Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Autor: Lee, Soojung, Toft, Nicolai Juel, Axelsen, Trine Veje, Espejo, Maria Sofia, Pedersen, Tina Myhre, Mele, Marco, Pedersen, Helene Lintrup, Balling, Eva, Johansen, Tonje, Burton, Mark, Thomassen, Mads, Vahl, Pernille, Christiansen, Peer Michael, Boedtkjer, Ebbe

Publikováno v: Lee, S, Toft, N J, Axelsen, T V, Espejo, M S, Pedersen, T M, Mele, M, Pedersen, H L, Balling, E, Johansen, T, Burton, M, Thomassen, M, Vahl, P, Christiansen, P M & Boedtkjer, E 2023, ' Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer ', Breast Cancer Research, vol. 25, 46 . https://doi.org/10.1186/s13058-023-01644-1

Background Carbonic anhydrases catalyze CO2/HCO3– buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal cell funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbae1ffcaa764a161bf66160eeb6939
https://doi.org/10.1186/s13058-023-01644-1