Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Tohru Mizushima"'
Autor:
Ken-ichiro Tanaka, Mikako Shimoda, Toshifumi Sugizaki, Maki Ikeda, Ayaka Takafuji, Masahiro Kawahara, Naoki Yamakawa, Tohru Mizushima
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract Although the exact pathogenesis of idiopathic pulmonary fibrosis (IPF) is still unknown, the transdifferentiation of fibroblasts into myofibroblasts and the production of extracellular matrix components such as collagen, triggered by alveola
Externí odkaz:
https://doaj.org/article/f17d177ac2104e76a42857c879eee87b
Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice
Autor:
Ken-ichiro Tanaka, Tomomi Niino, Tomoaki Ishihara, Ayaka Takafuji, Takahiro Takayama, Yuki Kanda, Toshifumi Sugizaki, Fumiya Tamura, Shota Kurotsu, Masahiro Kawahara, Tohru Mizushima
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for c
Externí odkaz:
https://doaj.org/article/e655d241e86147c782e24d9512684d35
Publikováno v:
Physiology. 38
Background & Aim: A nonsteroidal anti-inflammatory drugs (NSAIDs) exert their anti-inflammatory effects by inhibiting cyclooxygenase (COX), thereby reducing prostaglandin (PG) levels. However, PGs play a number of roles in the gastrointestinal tract,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdbea0f77fb1ec51d5ba7ff18c62f4c
https://doi.org/10.1152/physiol.2023.38.s1.5735040
https://doi.org/10.1152/physiol.2023.38.s1.5735040
Autor:
Ken-Ichiro Tanaka, Naoki Yamakawa, Yasunobu Yamashita, Teita Asano, Yuki Kanda, Ayaka Takafuji, Masahiro Kawahara, Mitsuko Takenaga, Yoshifumi Fukunishi, Tohru Mizushima
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The standard treatment for chronic obstructive pulmonary disease is a combination of anti-inflammatory drugs and bronchodilators. We recently found that mepenzolate bromide (MP), an antagonist for human muscarinic M3 receptor (hM3R), has both anti-in
Externí odkaz:
https://doaj.org/article/5b550f05b51d4e2cb8a9c89e57e463fe
Publikováno v:
FEMS Microbes. 3
A total of 1253 compounds approved as therapeutic drugs in Japan (Pharmaceuticals and Medical Devices Agency (PMDA)-approved compounds) were screened for their therapeutic effects against Staphylococcus aureus infection using the silkworm infection m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63160fcdfa9f3db3673fd341a5611a33
https://doi.org/10.1093/femsmc/xtac014
https://doi.org/10.1093/femsmc/xtac014
Autor:
Tohru Mizushima
Publikováno v:
Pharmaceuticals, Vol 3, Iss 5, Pp 1614-1636 (2010)
The anti-inflammatory action of non-steroidal anti-inflammatory drugs (NSAIDs) is mediated through their inhibitory effects on cyclooxygenase (COX) activity. On the other hand, NSAID use is often associated with gastrointestinal complications. The in
Externí odkaz:
https://doaj.org/article/68212cb61e8741d390674e6356a58531
Autor:
Tohru Mizushima, Masahiro Kawahara, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Ken Ichiro Tanaka
Publikováno v:
Life sciences. 288
Renal ischemia/reperfusion (I/R) injury is a major clinical problem because it can cause acute kidney injury (AKI) or lead to the transition from AKI to chronic kidney disease (CKD). Oxidative stress, which involves the production of reactive oxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d268ce8bccd491c8e82d3fba4ca9f16
https://pubmed.ncbi.nlm.nih.gov/34822794
https://pubmed.ncbi.nlm.nih.gov/34822794
Autor:
Ken Ichiro Tanaka, Teita Asano, Daisuke Kobayashi, Tohru Mizushima, Ayaka Takafuji, Yuuki Hino, Kaoru Mogushi, Toshifumi Sugizaki, Mikako Shimoda, Masahiro Kawahara
Publikováno v:
Cell Death Discovery, Vol 5, Iss 1, Pp 1-15 (2019)
Cell Death Discovery
Cell Death Discovery
Alveolar epithelial injury induced by reactive oxygen species (ROS) and abnormal collagen production by activated fibroblasts (myofibroblasts) is involved in the onset and exacerbation of idiopathic pulmonary fibrosis (IPF). Compared with alveolar ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40c0ae8917b06c32e9f4041a3110ad0
http://link.springer.com/article/10.1038/s41420-019-0226-y
http://link.springer.com/article/10.1038/s41420-019-0226-y
Autor:
Tatsuya Hoshino, Koichiro Suzuki, Takahide Matsushima, Naoki Yamakawa, Toshiharu Suzuki, Tohru Mizushima
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76306 (2013)
Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Aβ is generated by the secretase-mediated proteolysis of β-amyloid precursor protein (APP), and cleared by enzyme-mediated degradation and phagocytosi
Externí odkaz:
https://doaj.org/article/1b71a41dfba94657bf2dda69f5b3cc97
Autor:
Tadaaki Mashimo, Yoshifumi Fukunishi, Mitsuko Takenaga, Tohru Mizushima, Ken Ichiro Tanaka, Mitsuhito Wada, Teita Asano, Yuto Noda, Naoki Yamakawa
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
The adenosine A2B receptor is a critical protein in intestinal water secretion. In the present study, we screened compound libraries to identify inhibitors of the A2B receptor and evaluated their effect on adenosine-induced intestinal fluid secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08c7f167b758282f78ab44de08e6db2
https://doi.org/10.1038/s41598-020-60147-7
https://doi.org/10.1038/s41598-020-60147-7