X-Ray analysis of d(CGCGAATTXGCG) 2 containing a 2′-deoxy- N4-methoxycytosine residue at X: a characteristic pattern of sugar puckers in the crystalline state of the Dickerson–Drew type DNA dodecamers

Autor: Tofazzal Hossain, M, Kondo, Jiro, Ueno, Yoshihito, Matsuda, Akira, Takénaka, Akio ^*

Publikováno v: In Biophysical Chemistry 2002 95(1):69-77

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A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro.

Autor: Zhang H; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China., Yang Y; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China., Li J; Shenzhen Laboratory of Human Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, University City of Shenzhen, Shenzhen, China., Wang M; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China., Saravanan KM; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China., Wei J; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China., Tze-Yang Ng J; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Tofazzal Hossain M; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.; University of Chinese Academy of Sciences, Shijingshan District, Beijing, China., Liu M; Shenzhen Laboratory of Human Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, University City of Shenzhen, Shenzhen, China., Zhang H; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China., Ren X; Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China., Pan Y; Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America., Peng Y; Department of Pathology, School of Medicine, Shenzhen University, Shenzhen, China., Shi Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China., Wan X; Shenzhen Laboratory of Human Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, University City of Shenzhen, Shenzhen, China., Liu Y; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China., Wei Y; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2020 Dec 31; Vol. 16 (12), pp. e1008489. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).