Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Tohru Fuwa"'
Autor:
Masafumi Misaki, Tohru Fuwa, Teruo Murakami, Yutaka Higashi, Manami Yuki, Yoshie Kojima, Noboru Yata, Mie Yamada, Harunobu Amagase
Publikováno v:
Journal of Pharmaceutical Sciences. 82:236-239
Subcutaneous administration of human epidermal growth factor (hEGF) to rats gave a significantly smaller value of area under the curve (AUC) of concentration in plasma of immunoreactive hEGF versus time than intravenous administration, probably becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd183dba2e1b42461885aed98094d7d
https://doi.org/10.1002/jps.2600820303
https://doi.org/10.1002/jps.2600820303
Publikováno v:
Biological and Pharmaceutical Bulletin. 16:73-76
The systemic effects of epidermal growth factor (EGF) ointment containing nafamostat (NM), gabexate, or gelatin was studied in rats with burns or open wounds. At 1 d after burn, plasma epinephrine, cortisol, and glutamic-oxalacetic transaminase (GOT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e648c1b07ba07cff9e6a002ad4a60dce
https://doi.org/10.1248/bpb.16.73
https://doi.org/10.1248/bpb.16.73
Autor:
Susumu Yoshida, Hiroaki Furutani, Hiroshi Naganawa, Tomio Takeuchi, Yumi Mori, Ryuichi Sawa, Hironobu Iinuma, Yoshio Kajimura, Masa Hamada, Tohru Fuwa
Publikováno v:
ChemInform. 25
Clinical efficacy of arbekacin (ABK) was examined on patients with MRSA infection during hospitalization in Nagoya University Hospital. A total of 15 analysed cases of 5 sepsis, 3 pneumonias, 6 wound infections and one abdominal abscess. ABK was admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e56ec4d781c68c64a7de4018eafa106
https://doi.org/10.1002/chin.199452264
https://doi.org/10.1002/chin.199452264
Autor:
Yasufumi Sawada, Hiroshi Suzuki, Yukio Kato, Hiroaki Sato, Manabu Hanano, Makoto Ichikawa, Yuichi Sugiyama, Tohru Fuwa
Publikováno v:
Proceedings of the National Academy of Sciences. 89:8507-8511
The effect of phenylarsine oxide (PAO) on the internalization rate of epidermal growth factor (EGF) was investigated using perfused rat liver and isolated rat hepatocytes. In perfused liver, a tracer concentration of 125I-EGF alone or with excess unl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abeebd89a147b288e337db917654b45
https://doi.org/10.1073/pnas.89.18.8507
https://doi.org/10.1073/pnas.89.18.8507
Autor:
Hiroshi Koide, Shigeyuki Yokoyama, Kumiko Hoshi, Hidefumi Kasai, Daisuke Kohda, Tetsuo Miyake, Seizo Takahashi, Tetsuyuki Sasaki, Fuyuhiko Inagaki, Kaoru Kohri, Ken ichi Tsukumo, Takanori Oka, Tatsuo Miyazawa, Yutaka Muto, Tohru Fuwa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1120:257-261
The isoleucine-23 residue of human epidermal growth factor (hEGF) was substituted by a variety of amino acid residues and the receptor-binding activities of variant hEGFs were determined by the use of human KB cell. Tight receptor binding was found o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64beb9afbe7ee4fdf44db0da5a87588
https://doi.org/10.1016/0167-4838(92)90245-9
https://doi.org/10.1016/0167-4838(92)90245-9
Publikováno v:
Pharmaceutical Research. :557-562
We compared methods for determining the distribution of epidermal growth factor (EGF) receptors between the cell surface and the cell interior in the rat liver. Incubation of isolated hepatocytes with 100 nM EGF for 20 min at 37°C remarkably decreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e497ddbd6e06f9fb33be64d5bd5024
https://doi.org/10.1023/a:1015836219502
https://doi.org/10.1023/a:1015836219502
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 258:G682-G689
The internalization rate of epidermal growth factor (EGF) by the perfused rat liver was evaluated to determine whether the internalization rate constant depends on the degree of receptor occupancy. A tracer concentration of 125I-labeled EGF (30 pM) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7400407f4ada9e1eaa4e76d10ec1eddd
https://doi.org/10.1152/ajpgi.1990.258.5.g682
https://doi.org/10.1152/ajpgi.1990.258.5.g682
Autor:
Ken Hashimoto, Hirotaka Amano, Masanori Kakimoto, Masayasu Okuhira, Tohru Fuwa, Kouichi Tamura, Harunobu Amagase, Shigeru Tsukagoshi
Publikováno v:
Japanese Journal of Cancer Research : Gann
We observed that human epidermal growth factor (hEGF) alone prolonged the survival time of mice bearing various murine syngeneic tumors as well as athymic nude mice bearing human xenografts. No changes in the subcutaneous solid tumor mass volume were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925e4cdf1b1126279585fb41e6b6285a
https://doi.org/10.1111/j.1349-7006.1990.tb02597.x
https://doi.org/10.1111/j.1349-7006.1990.tb02597.x
Publikováno v:
Pharmaceutical Research. :1289-1293
The healing effect of human epidermal growth factor (hEGF) on open wounds was studied in rats. No improvement in wound healing was found by topical application of EGF alone to open wound sites. We found an ointment containing EGF and a protease inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8f9df759947ece5e821ff6f111cd6c
https://doi.org/10.1023/a:1015946123697
https://doi.org/10.1023/a:1015946123697
Publikováno v:
Journal of Pharmacobio-Dynamics. 13:263-268
We previously demonstrated that the antitumor efficacy of various antitumor agents such as 5-fluorouracil and cisplatin against experimental solid tumors was enhanced by pre- or simultaneous administration of human epidermal growth factor (hEGF). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c994e8e1b782d6d65c1c70fe040d6d15
https://doi.org/10.1248/bpb1978.13.263
https://doi.org/10.1248/bpb1978.13.263