Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Toh-Seok Kam"'
Autor:
Mohammed Zuhair Al-Hayali, Choy-Eng Nge, Kuan Hon Lim, Hilary M. Collins, Toh-Seok Kam, Tracey D. Bradshaw
Publikováno v:
Molecules, Vol 29, Iss 11, p 2654 (2024)
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbo
Externí odkaz:
https://doaj.org/article/d5b3d51d6b3d4a9195e365bb4d7c2698
Autor:
Haneen Abuzaid, Salah Abdelrazig, Lenny Ferreira, Hilary M. Collins, Dong-Hyun Kim, Kuan-Hon Lim, Toh-Seok Kam, Neil R. Thomas, Lyudmila Turyanska, Tracey D. Bradshaw
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 2012-2012 (2023)
Externí odkaz:
https://doaj.org/article/9b131eac926943a483f5c1ebd851ad6d
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and mechanism of action of
Externí odkaz:
https://doaj.org/article/e057621f1adb4b8980ea362a8c28884b
Autor:
Christopher J. Smedley, Paul A. Stanley, Mohannad E. Qazzaz, Andrea E. Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S. Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J. Smith, Hendrika M. Duivenvoorden, Belinda S. Parker, Tracey D. Bradshaw, Michel O. Steinmetz, John E. Moses
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly d
Externí odkaz:
https://doaj.org/article/cd703e3a1db842d9bf536015c27b64dc
Autor:
Haneen Abuzaid, Salah Abdelrazig, Lenny Ferreira, Hilary M. Collins, Dong-Hyun Kim, Kuan-Hon Lim, Toh-Seok Kam, Lyudmila Turyanska, Tracey D. Bradshaw
Publikováno v:
ACS Omega. 7:21473-21482
The O-acetyl (or acetate) derivative of the Aspidosperma alkaloid Jerantinine A (JAa) elicits anti-tumor activity against cancer cell lines including mammary carcinoma cell lines irrespective of receptor status (0.14 < GI 50 < 0.38 ?M), targeting mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64866e0e5ce8a09d5d218cf7f55112c
https://doi.org/10.1021/acsomega.2c00997
https://doi.org/10.1021/acsomega.2c00997
Autor:
Yuecheng Wu, Zhiqiang Ma, Yubing Pang, Cheng Wang, Nanping Zhang, Ting Fan, Rui Yang, Pengquan Chen, Xue-Tao Xu, Ying Li, Toh-Seok Kam, Huanfeng Jiang
Publikováno v:
Angewandte Chemie. 133:27184-27191
A divergent synthesis of skeletally distinct arboridinine and arborisidine was achieved. The central divergent strategy was inspired by the divergent biosynthetic cyclization mode of arboridinine and arborisidine and their hidden topological connecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a61d36fccc76bdffdd810e5c8b298fb
https://doi.org/10.1002/ange.202110149
https://doi.org/10.1002/ange.202110149
Publikováno v:
Journal of Natural Products. 84:1524-1533
A new linearly fused macroline-sarpagine bisindole, angustilongine M (1), was isolated from the methanolic extract of Alstonia penangiana. The structure of the alkaloid was elucidated based on analysis of the spectroscopic data, and its biological ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddafdb4bc56d0099e57a5a53087539b0
https://doi.org/10.1021/acs.jnatprod.1c00013
https://doi.org/10.1021/acs.jnatprod.1c00013
Schwarzinicines A–G, 1,4-Diarylbutanoid–Phenethylamine Conjugates from the Leaves of Ficus schwarzii
Autor:
Kuan-Hon Lim, Fong-Kai Lee, Kien-Thai Yong, Kang Nee Ting, Toh-Seok Kam, Premanand Krishnan, Yun-Yee Low, Veronica Alicia Yap
Publikováno v:
Journal of Natural Products. 83:152-158
Schwarzinicines A–G (1–7), representing the first examples of 1,4-diarylbutanoid–phenethylamine conjugates, were isolated from the leaves of Ficus schwarzii. The structures of these compounds were determined by detailed analysis of their MS, 1D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::982fbdb5fc34b0808f259ae9ef10e5bc
https://doi.org/10.1021/acs.jnatprod.9b01160
https://doi.org/10.1021/acs.jnatprod.9b01160
Autor:
Chun Hoe Tan, Dawn Su Yin Sim, Siew Huah Lim, Taznim Begam Mohd Mohidin, Gokula Mohan, Yun Yee Low, Toh Seok Kam, Kae Shin Sim
Publikováno v:
Planta medica. 88(14)
Two iboga-vobasine bisindoles, 16′-decarbomethoxyvoacamine (1) and its 19,20-dihydro derivative, 16′-decarbomethoxydihydrovoacamine (2) from Tabernaemontana corymbosa exhibited potent cytotoxicity against the human colorectal adenocarcinoma HT-29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f8d5e1e4dccae685d69349643520dc
https://pubmed.ncbi.nlm.nih.gov/35100653
https://pubmed.ncbi.nlm.nih.gov/35100653
Publikováno v:
Phytochemistry. 203:113384
Thirteen indole alkaloids comprising six vobasine/sarpagine, one vincamine, two voaphylline, two tacaman, one iboga, and one corynantheine alkaloid, were isolated from the leaf extract of Tabernaemontana corymbosa (sample from Taiping, Perak, Malaysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64344835f658180303fa534113acad54
https://doi.org/10.1016/j.phytochem.2022.113384
https://doi.org/10.1016/j.phytochem.2022.113384