Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Tohru Daikoku"'
Publikováno v:
IBRO Neuroscience Reports, Vol 14, Iss , Pp 447-452 (2023)
Stress-induced overactivation of glucocorticoid signaling may contribute to mental illness by inducing neuronal death and dysfunction. We previously reported that pretreatment with the plant flavonoid butein inhibits corticosterone (CORT)-induced apo
Externí odkaz:
https://doaj.org/article/8a1d44e03d554f47b3ef60a40468210a
Autor:
Hidetaka Sadanari, Masaya Takemoto, Tomoki Ishida, Hikaru Otagiri, Tohru Daikoku, Tsugiya Murayama, Shuichi Kusano
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Human phospholipid scramblase 1 (PLSCR1) is strongly expressed in response to interferon (IFN) treatment and viral infection, and it has been suggested to play an important role in IFN-dependent antiviral responses. In this study, we showed
Externí odkaz:
https://doaj.org/article/9891f004ea8d42bda5a127000e6d9cca
Autor:
Masanori Ohmoto, Yukina Shibuya, Shihori Taniguchi, Tomoki Nakade, Masaaki Nomura, Yuri Ikeda-Matsuo, Tohru Daikoku
Publikováno v:
IBRO Reports, Vol 8, Iss , Pp 82-90 (2020)
A functional understanding of the relationship between glucocorticoids and neuronal apoptosis induced by the production of reactive oxygen species (ROS) may lead to a novel strategy for the treatment or prevention of depression. Previous reports sugg
Externí odkaz:
https://doaj.org/article/fecde1ac4bf54c2da1257939e797d7a5
Autor:
Tohru Daikoku, Mineyuki Mizuguchi, Takayuki Obita, Takeshi Yokoyama, Yoshihiro Yoshida, Masaya Takemoto, Kimiyasu Shiraki
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 51, Iss 5, Pp 581-586 (2018)
Background: T-705 (favipiravir) is a potent inhibitor of RNA-dependent RNA polymerases of influenza viruses and no favipiravir-resistant virus has been isolated. Poliovirus RNA polymerase has been well characterized and isolation of resistant virus w
Externí odkaz:
https://doaj.org/article/fe371787875f47e6b9fb0c0dcb611317
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 3, Pp 281-284 (2014)
Abstract.: T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for pla
Externí odkaz:
https://doaj.org/article/54b82f1af69845c4a2a8577677ba76bc
Emergence of varicella-zoster virus resistance to acyclovir: epidemiology, prevention, and treatment
Publikováno v:
Expert Review of Anti-infective Therapy. 19:1415-1425
Introduction: Acyclovir has led to the development of successful systemic therapy for herpes simplex virus and varicella-zoster virus (VZV) infection, and the use of valacyclovir and famciclovir ha...
Autor:
Kimiyasu Shiraki, Tohru Daikoku
Publikováno v:
Pharmacology & Therapeutics
Favipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a cha
Publikováno v:
Antiviral research. 180
Amenamevir is a helicase-primase inhibitor of herpes simplex virus (HSV) and varicella-zoster virus (VZV) and is used for the treatment of herpes zoster in Japan. The half maximal effective concentrations (EC50s) of acyclovir and sorivudine for VZV i
Autor:
Tsugiya Murayama, Hidetaka Sadanari, Masayuki Ninomiya, Daiki Nema, Kazuhiro J. Fujimoto, Mamoru Koketsu, Masaya Takemoto, Tohru Daikoku
Publikováno v:
Antiviral Research. 154:10-16
A novel type of antiviral agent for human cytomegalovirus (HCMV) is required, because the appearance of ganciclovir (GCV) resistant viruses has been reported. Tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone) has been shown to suppress signific
Autor:
Tsugiya Murayama, Akimasa Itoh, Masaya Takemoto, Tohru Daikoku, Keiko Matsubara, Hidetaka Sadanari
Publikováno v:
Microbiology and Immunology. 62:341-347
Treatment of human embryonic lung fibroblast (HEL) cells with tricin (4', 5, 7-trihydroxy-3', 5'-dimethoxyflavone) following infection with human cytomegalovirus (HCMV) reportedly significantly suppresses HCMV replication. In the present work, the me