Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Todd Tochimoto"'
Autor:
Katjuša Brejc, Jeffrey T. Finer, Maria Pokrovskii, David R. Cox, Daniel W. Pierce, Marc Garard, Ramesh Baliga, Congrong Niu, Todd Tochimoto, Kathleen A. Elias, Guillermo Godinez, Stephen F. Vatner, You Tang Shen, Roman Sakowicz, Bradley P. Morgan, Sandra H. Sueoka, Pu Ping Lu, Fady I. Malik, Tatsuo Katori, Alexander Muci, David Lenzi, David J. Morgans, Corey Valdez, Sheila Sylvester, Kenneth Lee, Xiangping Qian, Ion Suehiro, Erica Kraynack, Raja Kawas, David A. Kass, James J. Hartman, Hector P. Rodriguez, Robert L. Anderson, Wenyue Wang
Publikováno v:
Science. 331:1439-1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling cascades but are limited by their mechanism-related adverse effects. To avoid these limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b655534b7d4dbf40b4a85dea7dd873d
https://doi.org/10.1126/science.1200113
https://doi.org/10.1126/science.1200113
Autor:
Todd Tochimoto, Zhengping Wang, Erica Kraynack, Xiangping Qian, Sheila Sylvester, Ion Suehiro, Alexander Muci, Hong Jiang, S. Corey Valdez, Adam Lewis Tomasi, Smith Whitney W, Kenneth Lee, Robert F. Anderson, Marc Garard, James J. Hartman, Donghong Xu, Hector M. Rodriguez, Guillermo Godinez, Sandra H. Sueoka, Pu-Ping Lu, Scott Collibee, Fady I. Malik, Wenyue Wang, Raja Kawas, Bradley P. Morgan, Nebojsa Djordjevic, Kathleen A. Elias, David J. Morgans
Publikováno v:
ACS Medicinal Chemistry Letters. 1:472-477
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fa6e36712323135868eb9a2d577637
https://doi.org/10.1021/ml100138q
https://doi.org/10.1021/ml100138q