Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Tohru Miyazaki"'
Autor:
Takahito Hara, Akiko Kimura, Tohru Miyazaki, Hiroshi Tanaka, Megumi Morimoto, Katsuhiko Nakai, Junpei Soeda
Publikováno v:
Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100797- (2020)
Externí odkaz:
https://doaj.org/article/2a65e57fdf3a42a3a16790812ebf494e
Autor:
Takahito Hara, Akiko Kimura, Tohru Miyazaki, Hiroshi Tanaka, Megumi Morimoto, Katsuhiko Nakai, Junpei Soeda
Publikováno v:
Biochemistry and Biophysics Reports, Vol 21, Iss , Pp - (2020)
Cabozantinib is known as an inhibitor of receptor tyrosine kinases mainly targeting AXL receptor tyrosine kinase (AXL), MET proto-oncogene-encoded receptor tyrosine kinase (MET), and vascular endothelial growth factor receptor 2. Growth arrest-specif
Externí odkaz:
https://doaj.org/article/424e8fa62fb243a695d637d357b245ab
Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.
Autor:
Aiko Murai, Shunsuke Ebara, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Toshiyuki Nomura, Shinsuke Araki
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240718 (2020)
Emerging evidence indicates that alternative splicing plays a critical role in cancer progression through abnormal expression or mutation of splicing factors. Small-molecule splicing modulators have recently attracted considerable attention as a nove
Externí odkaz:
https://doaj.org/article/d70071ab62df463cb60eee743a603d5b
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Katsuya Morito, Ryota Shimizu, Hanif Ali, Akina Shimada, Tohru Miyazaki, Naoko Takahashi, Rahman, M. Motiur, Kazuki Tsuji, Nobuyuki Shimozawa, Michiyasu Nakao, Shigeki Sano, Momoyo Azuma, Nanjundan, Meera, Kentaro Kogure, Tamotsu Tanaka
Publikováno v:
Journal of Medical Investigation; 2023, Vol. 70 Issue 3/4, p403-410, 8p
Autor:
Toshiyuki Nomura, Hiroshi Sugimoto, Noriko Uchiyama, Akihiro Ohashi, Hideto Hara, Takashi Imada, Yukiko Yamamoto, Isaac Hoffman, Kenichi Iwai, Momoko Ohori, Misaki Homma, Osamu Kurasawa, Nobuo Cho, Tohru Miyazaki, Yuya Oguro, Kentaro Iwata, Robert J. Skene
Publikováno v:
Journal of Medicinal Chemistry. 63:1084-1104
In our pursuit of developing a novel, potent, and selective cell division cycle 7 (Cdc7) inhibitor, we optimized the previously reported thieno[3,2-d]pyrimidinone analogue I showing time-dependent Cdc7 kinase inhibition and slow dissociation kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302cc8787b4b0af51ff2d819e10565ac
https://doi.org/10.1021/acs.jmedchem.9b01427
https://doi.org/10.1021/acs.jmedchem.9b01427
Autor:
Akio Imanishi, Masanori Kawasaki, Tatsuki Koike, Takamitsu Maru, Atsushi Suzuki, Tohru Miyazaki, Tomohiro Kawamoto, Yuki Ito
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:815-820
The voltage-gated sodium channel, Nav1.1, is predominantly expressed in parvalbumin-positive fast spiking interneurons and has been genetically linked to Dravet syndrome. Starting from a high throughput screening hit isoxazole derivative 5, modificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97b7ab54b1f201a12abb5a8c3a0ba881
https://doi.org/10.1016/j.bmcl.2019.01.023
https://doi.org/10.1016/j.bmcl.2019.01.023
Autor:
Shunsuke Ebara, Tomohiro Ohashi, Aiko Murai, Toshiyuki Nomura, Satoshi Sasaki, Tohru Miyazaki, Shinsuke Araki
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240718 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240718 (2020)
Emerging evidence indicates that alternative splicing plays a critical role in cancer progression through abnormal expression or mutation of splicing factors. Small-molecule splicing modulators have recently attracted considerable attention as a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e215d6b9e1ce028e2c2a793c28fd3300
http://europepmc.org/articles/PMC7567398
http://europepmc.org/articles/PMC7567398
Autor:
Junpei Soeda, Akiko Kimura, Megumi Morimoto, Katsuhiko Nakai, Takahito Hara, Hiroshi Tanaka, Tohru Miyazaki
Publikováno v:
Biochem Biophys Rep
Biochemistry and Biophysics Reports, Vol 24, Iss, Pp 100797-(2020)
Biochemistry and Biophysics Reports, Vol 24, Iss, Pp 100797-(2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdb7e86fc9fd11140828502dda60f3e
https://europepmc.org/articles/PMC7767797/
https://europepmc.org/articles/PMC7767797/
Autor:
Osamu, Kurasawa, Tohru, Miyazaki, Misaki, Homma, Yuya, Oguro, Takashi, Imada, Noriko, Uchiyama, Kenichi, Iwai, Yukiko, Yamamoto, Momoko, Ohori, Hideto, Hara, Hiroshi, Sugimoto, Kentaro, Iwata, Robert, Skene, Isaac, Hoffman, Akihiro, Ohashi, Toshiyuki, Nomura, Nobuo, Cho
Publikováno v:
Journal of medicinal chemistry. 63(3)
In our pursuit of developing a novel, potent, and selective cell division cycle 7 (Cdc7) inhibitor, we optimized the previously reported thieno[3,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65206dbfb7f69de0b5181ef73a51d57d
https://pubmed.ncbi.nlm.nih.gov/31895562
https://pubmed.ncbi.nlm.nih.gov/31895562