Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Todd W. Mitchell"'
Autor:
Sarah E. Hancock, Berwyck L.J. Poad, Mark D.P. Willcox, Stephen J. Blanksby, Todd W. Mitchell
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1968-1978 (2019)
Secretions from meibomian glands located within the eyelid (commonly known as meibum) are rich in nonpolar lipid classes incorporating very-long (22–30 carbons) and ultra-long (>30 carbons) acyl chains. The complex nature of the meibum lipidome and
Externí odkaz:
https://doaj.org/article/a4796cc143c346df9602efed9061c8ab
Publikováno v:
Nutrients, Vol 14, Iss 12, p 2495 (2022)
(1) Background: Changes in phospholipid (phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine, i.e., PC, PE and PS) composition with age in the mitochondrial and microsomal membranes of the human cerebellum and motor cortex were exami
Externí odkaz:
https://doaj.org/article/05ef5eb257c64936b142cf852607ed29
Autor:
Gabrielle R. Phillips, Sarah E. Hancock, Andrew M. Jenner, Catriona McLean, Kelly A. Newell, Todd W. Mitchell
Publikováno v:
Nutrients, Vol 14, Iss 10, p 2086 (2022)
Huntington’s disease (HD) is a genetic, neurodegenerative illness that onsets in late adulthood as a series of progressive and terminal cognitive, motor, and psychiatric deficits. The disease is caused by a polyQ mutation in the Huntingtin gene (HT
Externí odkaz:
https://doaj.org/article/6d59c3dc86964a5284aa46806574acce
Autor:
Maximus Berger, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R. Schäfer, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Todd W. Mitchell, Barbara J. Meyer, Andrew Thompson, Alison Ruth Yung, Patrick D. McGorry, G. Paul Amminger
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/40f78615095149b8b106023c773e4673
Autor:
Sarah E. Hancock, Ramesh Ailuri, David L. Marshall, SimonH.J. Brown, Jennifer T. Saville, Venkateswara R. Narreddula, Nathan R. Boase, BerwyckL.J. Poad, Adam J. Trevitt, MarkD.P. Willcox, Michael J. Kelso, Todd W. Mitchell, Stephen J. Blanksby
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1510-1518 (2018)
The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are structurally related to the general class of FA esters of hydroxy FAs (FAHFAs), the ultra-l
Externí odkaz:
https://doaj.org/article/75e7c317588d447f82e39acf63c176b5
Autor:
Maximus Berger, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R. Schäfer, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Todd W. Mitchell, Barbara J. Meyer, Andrew Thompson, Alison Ruth Yung, Patrick D. McGorry, G. Paul Amminger
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
BackgroundDeficiencies in membrane polyunsaturated fatty acids (PUFA) such as omega-3 (n-3) fatty acids are thought to contribute to the pathophysiological processes underlying psychotic disorders. Emerging evidence suggests that the levels of PUFA a
Externí odkaz:
https://doaj.org/article/df0c2ce4a5e24a5aa8a784f6408c8c23
Autor:
Michael G. Friedrich, Amanda Skora, Sarah E. Hancock, Todd W. Mitchell, Paul L. Else, Roger J. W. Truscott
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3521 (2021)
The truncation of Tau is thought to be important in promoting aggregation, with this feature characterising the pathology of dementias such as Alzheimer disease. Antibodies to the C-terminal and N-terminal regions of Tau were employed to examine Tau
Externí odkaz:
https://doaj.org/article/afdd761f19554590a1f46cf13b234256
Autor:
Alan T. Maccarone, Jackson Duldig, Todd W. Mitchell, Stephen J. Blanksby, Eva Duchoslav, J. Larry Campbell
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 8, Pp 1668-1677 (2014)
Glycerophospholipids (GPs) that differ in the relative position of the two fatty acyl chains on the glycerol backbone (i.e., sn-positional isomers) can have distinct physicochemical properties. The unambiguous assignment of acyl chain position to an
Externí odkaz:
https://doaj.org/article/14275e7d9796418a8e44001721b246df
Autor:
Magdalene K. Montgomery, Brenna Osborne, Simon H.J. Brown, Lewin Small, Todd W. Mitchell, Gregory J. Cooney, Nigel Turner
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 12, Pp 3322-3333 (2013)
Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes. Whereas LCFAs promote lipid accumulation and insulin resistance, diets rich in medium-chain fatty acids (MCFAs) have been associated w
Externí odkaz:
https://doaj.org/article/c71ce22b12e344e59963ff23e7207160
Publikováno v:
Biomolecules, Vol 8, Iss 4, p 156 (2018)
In humans, the age of fibre cells differs across the ocular lens, ranging from those formed before birth in the core of the lens to those formed just prior to death in the outer cortex. The distribution of glycerophospholipids in the adult human lens
Externí odkaz:
https://doaj.org/article/aab2b0969bcd4afe978930951c57fccc