Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Tohru, Kozasa"'
Autor:
Tatsuhiko Kodama, Shin Yoneya, Hiroto Kuroda, Motoyoshi Baba, Kazuyuki Masuda, Takao Hamakubo, Tohru Kozasa
Publikováno v:
Pharmaceuticals, Vol 4, Iss 3, Pp 524-550 (2011)
Many signaling molecules involved in G protein-mediated signal transduction, which are present in the lipid rafts and believed to be controlled spatially and temporally, influence the potency and efficacy of neurotransmitter receptors and transporter
Externí odkaz:
https://doaj.org/article/abcfa7db685747e591b262f6220b30d1
Autor:
Yuki Hoshino, Kazuya Mori, Tatsuo Shinozuka, Hayato Kohno, Etienne Kochole Obossou, Iwao Sakakibara, Keiko Tonooka, Yukiko Ishibasi, Yasuo Shikamoto, Maho Taguchi, Tohru Kozasa
Manuka honey (MkH), derived from New Zealand manuka tree (Leptospermum scoparium), is considered a therapeutic agent owing to its antibacterial, antioxidant, antifungal, antiviral, anti-inflammatory, and wound healing activities. In this study, the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fff7defcbc2b094962281140c81659
Autor:
Tohru Kozasa
G protein-mediated signal transduction is a fundamental mechanism of cell communication, involved in neurotransmission, responses to hormones, chemical sensation, cell growth, and cell differentiation.1,2,3 These signal transducers receive informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0473b8c7f76ef7eff49387a7773b971
https://doi.org/10.1201/9780429129360-2
https://doi.org/10.1201/9780429129360-2
Autor:
Aiko Ito, Yasutake Saeki, Daisuke Umeki, Motohito Goto, Yoshinori Sahara, Tohru Kozasa, Kouichi Shiozawa, Tadashi Okamura, Yuka Yagisawa, Yoshiki Ohnuki, Rieko Yanobu-Takanashi, Naoya Kawamura, Yukiko Shimizu, Yasumasa Mototani, Megumi Nariyama, Kenji Suita, Satoshi Okumura
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:937-947
The G protein-regulated inducer of neurite growth (GRIN) family has three isoforms (GRIN1-3), which bind to the Gαi/o subfamily of G protein that mediate signal processing via G protein-coupled receptors (GPCRs). Here, we show that GRIN3 is involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1eb3384e2ddf97a72e86c84cb724a5
https://doi.org/10.1007/s00424-018-2124-1
https://doi.org/10.1007/s00424-018-2124-1
Autor:
Jun-Ichi Kitakami, Takao Hamakubo, Tohru Kozasa, Tatsuhiko Kodama, Kazuyuki Masuda, Sigeo Ihara
Publikováno v:
The FASEB Journal. 31:910-919
Cell migration to chemoattractants is critically important in both normal physiology and the pathogenesis of many diseases. In GPCR-mediated chemotaxis, GPCRs transduce the gradient of an extracellular chemotactic ligand into intracellular responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f79fdc3d7b0022a72e00d036ff64a1
https://doi.org/10.1096/fj.201601102r
https://doi.org/10.1096/fj.201601102r
Autor:
Maulik Patel, Takao Hamakubo, Andrei V. Karginov, Takeharu Kawano, Nobuchika Suzuki, Tohru Kozasa
Publikováno v:
Molecular Pharmacology. 86:252-262
Gastrin-releasing peptide receptor (GRPR) is ectopically expressed in over 60% of colon cancers. GRPR expression has been correlated with increased colon cancer cell migration. However, the signaling pathway by which GRPR activation leads to increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d400e7e50d49aad9c6c1219b6a87f4c8
https://doi.org/10.1124/mol.114.093914
https://doi.org/10.1124/mol.114.093914
Autor:
Alexandra V. Andreeva, Xiaoping Du, David J. Visintine, Jaehyung Cho, Richard D. Minshall, Farnaz R. Bakhshi, Luiza Rusu, Osamu Kusano-Arai, Kyungho Kim, Nobuchika Suzuki, Sandra L. Haberichter, Aleksandra Stojanovic-Terpo, Takao Hamakubo, Guoquan Liu, Olga Chernaya, Hiroko Iwanari, Stephen M. Vogel, Tohru Kozasa
Publikováno v:
Blood. 123:442-450
von Willebrand factor (vWF) secretion by endothelial cells (ECs) is essential for hemostasis and thrombosis; however, the molecular mechanisms are poorly understood. Interestingly, we observed increased bleeding in EC-Gα13(-/-);Gα12(-/-) mice that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51feff594cf765a571724d0b6429ee55
https://doi.org/10.1182/blood-2013-03-489351
https://doi.org/10.1182/blood-2013-03-489351
Autor:
Tohru Kozasa, Mark R. Nance, Valerie M. Tesmer, Barry Kreutz, John J.G. Tesmer, Rachel Sterne-Marr
Publikováno v:
Structure. 21(3):438-448
The heterotrimeric G protein Gαq is a key regulator of blood pressure, and excess Gαq signaling leads to hypertension. A specific inhibitor of Gαq is the GTPase activating protein (GAP) known as regulator of G protein signaling 2 (RGS2). The molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d905e0cf702036ad17a29f8719abdb58
Autor:
Kazuyuki, Masuda, Jun-Ichi, Kitakami, Tohru, Kozasa, Tatsuhiko, Kodama, Sigeo, Ihara, Takao, Hamakubo
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(3)
Cell migration to chemoattractants is critically important in both normal physiology and the pathogenesis of many diseases. In GPCR-mediated chemotaxis, GPCRs transduce the gradient of an extracellular chemotactic ligand into intracellular responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a9bc0e80a845299dcceaf91c00f2c44
https://pubmed.ncbi.nlm.nih.gov/27881485
https://pubmed.ncbi.nlm.nih.gov/27881485
Autor:
Chen Wang, Dario R. Alessi, Eeva Sommer, Melvin I. Simon, Dianqing Wu, Jiyong Wang, Stefan Offermanns, Tohru Kozasa, Xiaoqing Gan, Srinivasa M. Srinivasula
Publikováno v:
Nature cell biology
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates AGC protein kinases including protein kinase C (PKC) and regulates cellular functions such as cell migration. However, its regulation remains poorly understood. Here we show that lysopho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41ad46a8c75ee88c24915562e9ba901
http://europepmc.org/articles/PMC3389271
http://europepmc.org/articles/PMC3389271