Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Tohru, Ikuta"'
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0144561 (2016)
Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP signaling, but virtually nothing is known about its hematologic effects. We reported for the first time that cGMP signaling induces human γ-globin gene expressio
Externí odkaz:
https://doaj.org/article/9e054fd6a8db418682fa4a5b418f217c
Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells.
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99363 (2014)
Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD
Externí odkaz:
https://doaj.org/article/c98d56af2b024a87b39552c62c5df6da
Publikováno v:
Journal of Blood Medicine
Tohru Ikuta,1 Hassan Sellak,1 Si-Yang Liu,2 Nadine Odo1 1Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA; 2Department of Biochemistry and Molecular Biology, Medical College of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963938e7db6f9e83838b53caea8f3a66
https://pubmed.ncbi.nlm.nih.gov/29950916
https://pubmed.ncbi.nlm.nih.gov/29950916
Autor:
Teruko Nakazawa, Ryoki Takahashi, Tohru Ikuta, Takayasu Noguchi, Yoko Mizoguchi, Tadashi Shimoyama
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2018 (2018)
BioMed Research International, Vol 2018 (2018)
Despite the recent development of biological modifiers for inflammatory bowel diseases (IBD), there continues to be considerable interest in fermented medicines because of its negligible adverse effects. We previously showed that the synbiotic Gut Wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02f41ff836ff9f452e05d8536108d41
http://europepmc.org/articles/PMC5971273
http://europepmc.org/articles/PMC5971273
Publikováno v:
Journal of Blood Medicine. 2013, Vol. 4, p149-159. 11p.
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0144561 (2016)
PLoS ONE
PLoS ONE
Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP signaling, but virtually nothing is known about its hematologic effects. We reported for the first time that cGMP signaling induces human γ-globin gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc335e319ac3ae3644024ae7b69dcf7
http://europepmc.org/articles/PMC4699757?pdf=render
http://europepmc.org/articles/PMC4699757?pdf=render
Autor:
Tohru Ikuta, Nadine Odo, Abdullah Kutlar, Diana Gutsaeva, C. Alvin Head, James B. Parkerson, Adekunle Adekile, Betsy Clair, Shobha Yerigenahally
Publikováno v:
Blood Cells, Molecules, and Diseases. 47:235-242
Although reduction in leukocyte counts following hydroxyurea therapy in sickle cell disease (SCD) predicts fetal hemoglobin (HbF) response, the underlying mechanism remains unknown. We previously reported that leukocyte counts are regulated by granul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8548dd9b9193609807584f34c17429ea
https://doi.org/10.1016/j.bcmd.2011.08.005
https://doi.org/10.1016/j.bcmd.2011.08.005
Autor:
Paolo Moi, M. Giuseppina Loi, M. Giuseppina Marini, M. Serafina Ristaldi, Susanna Porcu, Antonio Cao, Loredana Porcu, Isadora Asunis, Tohru Ikuta
Publikováno v:
British Journal of Haematology. 149:748-758
KLF1/EKLF and related Krueppel-like factors (KLFs) are variably implicated in the regulation of the HBB-like globin genes. Prompted by the observation that four KLF sites are distributed in the human alpha-globin gene (HBA) promoter, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e97f326ac93e97b375796d101fc730
https://doi.org/10.1111/j.1365-2141.2010.08130.x
https://doi.org/10.1111/j.1365-2141.2010.08130.x
Autor:
Yuichi Kuroyanagi, Nicola Conran, Tohru Ikuta, Carla F. Franco-Penteado, Fernando Ferreira Costa, Maria Domenica Cappellini, S. Ausenda, Lakiea Bailey
Publikováno v:
British Journal of Haematology. 138:382-395
The present study found that the cyclic adenosine monophosphate (cAMP)-dependent pathway efficiently induced gamma-globin expression in adult erythroblasts, and this pathway plays a role in gamma-globin gene (HBG) expression in beta-thalassaemia. Exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::103b5f39f1cae3629745b2081d78dae8
https://doi.org/10.1111/j.1365-2141.2007.06673.x
https://doi.org/10.1111/j.1365-2141.2007.06673.x
Autor:
Kenjiro Muta, S. Ausenda, Yuji Kaneko, Maria Domenica Cappellini, Yuichi Kuroyanagi, Tohru Ikuta, Buem Seek Park, Paolo Moi
Publikováno v:
Biochemical and Biophysical Research Communications. 344:1038-1047
Our previous studies demonstrated roles of cyclic nucleotides in gamma-globin gene expression. We recently found that, upon activation of the cAMP pathway, expression of the gamma-globin gene is inhibited in K562 cells but induced in adult erythrobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043ada028dc41c4410d8bd9b4b8cbc54
https://doi.org/10.1016/j.bbrc.2006.03.203
https://doi.org/10.1016/j.bbrc.2006.03.203