Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Autor: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Publikováno v: eLife, Vol 12 (2024)

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate

Externí odkaz: https://doaj.org/article/15de117935204a21a8487997042e8094

Visually cued fear conditioning test for memory impairment related to cortical function

Autor: Kazuya Kuboyama, Yuki Shirakawa, Koji Kawada, Naoki Fujii, Daiki Ojima, Yasushi Kishimoto, Tohru Yamamoto, Maki K. Yamada

Publikováno v: Neuropsychopharmacology Reports, Vol 40, Iss 4, Pp 371-375 (2020)

Abstract Aim Fear conditioning tests are intended to elucidate a subject's ability to associate a conditioned stimulus with an aversive, unconditioned stimulus, such as footshock. Among these tests, a paradigm related to precise cortical functions wo

Externí odkaz: https://doaj.org/article/e8671a197b424b6d87d2d25e37221997

Dysfunction of axonal transport in normal-tension glaucoma: a biomarker of disease progression and a potential therapeutic target

Autor: Kazuyuki Hirooka, Tohru Yamamoto, Yoshiaki Kiuchi

Publikováno v: Neural Regeneration Research, Vol 16, Iss 3, Pp 506-507 (2021)

Externí odkaz: https://doaj.org/article/69a78230b10e45f696a9cd2e8701120c

Molecular mechanisms underlying activity-dependent ischemic tolerance in the brain

Autor: Hiroo Takahashi, Tohru Yamamoto, Akio Tsuboi

Publikováno v: Neuroscience research. 186

Ischemic stroke is one of the leading causes of death and disability worldwide. The inhibition of cerebral blood flow triggers intertwined pathological events, resulting in cell death and loss of brain function. Interestingly, animals pre-exposed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec4ee3a2b14c7a909f163a7714a4404
https://pubmed.ncbi.nlm.nih.gov/36244569

Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A

Autor: S M Khaledur, Rahman, Zahir, Hussain, Katsuya, Morito, Naoko, Takahashi, Mohammad Mamun, Sikder, Tamotsu, Tanaka, Ken-Ichi, Ohta, Masaki, Ueno, Hiroo, Takahashi, Tohru, Yamamoto, Makoto, Murakami, Toru, Uyama, Natsuo, Ueda

Publikováno v: Biochimica et biophysica acta. Molecular and cell biology of lipids. 1867(12)

N-Acyl-phosphatidylethanolamines (NAPEs), a minor class of membrane glycerophospholipids, accumulate along with their bioactive metabolites, N-acylethanolamines (NAEs) during ischemia. NAPEs can be formed through N-acylation of phosphatidylethanolami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afae9bcaefdb79c0f5429cb5b9b6ae6d
https://pubmed.ncbi.nlm.nih.gov/35988872