Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Todd Wisialowski"'
Autor:
Emmanuel Boulay, Loïs S. Miraucourt, Michael K. Pugsley, Matthew M. Abernathy, Ray Chui, Jill Dalton, Marjorie Demers, Noel Dybdal, Elissa Gazaille, Andrea Greiter-Wilke, Peter Hoffmann, Hai Huang, Carrie LaDuke, Kevin Norton, Jennifer B. Pierson, Isabelle Reeves, Brian Roche, Eric I. Rossman, Albert E. Schultze, Hai-Ming Tang, Todd Wisialowski, Simon Authier
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 121:107266
Autor:
Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary Gintant, James Willard, Christine Garnett, Matthew Skinner, Hugo M Vargas, Todd Wisialowski, Michael K Pugsley
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 187(1)
The content of this article derives from a Health and Environmental Sciences Institute (HESI) consortium with a focus to improve cardiac safety during drug development. A detailed literature review was conducted to evaluate the concordance between no
Autor:
Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman
Publikováno v:
Clinical Pharmacology and Therapeutics
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide. In use for over 15 years
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 119:107208
Compound-mediated locomotion changes, conducted via open field infrared photobeam breaks, are an important common component of neurological assessments conducted in safety pharmacology studies. In addition to open field locomotor activity assessments
Autor:
Adam P. Hill, Zhen Song, Haibo Ni, Norman Stockbridge, David G. Strauss, Jamie I. Vandenberg, Todd Wisialowski, Mikiko Nakamura, Takashi Yoshinaga, Godfrey L. Smith, Jill Steidl‐Nichols, Mark Holbrook, Stefano Severi, Pierre Morissette, Derek J. Leishman, Colleen E. Clancy, Gary R. Mirams, Andrea Greiter-Wilke, Andrew G. Edwards, Xiaomei Han, Zhihua Li, Flora Musuamba Tshinanu, Stefano Morotti, Stephane Nave, Aaron Fullerton, Bradley J. Ridder, Zhilin Qu, Michelangelo Paci, Alfonso Bueno-Orovio, Janell E. Chen, Thomas Singer, Peter R. Kowey, Liudmila Polonchuk, Eric A. Sobie, Blanca Rodriguez, Randall L. Rasmusson, Elisa Passini, Eleonora Grandi, Ken Wang, Michael Liu, Bruce P. Damiano, Xin Zhou
Publikováno v:
Clinical pharmacology and therapeutics, vol 107, iss 1
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
This white paper presents principles for validating proarrhythmia risk prediction models for regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/US Food and
Autor:
Eric D, Watt, Tiffany, Lee, Shuyun Lily, Feng, Peter, Kilfoil, David, Ackley, Christopher, Keefer, Todd, Wisialowski, Stephen, Jenkinson
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 118:107213
The use of high throughput patch clamp profiling to determine mixed ion channel-mediated arrhythmia risk was assessed using profiling data generated using proprietary internal and clinical reference compounds. We define the reproducibility of the pla
Autor:
Gregory S. Friedrichs, David G. Strauss, Ariane Menard, Jill Steidl-Nichols, Jean-Michel Guillon, Nicolas Gendron-Parra, Simon Authier, Jean-Pierre Valentin, Ray W. Chui, Jennifer B. Pierson, Michael K. Pugsley, Eric I. Rossman, Todd Wisialowski, Matthew M. Abernathy, Emmanuel Boulay, John Koerner, Andrea Greiter-Wilke, Eric Troncy
Publikováno v:
International Journal of Toxicology. 38:23-32
Introduction: Based on the ICH S7B and E14 guidance documents, QT interval (QTc) is used as the primary in vivo biomarker to assess the risk of drug-induced torsades de pointes (TdP). Clinical and nonclinical data suggest that drugs that prolong the
Autor:
John Koerner, Michael K. Pugsley, William S. Redfern, Ray W. Chui, Jill A. Dalton, Malar Pannirselvam, Matthew M. Abernathy, C Michael Foley, Simon Authier, Gregory S. Friedrichs, Jean-Pierre Valentin, Vijay Urmaliya, Mary Jeanne Kallman, Todd Wisialowski, Tanja S. Zabka, Krystle Correll
Publikováno v:
International journal of toxicology. 39(4)
Introduction: The Safety Pharmacology Society (SPS) conducted a membership survey to examine industry practices related mainly to cardiovascular (CV) safety pharmacology (SP). Methods: Questions addressed nonclinical study design, data analysis metho
Autor:
Gary Gintant, Devi Kozeli, Matthew Skinner, Syril Pettit, Jennifer B. Pierson, Eunjung Park, James Willard, Todd Wisialowski, Daoqin Bi, Jean-Pierre Valentin, John Koerner
Publikováno v:
British Journal of Pharmacology. 175:606-617
Background and Purpose Translation of nonclinical markers of delayed ventricular repolarization to clinical QTc prolongation (a biomarker for Torsades de Pointes proarrhythmia) remains an issue in drug discovery and regulatory evaluations. A retrospe
Autor:
Donglin Guo, Bernard Fermini, David S. Ramirez, Stephen Jenkinson, Asser Bassyouni, Jason Cordes, Todd Wisialowski, Sunny Z. Sun, David M. Potter, Jill Steidl-Nichols
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 89:9-18
Introduction Cardiac sodium channel antagonists have historically been used to treat cardiac arrhythmias by preventing the reentry of the electrical impulse that could occur following myocardial damage. However, clinical studies have highlighted a si