Zobrazeno 1 - 10
of 495
pro vyhledávání: '"Tohru Funahashi"'
Autor:
Jun Murai, Hitoshi Nishizawa, Akihito Otsuka, Shiro Fukuda, Yoshimitsu Tanaka, Hirofumi Nagao, Yasuna Sakai, Masahide Suzuki, Shinji Yokota, Hidetoshi Tada, Mayumi Doi, Yuya Fujishima, Shunbun Kita, Tohru Funahashi, Norikazu Maeda, Tadashi Nakamura, Iichiro Shimomura
Publikováno v:
Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract Background Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia in the elderly have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength, and quality) and car
Externí odkaz:
https://doaj.org/article/db18d9df0446418f9b89701b3ce1c05d
Autor:
Mitsunobu Kubota, Masayasu Yoneda, Norikazu Maeda, Haruya Ohno, Kenji Oki, Tohru Funahashi, Iichiro Shimomura, Noboru Hattori
Publikováno v:
Cardiovascular Diabetology, Vol 16, Iss 1, Pp 1-7 (2017)
Abstract Background Although Japanese–Americans and native Japanese share the same genetic predispositions, they live different lifestyles, resulting in insulin resistance in Japanese–Americans. We investigated whether the quantitative and qualit
Externí odkaz:
https://doaj.org/article/4e7fc1afc8064a37a198c9590323fbcd
Tracing the movement of adiponectin in a parabiosis model of wild-type and adiponectin-knockout mice
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 276-282 (2014)
Adiponectin is exclusively synthesized by adipocytes and exhibits anti-diabetic, anti-atherosclerotic and anti-inflammatory properties. Hypoadiponectinemia is associated in obese individuals with insulin resistance and atherosclerosis. However, the m
Externí odkaz:
https://doaj.org/article/5d728f07e9ec4805a5e27858eed6ebde
Autor:
Kieren J Mather, Qing Pan, William C Knowler, Tohru Funahashi, George A Bray, Richard Arakaki, Bonita Falkner, Kumar Sharma, Barry J Goldstein, DPP Research Group
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136853 (2015)
BACKGROUND AND OBJECTIVES:Molecular data suggests that adiponectin may directly regulate urinary albumin excretion. In the Diabetes Prevention Program (DPP) we measured adiponectin and albuminuria before and after intervention, and we previously repo
Externí odkaz:
https://doaj.org/article/c3d7ba80564945cca5a139b52282f3da
Autor:
Kana Inoue, Norikazu Maeda, Takuya Mori, Ryohei Sekimoto, Yu Tsushima, Keisuke Matsuda, Masaya Yamaoka, Takayoshi Suganami, Hitoshi Nishizawa, Yoshihiro Ogawa, Tohru Funahashi, Iichiro Shimomura
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87661 (2014)
Obesity is an epidemic matter increasing risk for cardiovascular diseases and metabolic disorders such as type 2 diabetes. We recently examined the association between visceral fat adiposity and gene expression profile of peripheral blood cells in hu
Externí odkaz:
https://doaj.org/article/b1ed7ee981f14df4ab429dfee2bb43e3
Autor:
Masaya Yamaoka, Norikazu Maeda, Yasunori Takayama, Ryohei Sekimoto, Yu Tsushima, Keisuke Matsuda, Takuya Mori, Kana Inoue, Hitoshi Nishizawa, Makoto Tominaga, Tohru Funahashi, Iichiro Shimomura
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112813 (2014)
Visceral fat adiposity plays an important role in the development of metabolic syndrome. We reported previously the impact of human visceral fat adiposity on gene expression profile of peripheral blood cells. Genes related to circadian rhythm were hi
Externí odkaz:
https://doaj.org/article/867d27d1132947d8862fee1e4de78586
Autor:
Takuya Mori, Norikazu Maeda, Kana Inoue, Ryohei Sekimoto, Yu Tsushima, Keisuke Matsuda, Masaya Yamaoka, Takayoshi Suganami, Hitoshi Nishizawa, Yoshihiro Ogawa, Tohru Funahashi, Iichiro Shimomura
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76199 (2013)
AIMS: Ephrin-B1 (EfnB1) was selected among genes of unknown function in adipocytes or adipose tissue and subjected to thorough analysis to understand its role in the development of obesity. METHODS AND RESULTS: EfnB1 mRNA and protein levels were sign
Externí odkaz:
https://doaj.org/article/6a480f8ce1e941a68862b5c0ddbb4305
Autor:
Noriyuki Komura, Norikazu Maeda, Takuya Mori, Shinji Kihara, Hideaki Nakatsuji, Ayumu Hirata, Yoshihiro Tochino, Tohru Funahashi, Iichiro Shimomura
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71271 (2013)
AIMS: Inflammation is closely associated with the development of atherosclerosis and metabolic syndrome. Adiponectin, an adipose-derived secretory protein, possesses an anti-atherosclerotic property. The present study was undertaken to elucidate the
Externí odkaz:
https://doaj.org/article/ec8a8c467a8649dd8a3e20234956cd2a
Autor:
Masaya Yamaoka, Norikazu Maeda, Seiji Nakamura, Susumu Kashine, Yasuhiko Nakagawa, Aki Hiuge-Shimizu, Kohei Okita, Akihisa Imagawa, Yuji Matsuzawa, Ken-ichi Matsubara, Tohru Funahashi, Iichiro Shimomura
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47377 (2012)
Evidence suggests that visceral fat accumulation plays a central role in the development of metabolic syndrome. Excess visceral fat causes local chronic low-grade inflammation and dysregulation of adipocytokines, which contribute in the pathogenesis
Externí odkaz:
https://doaj.org/article/e6e21fe917fc41d197632859279b894c
Publikováno v:
Atherosclerosis. 292:1-9
Visceral fat accumulation has a marked impact on atherosclerotic cardiovascular diseases and metabolic syndrome clustering diabetes, dyslipidemia, and hypertension. Adiponectin, an adipocyte-derived circulating protein, is a representative adipocytok