An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis

Autor: Hino, Tomohiro, Omura, Satoshi N., Nakagawa, Ryoya, Togashi, Tomoki, Takeda, Satoru N., Hiramoto, Takafumi, Tasaka, Satoshi, Hirano, Hisato, Tokuyama, Takeshi, Uosaki, Hideki, Ishiguro, Soh, Kagieva, Madina, Yamano, Hiroyuki, Ozaki, Yuki, Motooka, Daisuke, Mori, Hideto, Kirita, Yuhei, Kise, Yoshiaki, Itoh, Yuzuru, Matoba, Satoaki, Aburatani, Hiroyuki, Yachie, Nozomu, Karvelis, Tautvydas, Siksnys, Virginijus, Ohmori, Tsukasa, Hoshino, Atsushi, Nureki, Osamu

Publikováno v: In Cell 26 October 2023 186(22):4920-4935

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Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice.

Autor: Togashi T; Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan (T.T., E.M.).; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.)., Baatartsogt N; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.)., Nagao Y; Center for Experimental Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan. (Y.N.)., Kashiwakura Y; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.).; Center for Gene Therapy Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan. (Y.K., M.H., T.O.)., Hayakawa M; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.).; Center for Gene Therapy Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan. (Y.K., M.H., T.O.)., Hiramoto T; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.)., Fujiwara T; Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan (T.F.).; Department of Cardiovascular Medicine, The University of Tokyo Hospital, Japan (T.F.)., Morishita E; Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan (T.T., E.M.)., Nureki O; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan (O.N.)., Ohmori T; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.).; Center for Gene Therapy Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan. (Y.K., M.H., T.O.).

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.