hidenori Tachida, Hiroo Imai, Yoshinori Shichida, Norihiro Okada
Publikováno v:
PLoS Biology, Vol 4, Iss 12, p e433 (2006)
Divergent natural selection acting on ecological traits, which also affect mate choice, is a key element of ecological speciation theory, but has not previously been demonstrated at the molecular gene level to our knowledge. Here we demonstrate paral
Externí odkaz:
https://doaj.org/article/db74b4f4e1ff413c98f42d5c3cf35594