Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Tohru, Tanaka"'
Autor:
Takeru Akabane, Hiromori Sagae, Koen van Wijk, Shinichi Saitoh, Tomohiro Kimura, Satoshi Okano, Ken Kodama, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Michiaki Takagi, Osamu Nakajima
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Heme serves as a prosthetic group in hemoproteins, including subunits of the mammalian mitochondrial electron transfer chain. The first enzyme in vertebrate heme biosynthesis, 5-aminolevulinic acid synthase 1 (ALAS1), is ubiquitously express
Externí odkaz:
https://doaj.org/article/53a9e544ddb14ada9afd52a964b9cb31
Autor:
Hiroki Koyasu, Shigeo Horie, Kazuhito Matsushita, Takeshi Ashizawa, Satoru Muto, Shuji Isotani, Tohru Tanaka, Motowo Nakajima, Akira Tsujimura
Publikováno v:
The World Journal of Men's Health, Vol 40, Iss 3, Pp 456-464 (2022)
Purpose:Purpose: As the concept of late-onset hypogonadism (LOH) has gained increased attention, the treatment of eugonadal patients with LOH symptom has become a clinical problem. Previous studies have shown the possible benefits of 5-ami-nolevulini
Externí odkaz:
https://doaj.org/article/e3f20fba2aff4ee1859d1702fd0dc7ae
Autor:
Chi Liu, Masayuki Fujino, Shuoji Zhu, Yoshitaka Isaka, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Ping Zhu, Xiao‐Kang Li
Publikováno v:
FEBS Open Bio, Vol 9, Iss 11, Pp 1928-1938 (2019)
Cyclosporin A (CsA) is a common immunosuppressant, but its use is limited as it can cause chronic kidney injury. Oxidative stress and apoptosis play a key role in CsA‐induced nephrotoxicity. This study investigated the protective effect of 5‐amin
Externí odkaz:
https://doaj.org/article/6ae9f32a87ff435f9ec75c431f68c8ae
Autor:
Yuta Sugiyama, Yukari Hiraiwa, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura
Publikováno v:
BMC Immunology, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background Macrophages are crucial players in a variety of inflammatory responses to environmental cues. However, it has been widely reported that macrophages cause chronic inflammation and are involved in a variety of diseases, such as obes
Externí odkaz:
https://doaj.org/article/beeb1bb96d1f4dca96b3de0ff843e91f
Autor:
Tomohiro Osaki, Kengo Gonda, Yusuke Murahata, Yuji Sunden, Takao Amaha, Narumi Kunisue, Kiwamu Takahashi, Masahiro Ishizuka, Tohru Tanaka, Liming Li, Inoru Yokoe, Masamichi Yamashita, Kazuo Azuma, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa, Yoshiharu Okamoto
Publikováno v:
Journal of Feline Medicine and Surgery Open Reports, Vol 6 (2020)
Case summary The present study describes the case of a feline meningioma that was detected using 5-aminolaevulinic acid hydrochloride (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence at surgery. An extra-axial mass in the temporoparietal region
Externí odkaz:
https://doaj.org/article/33da7116ada0468da18724575321e130
Autor:
Shizuka Hirose, Norikazu Isoda, Loc Tan Huynh, Taksoo Kim, Keiichiro Yoshimoto, Tohru Tanaka, Kenjiro Inui, Takahiro Hiono, Yoshihiro Sakoda
Publikováno v:
Pathogens, Vol 11, Iss 2, p 164 (2022)
The inhibitory effects of 5-aminolevulinic acid phosphate (5-ALA), an important amino acid for energy production in the host, against viral infections were previously reported. Here, the antiviral effects of 5-ALA against classical swine fever virus
Externí odkaz:
https://doaj.org/article/4a10ee76eea74aac8741820782121f4b
Autor:
Kei Saito, Tohru Fujiwara, Urara Ota, Shunsuke Hatta, Satoshi Ichikawa, Masahiro Kobayashi, Yoko Okitsu, Noriko Fukuhara, Yasushi Onishi, Masahiro Ishizuka, Tohru Tanaka, Hideo Harigae
Publikováno v:
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 105-111 (2017)
5-Aminolevulinic acid (ALA) is a precursor for the biosynthesis of porphyrins and heme. Although the oral administration of ALA has been widely applied in clinical settings, the dynamics of its absorption, metabolism, and excretion within enterocytes
Externí odkaz:
https://doaj.org/article/4f31af3ee5894d1388c85f8eabbf44f2
Autor:
Chikako Fujii, Kazutoshi Miyashita, Masanori Mitsuishi, Masaaki Sato, Kentaro Fujii, Hiroyuki Inoue, Aika Hagiwara, Sho Endo, Asuka Uto, Masaki Ryuzaki, Motowo Nakajima, Tohru Tanaka, Masanori Tamaki, Ayako Muraki, Toshihide Kawai, Hiroshi Itoh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Recently, sarcopenia has attracted attention as therapeutic target because it constitutes a risk factor for metabolic and cardiovascular diseases. We focused 5-aminolevulinic acid (ALA) which act as electron carriers in the mitochondrial ele
Externí odkaz:
https://doaj.org/article/3bbd0cbf26ea4990bafd6f92fe58cde9
Autor:
Peter R. Rehani, Hanaa Iftikhar, Motowo Nakajima, Tohru Tanaka, Zaid Jabbar, Riyadh N. Rehani
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-
Externí odkaz:
https://doaj.org/article/e2d8aca655fe4c7db928f82d203b2f38
Autor:
Shinichi Saitoh, Satoshi Okano, Hidekazu Nohara, Hiroshi Nakano, Nobuyuki Shirasawa, Akira Naito, Masayuki Yamamoto, Vincent P Kelly, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, Osamu Nakajima
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189593 (2018)
In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, several cohort studies have
Externí odkaz:
https://doaj.org/article/efc895c4df474e859b68c6e39f1d1f91