Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry.

Autor: Sarott RC; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States., You I; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States., Li YD; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, United States.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, United States., Toenjes ST; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States., Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Seo P; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States., Ordonez M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Harvard University, Boston, Massachusetts 02215, United States., Byun WS; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States., Hassan MM; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States., Wachter F; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Department of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Harvard University, Boston, Massachusetts 02215, United States., Chouchani ET; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States., Słabicki M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, United States., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, United States.; Howard Hughes Medical Institute, Boston, Massachusetts 02115, United States., Hinshaw SM; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States., Gray NS; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Oct 11; Vol. 145 (40), pp. 21937-21944. Date of Electronic Publication: 2023 Sep 28.

Controlling Ibrutinib's Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity.

Autor: Toenjes ST; Department of Chemistry and Biochemistry and Donald P. Shiley BioScience Center, San Diego State University, San Diego, California 92182-1030, United States., Heydari BS; Department of Chemistry and Biochemistry and Donald P. Shiley BioScience Center, San Diego State University, San Diego, California 92182-1030, United States., Albright ST; Department of Chemistry and Biochemistry and Donald P. Shiley BioScience Center, San Diego State University, San Diego, California 92182-1030, United States., Hazin R; Department of Chemistry and Biochemistry and Donald P. Shiley BioScience Center, San Diego State University, San Diego, California 92182-1030, United States., Ortiz MA; Department of Chemistry and Biochemistry and Donald P. Shiley BioScience Center, San Diego State University, San Diego, California 92182-1030, United States., Piedrafita FJ; Department of Chemistry and Biochemistry and Donald P. Shiley BioScience Center, San Diego State University, San Diego, California 92182-1030, United States., Gustafson JL; Department of Chemistry and Biochemistry and Donald P. Shiley BioScience Center, San Diego State University, San Diego, California 92182-1030, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Feb 14; Vol. 14 (3), pp. 305-311. Date of Electronic Publication: 2023 Feb 14 (Print Publication: 2023).

Leveraging conformational control about a potential atropisomeric axis as a strategy in medical chemistry.

Autor: Toenjes ST; Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, USA., Basilaia M; Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, USA., Gustafson JL; Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, USA.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2021 Mar; Vol. 13 (5), pp. 443-446. Date of Electronic Publication: 2021 Jan 21.

Catalytic Atroposelective Synthesis of N -Aryl Quinoid Compounds.

Autor: Vaidya SD; Department of Chemistry and Biochemistry , San Diego State University , 5500 Campanile Drive , San Diego , California 92182-1030 , United States., Toenjes ST; Department of Chemistry and Biochemistry , San Diego State University , 5500 Campanile Drive , San Diego , California 92182-1030 , United States., Yamamoto N; Department of Chemistry and Biochemistry , San Diego State University , 5500 Campanile Drive , San Diego , California 92182-1030 , United States., Maddox SM; Department of Chemistry and Biochemistry , San Diego State University , 5500 Campanile Drive , San Diego , California 92182-1030 , United States., Gustafson JL; Department of Chemistry and Biochemistry , San Diego State University , 5500 Campanile Drive , San Diego , California 92182-1030 , United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2020 Feb 05; Vol. 142 (5), pp. 2198-2203. Date of Electronic Publication: 2020 Jan 28.

Towards a Catalytic Atroposelective Synthesis of Diaryl Ethers via C( sp ² )-H Alkylation Using Nitroalkanes.

Autor: Dinh AN; Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1030., Noorbehesht RR; Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1030., Toenjes ST; Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1030., Jackson AC; Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1030., Saputra MA; Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1030., Maddox SM; Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1030., Gustafson JL; Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1030.

Publikováno v: Synlett : accounts and rapid communications in synthetic organic chemistry [Synlett] 2018 Oct; Vol. 29 (16), pp. 2155-2160. Date of Electronic Publication: 2018 Jul 31.