Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Tohru Kodama"'
Autor:
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which is a well-defined type of central disorders of hypersomnolence, the etiology of IH is
Externí odkaz:
https://doaj.org/article/d07ab5f0adcd4703970a8ce887df5b95
Autor:
Mamiko Koshiba, Aya Watarai-Senoo, Genta Karino, Shimpei Ozawa, Yoshimasa Kamei, Yoshiko Honda, Ikuko Tanaka, Tohru Kodama, Setsuo Usui, Hironobu Tokuno
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2021)
The prevalence of neurodevelopmental psychiatric disorders such as pervasive developmental disorders is rapidly increasing worldwide. Although these developmental disorders are known to be influenced by an individual’s genetic background, the poten
Externí odkaz:
https://doaj.org/article/1c049925e4c844d083e16c73cded0533
Autor:
Hiromi Toyoda, Yoshiko Honda, Susumu Tanaka, Taku Miyagawa, Makoto Honda, Kazuki Honda, Katsushi Tokunaga, Tohru Kodama
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187888 (2017)
Narcolepsy is caused by the loss of hypocretin (Hcrt) neurons and is associated with multiple genetic and environmental factors. Although abnormalities in immunity are suggested to be involved in the etiology of narcolepsy, no decisive mechanism has
Externí odkaz:
https://doaj.org/article/4f86e68c60984cadb887f8e4aac0b43d
Autor:
Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Haruo Okado, Tohru Kodama, Masahiko Takada
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75975 (2013)
Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals. The functional relevance of D5 dopamine receptors in t
Externí odkaz:
https://doaj.org/article/6a4671a1bceb400a8c27c908ded610bf
Autor:
Sachiko Chikahisa, Tohru Kodama, Atsushi Soya, Yohei Sagawa, Yuji Ishimaru, Hiroyoshi Séi, Seiji Nishino
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78434 (2013)
Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine
Externí odkaz:
https://doaj.org/article/41515e1aeb9b4da9aa58b16ee6b3ac30
Publikováno v:
Kinases and Phosphatases; Volume 1; Issue 1; Pages: 14-22
Serine/threonine-protein kinase 16 (STK16) is a novel member of the Numb-associated family of protein kinases with an atypical kinase domain. In this study, we aimed to investigate the involvement of STK16 in sleep–wake mechanisms. We confirmed the
Autor:
Tohru Kodama, Takashi Kojima, Yoshiko Honda, Takayuki Hosokawa, Akihiro Karashima, Masataka Watanabe
Neuroimaging studies have demonstrated the presence of a default mode network (DMN) which shows greater activity during rest, and an executive network (EN) which is activated during cognitive tasks. DMN and EN are thought to have competing functions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::966422ec092c87b0e54ca5449e08b6f6
https://doi.org/10.1101/2023.03.19.533320
https://doi.org/10.1101/2023.03.19.533320
Autor:
Koichi Hirata, Akiko Hida, Naoto Yamada, Masayuki Miyamoto, Yuichi Kamei, Kenji Kuroda, Makoto Honda, Yu Ariyoshi, Kazuhiko Kume, Takao Kato, Tohru Kodama, Mihoko Shimada, Hiromi Toyoda, Aya Imanishi, Tatayu Kotorii, Nozomu Kotorii, Naoto Omata, Naohisa Uchimura, Masanori Takami, Yuichi Inoue, Motohiro Ozone, Kotomi Tanida, Hideaki Kondo, Kazuo Mishima, Takashi Kanbayashi, Azusa Ikegami, Katsushi Tokunaga, Taku Miyagawa, Seik-Soon Khor, Kayoko Kato, Yamato Wada, Masako Okawa, Hiroshi Hiejima
Publikováno v:
Sleep and Biological Rhythms. 20:137-148
Idiopathic hypersomnia (IH) is a rare sleep disorder characterized by excessive daytime sleepiness, great difficulty upon awakening, and prolonged sleep time. In contrast to narcolepsy type 1, which is a well-recognized hypersomnia, the etiology of I
Autor:
Shizuka Takaku, Souichi Oe, Taro Koike, Yasuharu Takamori, Takashi Yoshida, Nae Takizawa, Kiyoshi Kurokawa, Susumu Tanaka, Yukie Hirahara, Tohru Kodama, Yoshiko Honda, Hisao Yamada
Publikováno v:
International Journal of Molecular Medicine
The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene-like 1 (Plagl1), which encodes a C2H2 zinc-finger tran
Autor:
Akihiro Karashima, Naoya Kabe, Andrea Trevisiol, Makoto Honda, Kazuto Masamoto, Tomomi Tsunematsu, Kenji F. Tanaka, Tomomi Sanagi, Norio Takata, Akiyo Natsubori, Klaus-Armin Nave, Ko Matsui, Hiromi Imamura, Tohru Kodama, Johannes Hirrlinger
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Whilst the brain is assumed to exert homeostatic functions to keep the cellular energy status constant under physiological conditions, this has not been experimentally proven. Here, we conducted in vivo optical recordings of intracellular concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d837fb467ae05705705fa79dac4981
https://hdl.handle.net/21.11116/0000-000A-2927-D21.11116/0000-000A-2923-1
https://hdl.handle.net/21.11116/0000-000A-2927-D21.11116/0000-000A-2923-1