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Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy

BACKGROUND: Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin-1β (IL-1β), activated by the NLRP3 inflammasome, compromises cardiac function. Whether or not deleting Nlrp3 would prevent ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::c88bcab0c4befc738bf93eccfac9fe94
http://edoc.mdc-berlin.de/20902/7/20902suppl.zip

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Akademický článek

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Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis

Autor: Rodrigues, A.F., Todiras, M., Qadri, F., Campagnole-Santos, M.J., Alenina, N., Bader, M.

In spite of the fact that the modulatory effects of angiotensin II (Ang II) on the sympathetic nerve activity to targeted organs involved in blood pressure (BP) regulation is well acknowledged, the local production of this peptide in the brain and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::c313037dd2ba453ac4a8bc5e99ae3e0d
http://edoc.mdc-berlin.de/20298/1/20298oa.pdf

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Phenylalanine-hydroxylase contributes to serotonin synthesis in mice

Autor: Mordhorst, A., Dhandapani, P., Matthes, S., Mosienko, V., Rothe, M., Todiras, M., Self, J., Schunck, W.H., Schütz, A., Bader, M., Alenina, N.

Serotonin is an important signaling molecule in the periphery and in the brain. The hydroxylation of tryptophan is the first and rate‐limiting step of its synthesis. In most vertebrates, two enzymes have been described to catalyze this step, trypto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::caa9b4ac5110b7d4c72d2173e85a71c9
http://edoc.mdc-berlin.de/20219/1/20219oa.pdf

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Angiotensin‐II receptor type Ia does not contribute to cardiac atrophy following high‐thoracic spinal cord injury in mice

Autor: Järve, A., Qadri, F., Todiras, M., Schmolke, S., Bader, M.

NEW FINDINGS: What is the central question of this study? Spinal cord injury leads to cardiac atrophy and the role of the renin-angiotensin system with angiotensin II acting via its receptor AT1a in this effect has not been previously explored. What

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::cb8d752f57bf55b74cf173ff9f6b90a5
http://edoc.mdc-berlin.de/19046/1/19046oa.pdf

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The absence of serotonin in the brain alters acute stress responsiveness by interfering with the genomic function of the glucocorticoid receptors

Autor: Sbrini, G., Brivio, P., Peeva, P.M., Todiras, M., Bader, M., Alenina, N., Calabrese, F.

Alterations in serotonergic transmission have been related to a major predisposition to develop psychiatric pathologies, such as depression. We took advantage of tryptophan hydroxylase (TPH) 2 deficient rats, characterized by a complete absence of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::a1b489c15351a0a813d32cdfa3677c37
http://edoc.mdc-berlin.de/19068/1/19068oa.pdf

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Serum amyloid A1 mediates myotube atrophy via Toll-like receptors

Autor: Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C., Fielitz, J.

Background: Critically ill patients frequently develop muscle atrophy and weakness in the intensive-care-unit setting [intensive care unit-acquired weakness (ICUAW)]. Sepsis, systemic inflammation, and acute-phase response are major risk factors. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::c36b2aa2dc6005e30c53b38958826929
http://edoc.mdc-berlin.de/18401/1/18401oa.pdf

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