Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Todd Vannelli"'
Autor:
Parth Patwari, Todd Vannelli, Lei Cai, Francesco S. Loffredo, James R. Pancoast, Jesse Z. Dong, Richard T. Lee
Publikováno v:
Arthritis & Rheumatology. 66:1247-1255
Objective Acute articular injuries lead to an increased risk of progressive joint damage and osteoarthritis (OA), and no therapies are currently available to repair or protect the injured joint tissue. Intraarticular delivery of therapeutic proteins
Autor:
Frank K. Lee, Gerd Ritter, Todd Vannelli, Chung-Jr Huang, Carl A. Batt, Lloyd J. Old, Rishard H. Chen, Erika Ritter
Publikováno v:
Protein Expression and Purification. 56:212-219
SSX2 is a cancer testis antigen expressed in a wide variety of cancers, including synovial sarcoma and melanoma. It holds promise as a potential antigen for cancer immunotherapy. A process for the production of recombinant SSX2 was developed by overe
Publikováno v:
Metabolic Engineering. 9:142-151
Biological production of p-hydroxycinnamic acid (pHCA) from glucose can be achieved via deamination of the aromatic amino acids l-tyrosine or l-phenylalanine. Deamination of l-phenylalanine produces trans-cinnamic acid (CA) which is further hydroxyla
Autor:
Sabine Breinig, Lixuan Huang, F. Sima Sariaslani, Grace A. Crum, Arie Ben-Bassat, Todd Vannelli, Nancy W. Rizzo, Amee La Bonte Altenbaugh, Robert J Trotman, Sharon L. Haynie
Publikováno v:
Organic Process Research & Development. 11:278-285
An efficient synthesis of 4-vinylphenol (4-VP) from para-hydroxycinnamic acid (pHCA) that uses the enzyme para-hydroxycinnamic acid decarboxylase (PDC) in a two-phase aqueous−organic solvent has been developed. The 4-VP titer and catalyst productiv
Autor:
Gerd Ritter, Todd Vannelli, Michael L. Shuler, Carl A. Batt, Leonardo M. Damasceno, Itzcoatl A. Pla
Publikováno v:
Biotechnology Progress. 22:881-888
Extracellular secretion of over 4 g x L(-1) of the A33 scFv antibody fragment was achieved in Pichia pastoris at the 10 L bioreactor scale using minimal medium and feedback control of the methanol concentration. Since methanol acts as both inducer an
Publikováno v:
Biochemistry. 43:11403-11416
The first three-dimensional structure of phenylalanine ammonia lyase (PAL) has been determined at 2.1 A resolution for PAL from Rhodosporidium toruloides. The enzyme is structurally similar to the mechanistically related histidine ammonia lyase (HAL)
Publikováno v:
Proceedings of the National Academy of Sciences. 96:4615-4620
Methylobacterium sp. strain CM4, an aerobic methylotrophic α-proteobacterium, is able to grow with chloromethane as a carbon and energy source. Mutants of this strain that still grew with methanol, methylamine, or formate, but were unable to grow wi
Publikováno v:
Applied and Environmental Microbiology. 64:1933-1936
Methylobacterium sp. strain CM4 metabolized chloromethane quantitatively with a molar yield of 2.8 g of whole-cell protein/mol of C. This value was similar to that observed after growth with methanol (2.9 g of protein/mol of C) and about three times
Publikováno v:
Antonie van Leeuwenhoek. 71:59-67
The enzymes which catalyze the oxidation of ammonia to nitrite by autotrophic bacteria are reviewed. A comparison is made with enzymes which catalyze the same reactions in methylotrophs and organotrophic heterotrophic bacteria.
Autor:
Todd Vannelli, Alan B. Hooper
Publikováno v:
Biochemistry. 34:11743-11749
The migration of deuterium and hydrogen was observed in the aromatic hydroxylation of specifically deuterated, monosubstituted benzenes catalyzed by ammonia monooxygenase of Nitrosomonas europaea. The phenolic products of the hydroxylation of aromati