Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Todd V. Kuna"'
Publikováno v:
Blood. 110:1982-1988
Several cytoplasmic proteins, such as GTPases of the Ras family, containing a C-terminal CAAX motif are prenylated by farnesyltransferase to facilitate localization to cellular membranes where activation occurs. Farnesyltransferase inhibitors (FTIs)
Publikováno v:
Cancer immunology, immunotherapy : CII. 55(10)
Although melanoma tumors usually express antigens that can be recognized by T cells, immune-mediated tumor rejection is rare. In many cases this is despite the presence of high frequencies of circulating tumor antigen-specific T cells, suggesting tha